Isolation and Identification of the Principal Fungitoxic Component of Turmeric Essential Oil

Dhingra, O. D.; Jham, Gulab N.; Barcelos, Rosimeire Coura; Mendonca, Fernanda A.; Ghiviriga, Ion

doi:10.1080/10412905.2007.9699312

Cited by 46 publications

(25 citation statements)

References 12 publications

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“…Chemical shifts of the turmerones were in accordance with the reported values (Golding and Pombovillar, 1992; Dhingra et al, 2007). The compounds F2&3-A, F2&3-C and F2&3-E were characterized and identified as curcumin, demethoxycurcumin and bisdemethoxycurcumin, respectively, using 1 H NMR spectral analysis and mass spectrometry (Table 1b).…”

Section: Resultssupporting

confidence: 90%

Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa

Yue

Chan

Hon

et al. 2010

Food and Chemical Toxicology

134

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The rhizome of Curcuma longa (CL) has been commonly used in Asia as a potential candidate for the treatment of different diseases, including inflammatory disorders and cancers. The present study evaluated the anti-proliferative activities of the isolated compounds (3 curcuminoids and 2 turmerones) from CL, using human cancer cell lines HepG2, MCF-7 and MDA-MB-231. The immunomodulatory activities of turmerones (α and aromatic) isolated from CL were also examined using human peripheral blood mononuclear cells (PBMC). Our results showed that the curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) and α-turmerone significantly inhibited proliferation of cancer cells in dose-dependent manner. The IC50 values of these compounds in cancer cells ranged from 11.0–41.8 μg/ml. Alpha-turmerone induced MDA-MB-231 cells to undergo apoptosis, which was confirmed by annexin-V & propidium iodide staining, and DNA fragmentation assay. The caspase cascade was activated as shown by a significant decrease of procaspases-3, -8 and -9 in α-turmerone treated cells. Both α-turmerone and aromatic-turmerone showed stimulatory effects on PBMC proliferation and cytokine production. The anti-proliferative effect of α-turmerone and immunomodulatory activities of ar-turmerone were shown for the first time. The findings revealed the potential use of CL crude extract (containing curcuminoids and volatile oil including turmerones) as chemopreventive agent.

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Section: Resultssupporting

confidence: 90%

Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa

Yue

Chan

Hon

et al. 2010

Food and Chemical Toxicology

134

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“…Previous studies had indicated that fatty acid compounds in nonpolar extracts of plants were responsible for antimicrobial, antioxidant, anti-inflammatory, and antiproliferative activities (Geetha et al, 2013;Selvamangai and Bhaskar, 2012). Many scientists have proved that essential oils of turmeric are responsible for antimicrobial activities (Dhingra et al, 2007;Garcia et al, 2008;Pawar and Thaker, 2007).…”

Section: Discussionmentioning

confidence: 99%

Chloroform extract of turmeric inhibits biofilm formation, EPS production and motility in antibiotic resistant bacteria

Hayat

Sabri

McHugh

2017

J. Gen. Appl. Microbiol.

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“…1,8-Cineol, α-terpinolene, β-caryophyllene, and ar-curcumene were the predominant constituents in most cases. ar-Turmerone possessing fungicidal, mosquitocidal, anticonvulsant, and anticancer activities [8,[16][17][18] was found from ripened rhizomes (in September and November). Changes in volatile compounds with development stage were observed.…”

Section: Resultsmentioning

confidence: 99%

“…The extracts of medicinal plants become a great source of antioxidant property [6,7]. It was reported the rhizomes and leaves of C. longa yield essential oils possessing antibacterial, antifungal, anti-inflammatory, antihepatotoxic, antiarthritic, antioxidant and insecticidal activities [2,8,9].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Volatile Compounds of Curcuma longa (Turmeric) and Investigation of the Antioxidant Activity of Rhizome Extracts

Kasai¹,

Ishii²,

Yaoita³

et al. 2017

Med Aromat Plants

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Fragrances originating from plants are widely believed to have therapeutic properties. The volatile compounds originating from Curcuma longa (turmeric) plant cultivated in a medicinal plant garden located in southern Tokyo were investigated using thermal desorption-gas chromatography-mass spectrometry. Sampling from rhizomes of C. longa was performed at three different development stages, i.e., July (when young rhizomes emerge), September (flowers bloom), and November (ready for harvest). Using a polydimethylsiloxane (PDMS)-coated bar as an adsorption device for volatile compounds, 1,8-cineol, α-terpinolene, β-caryophyllene, and ar-curcumene were the predominant constituents in most cases. Additional volatile compounds such as α-terpinene, p-cymene, and (E)-β-farnesene were identified when PDMS/carboxene/divinylbenzene-coated fiber was used. ar-Turmerone was found from ripened rhizomes (in September and November). The leaves of C. longa yielded the same compounds as the rhizomes as well as compound characteristic of leaves such as 3-hexen-1-ol. The volatile compounds obtained from C. longa roots were the same as those from the rhizomes.The antioxidant activity of both water and methanol extracts of C. longa rhizomes collected from the medicinal plant garden was confirmed using electron spin-resonance spin-trapping method with potent scavenging activity against superoxide anion radical (O 2 ˑˉ). Extracts from ripe rhizomes ready for harvest exhibited greater antioxidant activity than those obtained from young rhizomes.

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Isolation and Identification of the Principal Fungitoxic Component of Turmeric Essential Oil

Cited by 46 publications

References 12 publications

Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa

Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa

Chloroform extract of turmeric inhibits biofilm formation, EPS production and motility in antibiotic resistant bacteria

Analysis of Volatile Compounds of Curcuma longa (Turmeric) and Investigation of the Antioxidant Activity of Rhizome Extracts

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