Isolation and Characterization of α –Amyrin from Stem Bark of Ficus exasperata (Vahl)

Nnamonu, Lami A.; Tor-Anyiin, T. A.; Ugbenyo, N.O.; Anyam, J.V.

doi:10.9734/bji/2016/29737

Cited by 9 publications

(7 citation statements)

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“…Phytochemical investigation of extracts from the genus Ficus revealed the presence of several bioactive secondary metabolites including flavonoids, alkaloids, phenolic acids, steroids, saponins, tannins, terpenoids and coumarins [8][9][10][11][12][13]. In 2016, Nnamonu et al [14] reported the isolation of α-amyrin from the ethyl acetate fraction of the stem bark extract of Ficus exasperata harvested in North Central Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Bergapten from the Root Bark of Ficus exasperata (Vahl)

Famobuwa¹,

Agbowuro

Adekunbi³

et al. 2019

IJBcRR

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Despite the wide ethnomedicinal applications of Ficus exasperata, little is known about the active principles responsible for the observed biological effects, thus limiting opportunities for further therapeutic applications. The bioassay guided chemical investigation of F. exasperata root bark resulted in the isolation of a furocoumarin (D-1) shown to be partly responsible for the acclaimed anti-diabetic effect of the plant.

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Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Bergapten from the Root Bark of Ficus exasperata (Vahl)

Famobuwa¹,

Agbowuro

Adekunbi³

et al. 2019

IJBcRR

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“…The chemical investigation of the leaves extracts of Euclinia longiflora Salisb. by usual chromatographic techniques led to the isolation of two new compounds 1 and 2 together with known compounds including one geddic acid (3), 8 (2S)-1-O-hentriacontanoyl glycerol (4), 9 α-amyrin (5), 10 α-amyrin acetate (6), ursolic acid (7), 11 β-amyrin (8), β-amyrin acetate (9), β-amyrin palmitate (10), 12 oleanic acid (11), maslinic acid (12), 13 betulinic acid (13), 14 cylicodiscic acid ( 14), 15 β-sitosterol (15) stigmasterol ( 17), 16 and their glucosylated derivatives β-sitosterol-3-O-β-glucopyranoside (16) and stigmasterol-3-O-β-glucopyranoside (18)) 17 (Figure 1). The structures of all these isolated compounds were determined based on 1D and 2D nuclear magnetic resonance (NMR) analysis and complemented by electronic impact (EI) and fast atom bombardment (FAB) mass spectrometry (MS) results as well as comparison with data of related compounds described in the literature.…”

Section: Resultsmentioning

confidence: 99%

First report of isolation of antibacterial ceramides from the leaves of Euclinia longiflora Salisb

Munvera

Nyemb

Tamfu

et al. 2021

Natural Product Communications

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Two phytosphingosine-type ceramides (euclinide A (1) and B (2)) were isolated alongside one fatty acid (geddic acid (3)), one fatty acid-1-glyceride ((2 S)-1- O-hentriacontanoyl glycerol (4)), ten triterpenes ( α-amyrin (5), α-amyrin acetate (6), ursolic acid (7), β-amyrin (8), β-amyrin acetate (9), β-amyrin palmitate (10), oleanic acid (11), maslinic acid (12), betulinic acid (13) and cylicodiscic acid (14)) and four sterols ( β -sitosterol (15), stigmasterol (17), and their glucosylated derivatives β-sitosterol-3-O- β-glucopyranoside (16) and stigmasterol-3-O- β-glucopyranoside (18)) from the methanol extract of the leaves of Euclinia longiflora Salisb. using routine chromatographic methods. The structures of the new ceramides and known compounds were determined by analyses of HR-FAB-MS, 1D and 2D NMR (HSQC, HMBC, and NOESY) data and confirmed, where applicable, by comparison with data reported in literature. The methanolic extract and the ceramides were evaluated for their antibacterial activities against different bacterial strains using microdilution method and the MIC values ranged from 6.25 to 50 μg/mL and were considered as moderate activity compared to ciprofloxacin. It is the first report of ceramides in Euclinia longiflora.

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“…A molecular docking study found alpha amyrin to be weakly docking with human estrogen receptors β (ERβ) and hence unlikely to bind to the human estrogen receptor and exhibit selective estrogen receptor modulation. Recent evidence indicated that α-amyrin probably displays its effects through interaction with the cannabinoid pathway while in another study it indicated evidence of participation in protein kinase C and protein kinase A pathways [49]. αamyrin acetate was isolated from other families of plants based on its important biological activities [42,50,51].…”

Section: Table 2 Nmr Spectroscopic Data Of Compound a (C 1 ) Of Solvmentioning

confidence: 99%

Isolation and Characterisation of an Αlpha-amyrin Acetate Isolated from the Leaves of Microtrichia perotitii DC (Asteraceae)

Abdullahi

Ilyas

Hajara

et al. 2018

CSIJ

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Aims: Microtrichia perotitii DC belongs to the family Asteraceae and is widely distributed in West African countries of Nigeria, Senegal, Mali, Port of Guinea, Sieraleone, Ivory Coast, Ghana and Dahomey. In Nigeria it is found in northern part of the country where it is known as Maijankai or Sawun keke in Hausa, Osete in Igbira and Shaware pepe in Yoruba languages. The herb is locally used for treating pain related diseases which includes toothaches, cuts and burns, rashes in children, skin diseases, rheumatism, diarrhea and jaundice. It is on the basis of its significance in trado-medicinal usage that an attempt was being made to isolate the active compounds in the herb. Previous phytochemical screening of the leaves of the herb has confirmed the presence of carbohydrates, tannins, cardiac glycosides, triterpenes, proteins, flavonoids, alkaloids, and steroids. Methods: The leaves of the herb were extracted in methanol in a soxhlet apparatus. The crude CSIJ, 21(3): 1-8, 2017; Article no.CSIJ.39721 2 extract obtained that is Microtrichia perotitii methanol extract (MPME) was fractionated in methanol, ether, aqueous, and n-butanol. Each of these soluble fractions was tested for analgesic and antiinflammatory activities against laboratory animals (mice and rats). The most active fraction was nbutanol which was obtained as a white milky solid A(C 1 ) and its melting point range was 224 -226°C. The compound after re-crystallisation` was subjected to spectroscopic analyses with Infrared, proton and carbon-13 Nuclear Magnetic Resonance spectroscopy. Results: The data obtained for the compound when compared with literature value was found to be an alpha-amyrin acetate. Conclusion: An alpha-amyrin acetate was isolated from the leaf of Microtrichia perotitii for the very first time. Alpha-amyrin acetate has been reported to have broad spectrum of biological activities against some diseases and ailments and could therefore be the leading principle behind many of the ethnomedicinal applications of Microtrichia perotitii. Original Research Article

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Isolation and Characterization of α –Amyrin from Stem Bark of Ficus exasperata (Vahl)

Cited by 9 publications

References 0 publications

Isolation and Characterization of Bergapten from the Root Bark of Ficus exasperata (Vahl)

Isolation and Characterization of Bergapten from the Root Bark of Ficus exasperata (Vahl)

First report of isolation of antibacterial ceramides from the leaves of Euclinia longiflora Salisb

Isolation and Characterisation of an Αlpha-amyrin Acetate Isolated from the Leaves of Microtrichia perotitii DC (Asteraceae)

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