Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia

Nurbek, Stipan; Murata, Toshihiro; Suganuma, Keisuke; Ishikawa, Yoshinobu; Buyankhishig, Buyanmandakh; Kikuchi, Takashi; Byambajav, Tseesuren; Davaapurev, Bekh-Ochir; Sasaki, Kenroh; Batkhuu, Javzan

doi:10.1007/s11418-020-01429-2

Cited by 16 publications

(9 citation statements)

References 32 publications

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“…These Brachanthemum phenylpropanoid dimers (6-10, Fig. 2), sesamin from Artemisia sieversiana (Asteraceae), and some flavonoids from the above plants showed trypanocidal activity (IC 50 2.4-10.0 μM) [32,34,35]. Naranmandakh and coworkers also demonstrated lanostane triterpenoids, isolated from a fungus Fomitopsis officinalis in the family Polyporaceae [36], as active compounds.…”

Section: Trypanocidal Activitymentioning

confidence: 92%

“…Although the livestock consume withered A. sieversiana after autumn, nomadic people have noted the production of meat and milk Fig. 6 Phenylpropanoid oligomers isolated from Dracocephalum foetidum (32 and 33) and saponins (34)(35)(36)(37) from Oxytropis lanata possess hyaluronidase inhibitory activity with an unpleasant odor and flavor during this period. In an attempt to identify the chemical constituents of this plant, Nurbek and coworkers isolated sesquiterpenoids (44-46, Fig.…”

Section: Chemical Interactions Between Forage Plants and Livestockmentioning

confidence: 99%

“…In an attempt to identify the chemical constituents of this plant, Nurbek and coworkers isolated sesquiterpenoids (44-46, Fig. 8), dimers of sesquiterpenoids, flavonoids, lignans, and quinic acid derivatives [35]. The absolute configuration of compound 44 was established using single-crystal X-ray diffraction, and the isolated sesquiterpenoids from Mongolian A. sieversiana were different from known isomers [35].…”

Section: Chemical Interactions Between Forage Plants and Livestockmentioning

confidence: 99%

“…8), dimers of sesquiterpenoids, flavonoids, lignans, and quinic acid derivatives [35]. The absolute configuration of compound 44 was established using single-crystal X-ray diffraction, and the isolated sesquiterpenoids from Mongolian A. sieversiana were different from known isomers [35]. Although the main constituents of this plant have been identified, the reason(s) as to why the plant has undesirable effects on the meat and milk of livestock after autumn still needs to be established.…”

Section: Chemical Interactions Between Forage Plants and Livestockmentioning

confidence: 99%

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Biological activity evaluations of chemical constituents derived from Mongolian medicinal forage plants and their applications in combating infectious diseases and addressing health problems in humans and livestock

Murata

Batkhuu

2021

J Nat Med

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Mongolian nomadic people possess traditional knowledge of wild plants that grow in their areas of habitation. Many of these are forage plants in nature and are consumed by livestock. However, these plants are known to have medicinal and/or toxic properties. To establish a scientific understanding of the plants, and in turn, offer sound knowledge on their applications and effective use, it is essential to collect data pertaining to the chemical constituents of each plant. Therefore, the first objective of this study was to identify and determine the structural constituents of the forage plants that were available to our research group. Furthermore, in an attempt to demonstrate the biological activities of the isolated chemical compounds, we focused on solving some of the social issues affecting Mongolian communities, including protozoan diseases affecting livestock, vectors of infectious diseases, and the general health of humans and their livestock. The results of the chemical constituents derived from Mongolian medicinal plants and their biological activities that were studied in the recent decade are also described herein. Graphic abstract

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Section: Trypanocidal Activitymentioning

confidence: 92%

Section: Chemical Interactions Between Forage Plants and Livestockmentioning

confidence: 99%

Section: Chemical Interactions Between Forage Plants and Livestockmentioning

confidence: 99%

Section: Chemical Interactions Between Forage Plants and Livestockmentioning

confidence: 99%

See 2 more Smart Citations

Biological activity evaluations of chemical constituents derived from Mongolian medicinal forage plants and their applications in combating infectious diseases and addressing health problems in humans and livestock

Murata

Batkhuu

2021

J Nat Med

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“…In the cytopathic effect (CPE) inhibition assays, both plaque reduction assay and virus yield inhibition assay, the compound showed an IC 50 value of about 0.20 µM. On the other hand, antiprotozoal in vitro activity was studied against T. brucei brucei (IC 50 = 95.5 µM) and P. falciparum (IC 50 = 85.5 µM) and T. congolense (IC 50 = 2.9 µM), by Ortiz et al [ 209 ] and Nurbek et al [ 210 ], respectively.…”

Section: Biological Activitymentioning

confidence: 99%

Stevia Genus: Phytochemistry and Biological Activities Update

et al. 2021

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The Stevia genus (Asteraceae) comprises around 230 species, distributed from the southern United States to the South American Andean region. Stevia rebaudiana, a Paraguayan herb that produces an intensely sweet diterpene glycoside called stevioside, is the most relevant member of this genus. Apart from S. rebaudiana, many other species belonging to the Stevia genus are considered medicinal and have been popularly used to treat different ailments. The members from this genus produce sesquiterpene lactones, diterpenes, longipinanes, and flavonoids as the main types of phytochemicals. Many pharmacological activities have been described for Stevia extracts and isolated compounds, antioxidant, antiparasitic, antiviral, anti-inflammatory, and antiproliferative activities being the most frequently mentioned. This review aims to present an update of the Stevia genus covering ethnobotanical aspects and traditional uses, phytochemistry, and biological activities of the extracts and isolated compounds.

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Artemsieverolactones A—H, Eight Guaiane‐Type Sesquiterpenoid Trimers from Artemisia sieversiana

Dong,

Huang,

et al. 2024

Chin. J. Chem.

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Comprehensive SummaryEight new guaiane‐type sesquiterpenoid trimers, artemsieverolactones A—H, possessing unprecedented scaffolds via biocatalyzed [4+2] Diels−Alder cycloaddition reactions were identified from Artemisia sieversiana. Their structures were determined by comprehensive spectroscopic data, single‐crystal X‐ray diffraction analyses, and ECD calculations. In terms of structure, artemsieverolactones A—H are first examples of sesquiterpenoid trimers from guaiane‐type sesquiterpenoid through four different [4+2] Diels−Alder cycloaddition models. Antihepatic fibrosis assay suggested that five compounds exhibited activity against HSC‐LX2 with IC50 values ranging from 37.8 to 117.1 μmol/L. The most active artemsieverolactone B (2) displayed significant inhibitory activity against HSC‐LX2 with IC50 value of 37.8 μmol/L, which was 3 times more active than the positive drug silybin (IC50, 139.7 μmol/L). Preliminary mechanism study revealed that artemsieverolactone B could inhibit the deposition of human collagen type I (Col I), human hyaluronic acid (HA), and human laminin (HL) with IC50 values of 40.4 μmol/L (Col I), 55.1 μmol/L (HL), 47.3 μmol/L (HA), which was 2 to 3‐fold more potent than silybin.

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Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia

Cited by 16 publications

References 32 publications

Biological activity evaluations of chemical constituents derived from Mongolian medicinal forage plants and their applications in combating infectious diseases and addressing health problems in humans and livestock

Biological activity evaluations of chemical constituents derived from Mongolian medicinal forage plants and their applications in combating infectious diseases and addressing health problems in humans and livestock

Stevia Genus: Phytochemistry and Biological Activities Update

Artemsieverolactones A—H, Eight Guaiane‐Type Sesquiterpenoid Trimers from Artemisia sieversiana

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