2019
DOI: 10.14233/ajchem.2019.21798
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Isolation and Structural Characterization of Degradation Products of Aceclofenac by HPLC, HRMS and 2D NMR

Abstract: The stability of aceclofenac under stress conditions was assessed to identify the degradation products. So, it was subjected to stress conditions like acid, base and oxidation, according to ICH guideline Q1A (R2). One degradation product formed when the drug was subjected to acid stress. Three degradation products were formed during the basic stress condition. The drug substance was found to be stable to oxidative stress. The degradants formed during the stress were separated on a C-18 column using gradient pr… Show more

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Cited by 1 publication
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“…[7][8] Numerous spectrophotometric approaches are available to the determination of RANO in tablets and bulk medicines. 9,10 Chromatographic analysis of RANO in bulk and tablets, 11 high-performance thin layer chromatography (HPTLC), 12,13 stability-indicating analytical methods, [14][15][16][17][18][19] Enantiomeric separation, 20 identification of RANO and its contaminants related to the process 21 and several quantification approaches were developed for Ranolazine identification and metabolites of ranolazine in biological samples using liquid chromatographymass spectrometry (LC-MS). [22][23][24][25][26] However, until now, the LC-MS method has not been documented for the two RANO probable genotoxic contaminants.…”
Section: Introductionmentioning
confidence: 99%
“…[7][8] Numerous spectrophotometric approaches are available to the determination of RANO in tablets and bulk medicines. 9,10 Chromatographic analysis of RANO in bulk and tablets, 11 high-performance thin layer chromatography (HPTLC), 12,13 stability-indicating analytical methods, [14][15][16][17][18][19] Enantiomeric separation, 20 identification of RANO and its contaminants related to the process 21 and several quantification approaches were developed for Ranolazine identification and metabolites of ranolazine in biological samples using liquid chromatographymass spectrometry (LC-MS). [22][23][24][25][26] However, until now, the LC-MS method has not been documented for the two RANO probable genotoxic contaminants.…”
Section: Introductionmentioning
confidence: 99%