Isolation and identification of an antifungal compound from endophytic <i>Streptomyces</i>
 sp. CEN26 active against <i>Alternaria brassicicola</i>

Phuakjaiphaeo, C.; Chang, Chen-An; Ruangwong, On‐Uma; Kunasakdakul, Kaewalin

doi:10.1111/lam.12582

Cited by 16 publications

(5 citation statements)

References 15 publications

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“…Compounds derived from Streptomyces are from different chemical groups including aminoglycosides, peptides, tetracyclines, ansamycins, anthracyclines, polyenes, polyethers, beta-lactams, macrolides and nucleosides (Subramani and Aalbersberg 2012). According to multiple studies, Streptomyces is one of the available sources for the production of effective antimicrobial metabolites (Phuakjaiphaeo et al 2016;Riahi et al 2019). The involvement of Streptomyces in the parasitic life and elimination of pathogenic fungal spores has been confirmed in the literature.…”

Section: Introductionmentioning

confidence: 97%

Antifungal activity and mechanism of action of dichloromethane extract fraction A from Streptomyces libani against Aspergillus fumigatus

Azish

Shams-Ghahfarokhi

Razzaghi-Abyaneh

2021

J of Applied Microbiology

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Aims: This study aimed to investigate the mechanism of antifungal action of Streptomyces libani dichloromethane extract fraction A (DCEFA) against Aspergillus fumigatus and the host cytotoxicity. Methods and Results: DCEFA was purified from S. libani by autobiography and showed strong antifungal activity against A. fumigatus. A combination of electron microscopy, cell permeability assays, total oxidant status (TOS) assay, cell cytotoxicity assay and haemolysis activity was carried out to determine the target site of DCEFA. Exposure of A. fumigatus to DCEFA caused the damage to membranous cellular structures and increased release of cellular materials, potassium ions and TOS production. DCEFA was bound to ergosterol but did not affect fungal cell wall and ergosterol content. DCEFA did not show any obvious haemolytic activity for RBCs and toxicity against HEK-293 cell line. Conclusions: DCEFA may inhibit A. fumigatus growth by targeting fungal cell membrane which results in the leakage of potassium ions and other cellular components, TOS production and final cell death. Significance and Impact of the Study: DCEFA of S. libani could be considered as a potential source of novel antifungals which may be useful for drug development against A. fumigatus as a life-threatening human pathogen.

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Section: Introductionmentioning

confidence: 97%

Antifungal activity and mechanism of action of dichloromethane extract fraction A from Streptomyces libani against Aspergillus fumigatus

Azish

Shams-Ghahfarokhi

Razzaghi-Abyaneh

2021

J of Applied Microbiology

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“…isolate UPMRS4 Pyricularia oryzae Ergotamine, Amicomacin, Fungichromin, Rapamycin, N-Acetyl-D, L-phenylalanine Antifungal activity (Awla et al 2016 ) Streptomyces palmae Ganoderma boninense Actinopyrone A, Anguinomycin A, Leptomycin A Antifungal activity (Sujarit et al 2020 ) Streptomyces griseus Phytophthora capsici 1H-pyrrole-2-carboxylic acid Antifungal activity (Nguyen et al 2015 ) Streptomyces sp. CEN26 Alternaria brassicicola 2,5-Bis (hydroxymethyl) furan monoacetate Antifungal activity (Phuakjaiphaeo et al 2016 ) Streptomyces sp. M4 Alternaria spp., Fusarium spp., Colletotrichum spp.…”

Section: Chemical Interactions Between Bacteria and Fungimentioning

confidence: 99%

Bacterial-fungal interactions under agricultural settings: from physical to chemical interactions

