Isolation and Characterization of Phytoconstituents from the Stems of &lt;I&gt;Ichnocarpus frutescens&lt;/I&gt;

Aggarwal, Babita; Ali, Mohd; Singh, Vijender; Singla, Rajeev K.

doi:10.3724/sp.j.1009.2010.00401

Cited by 10 publications

(1 citation statement)

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“…)-α-amyrin, 6, 8, 8-trimethylpentacosan-7-one [6], α-amyrin and its acetates, lupeol and its acetates, friedelin, epi-friedelinol and β-sitosterol [7], n-butyl oleate, n-octyl tetracontane, tetratriacontadiene, n-nonadecanyl benzoate, benzocosanyl arachidate [8] .…”

Section: Stem Contains α-L-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→3mentioning

confidence: 99%

Ichnocarpus Frutescens: A Medicinal Plant with Broad Spectrum

Chaudhary¹,

Aggarwal²,

Singla³

2012

IGJPS

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Ichnocarpus frutescens (Black Sariva), an indigenous plant belongs to family Apocyanaceae. According to ayurveda, the plant is having a broad spectrum of use as in atrophy, bleeding gums, convulsions, cough, delirium, dysentery, glossitis, heamaturia, measles etc.Literature data reveals the presence of phenylpropanoids, phenolic acids, coumarines, flavanoids, sterols and pentacyclic triterpenoids and found to have anti-inflammatory, analgesic, antidiabetic, antioxidant and antitumor spectrum of activity. This review article tried to critically cover all the necessary aspects related of Ichnocarpus frutescens.© 2011 IGJPS. All rights reserved.

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Section: Stem Contains α-L-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→3mentioning

confidence: 99%

Ichnocarpus Frutescens: A Medicinal Plant with Broad Spectrum

Chaudhary¹,

Aggarwal²,

Singla³

2012

IGJPS

Self Cite

View full text Add to dashboard Cite

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Triterpenic and monoterpenic esters from stems of Ichnocarpus frutescens and their drug likeness potential

et al. 2014

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Phytochemical studies of ethanolic extract of stems of Ichnocarpus frutescens resulted in the isolation of tetracyclic triterpenic ester lanosteryl oleate (6), two new monoterpenic esters, menth-1(7)-en-9-olyl dodecanoate (7), and 2-(4-methylcyclohex-3-enyl)propyl dodecanoate (8). Their structures were established on the basis of extensive spectral data analysis and chemical methods. From the literature survey, it was revealed that none of these three compounds have been reported earlier from any other parts of I. fructescens. Using StarDrop, drug metabolism and pharmacokinetic parameters have been studied, while data of toxicological endpoints were generated usingDerek Nexus. 7 is metabolically stable as compared to 6 and 8. All three molecules are highly lipophilic so tendency to get distributed in brain and adipose tissue is more. Based on the current knowledge database, Derek Nexus predicted that these molecules are not mutagenic, carcinogenic, genotoxic, hepatotoxic, hERG channel inhibitor, nephrotoxic, neurotoxic but StarDrop found them as probable developmental toxic. So in a word, these phytoconstituents have drug-likeness potential and can be evaluated for possible targets.

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