Isolation and Identification of Stimulatory and Inhibitory Cell Growth Factors in Bovine Vitreous

Raymond, Laurence N; Jacobson, Bernard

doi:10.1097/00006982-198200210-00011

Cited by 10 publications

(15 citation statements)

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“…Angiogenesis inhibitory factors in vitreous body or epithelial cells of the retina are also reported (Raymond and Jacobson 1982;Glaser et al 1985). In the course of present experiments, we found that angiogenesis inhibitory activity presented in aqueous humor of normal rabbits and the activity gradually decreased following induction of alloxan-induced diabetes (manuscript in preparation).…”

Section: Discussionsupporting

confidence: 58%

Effect of eye-derived growth factors from rabbit retina on proliferation of endothelial cell from marginal vessels.

Okamoto

Oikawa²,

Toyota³

1989

Tohoku J. Exp. Med.

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Section: Discussionsupporting

confidence: 58%

Effect of eye-derived growth factors from rabbit retina on proliferation of endothelial cell from marginal vessels.

Okamoto

Oikawa²,

Toyota³

1989

Tohoku J. Exp. Med.

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“…The retina and vitreous fluid contain endogenous angiogenic inhibitors [7,8,9,10,11]. PEDF, a serine proteinase inhibitor (serpin), has been identified as a potent angiogenic inhibitor endogenously expressed in the retina [12].…”

mentioning

confidence: 99%

Kallikrein-binding protein inhibits retinal neovascularization and decreases vascular leakage

et al. 2003

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Aims/hypothesis. Kallikrein-binding protein (KBP) is a serine proteinase inhibitor (serpin). It specifically binds to tissue kallikrein and inhibits kallikrein activity. Our study was designed to test its effects on retinal neovascularization and vascular permeability. Angiogenesis in the retina is controlled by a delicate balance between angiogenic stimulators (e.g., vascular endothelial growth factor, VEGF) and angiogenic inhibitors (e.g., pigment epithelium-derived factor, PEDF) [1,2,3]. Under certain pathological conditions such as diabetic retinopathy and retinopathy of prematurity (ROP), the retinal cells increase the production of angiogenic stimulators while decreasing angiogenic inhibitors in response to local hypoxia [4,5]. These changes break the balance in angiogenesis control and consequently, resulting in over-proliferation of capillary endothelial cells and retinal neovascularization which is a common cause of blindness [2,3,6]. The molecular mechanism leading to retinal neovascularization is presently not known. Methods. Endothelial cell proliferation was deter

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“…Both activity and concentration of these factors in tissues or blood would be largely variable under various conditions. Furthermore, recent studies suggested the presence of an angiogenesis-inhibiting factor in bovine vitreous body (Brem et al 1977; Raymond and Jacobson 1982;Jacobson et al 1985 …”

mentioning

confidence: 99%

Angiogenesis factors in ocular tissues of normal rabbits on chorioallantoic membrane assay.

Okamoto

Oikawa

Toyota

et al. 1988

Tohoku J. Exp. Med.

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Isolation and Identification of Stimulatory and Inhibitory Cell Growth Factors in Bovine Vitreous

Cited by 10 publications

References 0 publications

Effect of eye-derived growth factors from rabbit retina on proliferation of endothelial cell from marginal vessels.

Effect of eye-derived growth factors from rabbit retina on proliferation of endothelial cell from marginal vessels.

Kallikrein-binding protein inhibits retinal neovascularization and decreases vascular leakage

Angiogenesis factors in ocular tissues of normal rabbits on chorioallantoic membrane assay.

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