Zhou

Wang

et al. 2022

Stress Biology

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Bacteria and fungi are dominant members of environmental microbiomes. Various bacterial-fungal interactions (BFIs) and their mutual regulation are important factors for ecosystem functioning and health. Such interactions can be highly dynamic, and often require spatiotemporally resolved assessments to understand the interplay which ranges from antagonism to mutualism. Many of these interactions are still poorly understood, especially in terms of the underlying chemical and molecular interplay, which is crucial for inter-kingdom communication and interference. BFIs are highly relevant under agricultural settings; they can be determinative for crop health. Advancing our knowledge related to mechanisms underpinning the interactions between bacteria and fungi will provide an extended basis for biological control of pests and pathogens in agriculture. Moreover, it will facilitate a better understanding of complex microbial community networks that commonly occur in nature. This will allow us to determine factors that are crucial for community assembly under different environmental conditions and pave the way for constructing synthetic communities for various biotechnological applications. Here, we summarize the current advances in the field of BFIs with an emphasis on agriculture.

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“…Understanding this interaction has the potential to inform our knowledge of plant-microbe interactions and their implications for ecosystem function. Among them, Streptomyces is a beneficial endo-microorganism, producing bioactive compounds that protect crops such as wheat, rice, tomato, and strawberry, it has produces a variety of novel bioactive compounds, such as kakadumycin, coronamycin, grisin, and conprimycin (Ezra et al, 2004;Cha et al, 2016;Goudjal et al, 2016;Phuakjaiphaeo et al, 2016;Colombo et al, 2019;Kim et al, 2019a;Xu et al, 2019;Mattei et al, 2022). These secondary metabolites have antibacterial and antifungal properties, enhancing growth and protecting against biotic and abiotic stress, with have antifungal to Fusarium, Alternaria, and Pyricularia and antibacterial to Pseudomonas syringae and in abiotic stress related drought and salinity (Wang et al, 2010;Cha et al, 2016;Passari et al, 2017;Jeon et al, 2019;Kim et al, 2019a;Nozari et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Endophytic Streptomyces population induced by L-glutamic acid enhances plant resilience to abiotic stresses in tomato

Kim

Kwak

2023

Front. Microbiol.

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Endophyte bacteria, which colonize plants including roots, stem, flower, and fruit, it can derive their nutrients from the host, are recognized for their mutualistic relationship with the host plant. They play a critical role in promoting host growth and modulating abiotic stress. Carbon and nitrogen have a significant impact on bacterial population and secondary metabolite production, which are highly specific in various categories such as bacterial growth regulation, anti-compounds production. Application of L-glutamic acid can significantly enhance Streptomyces globisporus population buildup in plants. However, the effectiveness of this population buildup against abiotic stresses such as salinity and drought has not been investigated. Therefore, in this study, we tested the bacteria and their prebiotic activity against salinity and drought stress in tomato plants. Three different amino acids were treated on the tomato plants, and it was observed that L-asparagine and L-proline had a negative effect on plant growth and phenotype, while L-glutamic acid promoted plant growth and increased bacteria population density. The bacteria were found to colonize the rhizosphere and root endosphere, with colonization being promoted by L-glutamic acid. Additionally, Streptomyces was found to have plant growth promotion effects and provided protection against abiotic stresses. Interestingly, L-glutamic acid reduced the damage caused by salinity stress, but not drought stress. These findings suggest that L-glutamic acid plays a role in providing tolerance to salinity stress with the core microbiota, thus the current study demonstrated their prebiotic activity in the agriculture system.

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Isolation and identification of an antifungal compound from endophytic Streptomyces sp. CEN26 active against Alternaria brassicicola

Cited by 16 publications

References 15 publications

Antifungal activity and mechanism of action of dichloromethane extract fraction A from Streptomyces libani against Aspergillus fumigatus

Antifungal activity and mechanism of action of dichloromethane extract fraction A from Streptomyces libani against Aspergillus fumigatus

Bacterial-fungal interactions under agricultural settings: from physical to chemical interactions

Endophytic Streptomyces population induced by L-glutamic acid enhances plant resilience to abiotic stresses in tomato

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