Isolation and Identification of Cissetin — A Setin‐Like Antibiotic with a Novel cis‐Octalin Ring Fusion.

Trichoderma species are free-living fungi that are highly interactive in root, soil and foliar environments and have been used successfully in field trials to control many crop pathogens. Structural and biological studies of the metabolites isolated from Trichoderma species are reviewed. This review, encompassing all the literature in this field up to the present and in which 269 references are cited, also includes a detailed study of the biological activity of the metabolites, especially the role of these metabolites in biological control mechanisms. Some aspects of the biosynthesis of these metabolites and related compounds are likewise discussed.

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“…Cissetin (129) was 4-8 times more active than 126 and 127 against penicillinresistant Streptococcus pneumoniae (Boros et al 2003).…”

Section: Setin-like Metabolitesmentioning

confidence: 99%

Secondary metabolites from species of the biocontrol agent Trichoderma

et al. 2007

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“…These include trichosetin, 16 equisetin and altersetin, 17 CJ-21 058, 18 CJ-17 572 19 and cissetin. 20 CJ-21 058 is also known to inhibit SecA (IC 50 15 mg ml À1 ), an effector of ATP-dependent translocation of precursor proteins across bacterial cell membranes. 18 Altersetin has been reported to exhibit weak in vivo activity in a murine sepsis model at 25 mg kg À1 by i.p.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin

et al. 2014

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The ever-increasing bacterial resistance to clinical antibiotics is making many drugs ineffective and creating significant treatment gaps. This can be only circumvented by the discovery of antibiotics with new mechanisms of action. We report here the identification of a new tetramic acid, ascosetin, from an Ascomycete using the Staphylococcus aureus fitness test screening method. The structure was elucidated by spectroscopic methods including 2D NMR and HRMS. Relative stereochemistry was determined by ROESY and absolute configuration was deduced by comparative CD spectroscopy. Ascosetin inhibited bacterial growth with 2-16 μg ml(-1) MIC values against Gram-positive strains including methicillin-resistant S. aureus. It also inhibited the growth of Haemophilus influenzae with a MIC value of 8 μg ml(-1). It inhibited DNA, RNA, protein and lipid synthesis with similar IC50 values, suggesting a lack of specificity; however, it produced neither bacterial membrane nor red blood cell lysis. It showed selectivity for bacterial growth inhibition compared with fungal but not mammalian cells. The isolation, structure and biological activity of ascosetin have been detailed here.

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Isolation and Identification of Cissetin — A Setin‐Like Antibiotic with a Novel cis‐Octalin Ring Fusion.

Cited by 2 publications

References 1 publication

Secondary metabolites from species of the biocontrol agent Trichoderma

Secondary metabolites from species of the biocontrol agent Trichoderma

Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin

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