Isolation and identification of antifungal polyesters from the marine fungus Hypoxylon oceanicum LL-15G256

Bioactive Polyesters in Marine and Plant Endophytic Fungi

“…These features formed part of the AntiMarin search. Two similar macro cyclic polyesters were found from this search 15G256 and 15G256 -1, described by Schlingmann et al [25]. The literature data suggested that compound 5 was 15G256 and compound 6 was 15G256 -1.…”

“…These features, together with the supposed mass 194 Da, were used in an AntiMarin search. The NMR data for a (+)-6-hydroxymellein [25] matched with the data for Compound 2. Therefore, 2 was also shown to be a known compound.…”

“…These features, together with the supposed mass of 680 Da, were used to initiate a search in AntiMarin. These searches found the polyester 15G256 [25] [25], matched the data for compound 4. Therefore, compound 4 was also identified as known polyester.…”

“…Because the compound had the same UV profile as the recorded for the lasiodiplodins, it was considered highly likely to also contain a 1,2,3,5-tetrasubstituted benzene system. These features were entered into the AntiMarin database, together with the supposed mass of 384 Da Two matches were found with the same structure, a polyester named 15G256V [25]. The literature NMR data for this compound also matched those obtained for compound 1.…”

Menisporopsin B, a New Polyester from the Seed Fungus Menisporopsis theobromae BCC 4162

“…Macrocyclic or linear polyesters consisting of 2,4-dihydroxy-6-(2-hydroxypropyl)benzoic acid and 3-hydroxybutyric acid residues have been reported as metabolites of Hypoxylon oceanicum [5], Penicillium verruculosum [6,7], and Scedosporium apiospermum [8], whereas macrocyclic or linear polyesters containing 3,4-dihydro-6,8-dihydroxy-3-(2-hydroxypropyl)isocoumarin residues are unusual.…”