Isolation and identification of anti-inflammatory compounds from ethyl acetate fraction of Ecklonia stolonifera and their anti-inflammatory action

Wei, Ran; Lee, Min-Sup; Lee, Bonggi; Oh, Chul‐Woong; Choi, Chang-Geun; Kim, Hyeung‐Rak

doi:10.1007/s10811-016-0847-y

Cited by 26 publications

(17 citation statements)

References 35 publications

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“…330 The rst total synthesis of dictyoxetane 331,332 and the unnatural enantiomer (À)-erogorgiaene, 333 were reported. Additionally, there were many papers dealing with the biological properties of brown algal lipids, [334][335][336][337] polyphenolics [338][339][340][341][342][343][344][345][346][347][348] and carotenoids. [349][350][351][352][353][354][355][356][357][358][359][360] 6 Red algae…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2018

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Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included.

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Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2018

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“…However, the majority of these works were performed with extracts and/or compounds typical from the genus Ecklonia. Indeed, Wei et al [52] observed that the treatment of LPS-stimulated macrophages with an ethyl acetate fraction obtained from the 95% ethanol extract of Ecklonia stolonifera was capable of suppressing NF-κB transcriptional activation not only by preventing IκBα phosphorylation and degradation but also through the inhibition of its translocation to the nucleus. These findings corroborate those previously described by Lee et al [20], who also reported similar results using a crude ethanol extract of the same species.…”

Section: Effects On the Nf-κb Signaling Pathwaymentioning

confidence: 99%

Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-κB Signaling Pathway

Catarino

Silva

Cruz

et al. 2020

IJMS

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Due to their large spectrum of bioactive properties, much attention has recently been drawn to phlorotannins—i.e., phenolic compounds characteristic from brown macroalgae. This study aimed to evaluate the antioxidant and anti-inflammatory properties of F. vesiculosus phlorotannin extracts and purified fractions. Overall, the crude extract and its ethyl acetate fraction (EtOAc) showed good radical scavenging activity, particularly towards nitric oxide (NO•). Subsequent subfractions of EtOAc (F1 to F9) with different molecular weights were then shown to inhibit lipopolysaccharide-induced NO• production in macrophages, with stronger effects being observed for fractions of lower MWs. Of the three intracellular markers analyzed, inducible NO• synthase showed the highest sensitivity to almost all the phlorotannin-rich samples, followed by interleukin 1β and cyclooxygenase 2, which was only inhibited by F2. Furthermore, this subfraction inhibited the phosphorylation and degradation of inhibitory protein κBα, thus preventing the activation of NF-κB and blocking the inflammatory cascade at the transcriptional level. This sample was characterized by the presence of a major compound with a deprotonated molecular ion at m/z 507 with a fragmentation pattern coherent with that of a phlorotannin derivative. Overall, this work unveiled some of the mechanistic aspects behind the anti-inflammatory capacity of phlorotannins from F. vesiculosus, endorsing its use as a possible natural source of anti-inflammatory compounds.

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“…Marine algae contain abundant nutrients and diverse phytochemicals, such as polysaccharides, phlorotannins, protein hydrolysates, and photosynthetic pigments [ 19 ]. Marine-derived natural compounds exert various biochemical effects, including antioxidant [ 20 , 21 ], anti-viral [ 22 ], anti-inflammatory [ 23 , 24 ], anti-diabetic [ 25 ], and anti-allergic properties [ 26 ]. Therefore, there has been growing interest in marine algae as functional foods and nutraceuticals with potential beneficial health effects as sources of antioxidants to reduce the risk of neurodegenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

Enteromorpha prolifera Extract Improves Memory in Scopolamine-Treated Mice via Downregulating Amyloid-β Expression and Upregulating BDNF/TrkB Pathway

Baek

Kim

et al. 2020

Antioxidants

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Enteromorpha prolifera, a green alga, has long been used in food diets as well as traditional remedies in East Asia. Our preliminary study demonstrated that an ethyl acetate extract of Enteromorpha prolifera (EAEP) exhibited the strongest antioxidant activity compared to ethanol or water extracts. Nonetheless, there has been no report on the effect of EAEP on memory impairment due to oxidative damage. This study investigated whether EAEP could attenuate memory deficits in an oxidative stress-induced mouse model. EAEP was orally administered (50 or 100 mg/kg body weight (b.w.)) to mice and then scopolamine was administered. The oral administration of EAEP at 100 mg/kg b.w. significantly restored memory impairments induced by scopolamine, as evaluated by the Morris water maze test, and the passive avoidance test. Further, EAEP upregulated the protein expression of BDNF, p-CREB, p-TrkB, and p-Akt. Moreover, EAEP downregulated the expression of amyloid-β, tau, and APP. The regulation of cholinergic marker enzyme activities and the protection of neuronal cells from oxidative stress-induced cell death in the brain of mice via the downregulation of amyloid-β and the upregulation of the BDNF/TrkB pathway by EAEP suggest its potential as a pharmaceutical candidate to prevent neurodegenerative diseases.

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Isolation and identification of anti-inflammatory compounds from ethyl acetate fraction of Ecklonia stolonifera and their anti-inflammatory action

Cited by 26 publications

References 35 publications

Marine natural products

Marine natural products

Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-κB Signaling Pathway

Enteromorpha prolifera Extract Improves Memory in Scopolamine-Treated Mice via Downregulating Amyloid-β Expression and Upregulating BDNF/TrkB Pathway

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