Isolation and Characterization of Cytotoxic and Antibacterial Tetrasaccharide Glyclosides from Ipomoea stans

Reynolds, William F.; Yu, Margaret K.; Enríquez, Raúl G.; Gonzalez, Hilda; Leon, Ismael; Magos, Gil A.; Villareal, María Luisa

doi:10.1021/np50125a014

Cited by 23 publications

(17 citation statements)

References 2 publications

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“…Our results show that aqueous leaf extracts are strong inhibitors of all species of bacteria used in this study with predicted MICs of 1-10 s of μg/mL against E. coli and S. typhimurium and 100-1000 s of μg/mL against S. aureus and S. lactis . There are a few other investigations of other morning glory species in the literature showing antibacterial properties of I. batatas [36], I. murucoides [37] and I. stans [38]. In addition, there are studies demonstrating antifungal properties of undescribed Ipomoea species [39], antinociceptive properties of I. pes-caprae [40] and I. cairica [41], anti-inflammatory and anti-spasmodic activity of I. imperati [42], central nervous system depressant activity of I. stans [43] as well as cytotoxic activity [38], and antimycobacterial and cytotoxic activity of I. tyrianthina [44,45].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of traditional medicinal plants used by Haudenosaunee peoples of New York State

Frey

Meyers

2010

BMC Complement Altern Med

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BackgroundThe evolution and spread of antibiotic resistance, as well as the evolution of new strains of disease causing agents, is of great concern to the global health community. Our ability to effectively treat disease is dependent on the development of new pharmaceuticals, and one potential source of novel drugs is traditional medicine. This study explores the antibacterial properties of plants used in Haudenosaunee traditional medicine. We tested the hypothesis that extracts from Haudenosaunee medicinal plants used to treat symptoms often caused by bacterial infection would show antibacterial properties in laboratory assays, and that these extracts would be more effective against moderately virulent bacteria than less virulent bacteria.MethodsAfter identification and harvesting, a total of 57 different aqueous extractions were made from 15 plant species. Nine plant species were used in Haudenosaunee medicines and six plant species, of which three are native to the region and three are introduced, were not used in traditional medicine. Antibacterial activity against mostly avirulent (Escherichia coli, Streptococcus lactis) and moderately virulent (Salmonella typhimurium, Staphylococcus aureus) microbes was inferred through replicate disc diffusion assays; and observed and statistically predicted MIC values were determined through replicate serial dilution assays.ResultsAlthough there was not complete concordance between the traditional use of Haudenosaunee medicinal plants and antibacterial activity, our data support the hypothesis that the selection and use of these plants to treat disease was not random. In particular, four plant species exhibited antimicrobial properties as expected (Achillea millefolium, Ipomoea pandurata, Hieracium pilosella, and Solidago canadensis), with particularly strong effectiveness against S. typhimurium. In addition, extractions from two of the introduced species (Hesperis matronalis and Rosa multiflora) were effective against this pathogen.ConclusionsOur data suggest that further screening of plants used in traditional Haudenosaunee medicine is warranted, and we put forward several species for further investigation of activity against S. typhimurium (A. millefolium, H. matronalis, I. pandurata, H. pilosella, R. multiflora, S. canadensis).

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Section: Discussionmentioning

confidence: 99%

Antibacterial activity of traditional medicinal plants used by Haudenosaunee peoples of New York State

Frey

Meyers

2010

BMC Complement Altern Med

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“…Ipomoea has been shown to exhibit antibacterial activity (Reynolds et al 1995), and Kaempferia exhibits parasiticidal and tumoricidal activity (Kiuchi et al 1988;Kosuge et al 1985). Other extracts such as those obtained from Terminalia catappa, which have been shown Fig.…”

Section: Discussionmentioning

confidence: 99%

Amebicidal activity of plant extracts from Southeast Asia on Acanthamoeba spp.

Chu

Miles

Toney

et al. 1998

Parasitology Research

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The effect of 100 polar and 100 nonpolar plant extract materials obtained from Southeast Asia were evaluated for amebicidal activity in vitro against three species of Acanthamoeba. A. culbertsoni, A. castellanii, and A. polyphaga, the causative agents of granulomatous amebic encephalitis and amebic keratitis, were studied in vitro to determine whether the plant extracts exhibited amebicidal activity or induced encystment of the amebae. Of the 200 plant extracts tested, extracts obtained from three plants (Ipomoea sp., Kaempferia galanga, and Cananga odorata) were amebicidal for all three species of Acanthamoeba and a fourth extract prepared from Gastrochilus panduratum was lytic for A. polyphaga and growth-inhibitory for A. castellanii and A. culbertsoni. Three plant extracts induced encystment of all three species of Acanthamoeba. Select plant extracts were tested as well for tumoricidal activity against B103 neuroblastoma cells. Some plant extracts that exhibited tumoricidal activity for B103 cells were not amebicidal for Acanthamoeba spp. Additionally, the polar and nonpolar extracts that exhibited amebicidal activity were also tested for activity against primary murine peritoneal macrophage cultures. Plant extracts that demonstrated tumoricidal or amebicidal activity were not lytic for normal macrophage cultures.

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“…From a fraction of I. stans, with pronounced cytotoxicity towards three human tumor cell lines and with specific antibiotic activity against two bacterial strains, were isolated and identified three glycoresins fraction (Reynolds et al, 1995). In other study, were isolated from the roots of I. stans the glycoresins called stansins 1-5.…”

Section: Ipomoea Stans Cavmentioning

confidence: 99%

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

Meira¹,

Silva²,

David³

et al. 2012

Rev. bras. farmacogn.

170

120

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Approximately 600-700 species of Ipomoea, Convolvulaceae, are found throughout tropical and subtropical regions of the world. Several of those species have been used as ornamental plants, food, medicines or in religious ritual. The present work reviews the traditional uses, chemistry and biological activities of Ipomoea species and illustrates the potential of the genus as a source of therapeutic agents. These species are used in different parts of the world for the treatment of several diseases, such as, diabetes, hypertension, dysentery, constipation, fatigue, arthritis, rheumatism, hydrocephaly, meningitis, kidney ailments and infl ammations. Some of these species showed antimicrobial, analgesic, spasmolitic, spasmogenic, hypoglycemic, hypotensive, anticoagulant, anti-infl ammatory, psychotomimetic and anticancer activities. Alkaloids, phenolics compounds and glycolipids are the most common biologically active constituents from these plant extracts.

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Isolation and Characterization of Cytotoxic and Antibacterial Tetrasaccharide Glyclosides from Ipomoea stans

Cited by 23 publications

References 2 publications

Antibacterial activity of traditional medicinal plants used by Haudenosaunee peoples of New York State

Antibacterial activity of traditional medicinal plants used by Haudenosaunee peoples of New York State

Amebicidal activity of plant extracts from Southeast Asia on Acanthamoeba spp.

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

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