Isolation and Structure of Gustastatin from the Brazilian Nut Tree Gustavia hexapetala^,1

Abstract

A bioassay-guided investigation of Gustavia hexapetala led to the isolation of a new cancer cell growth inhibitor designated gustastatin (1) and four previously known cancer cell growth inhibitors that included betulinic acid (2). The structures were assigned on the basis of analyses of HRMS combined with 1D and 2D NMR data. The structure of portentol (5) was confirmed by an X-ray crystal structure determination.

Bioprospecting of Novel and Bioactive Metabolites from Endophytic Fungi Isolated from Rubber Tree Ficus elastica Leaves

“…Lichexanthone (5) is a well-known metabolite of lichens and is also found in many filamentous fungi species [36,37]. It has been reported to possess antimicrobial and antitumor activity [38][39][40][41]. Compound 5, as a main product, was isolated from strain Fes1712, and its broad-spectrum antibacterial activity was confirmed by bioactivity tests in this study.…”

Qualitative and Spatial Metabolite Profiling of Lichens by a LC–MS Approach Combined With Optimised Extraction

“…1 H‐NMR (CD 3 OD, 300 MHz) and 13 C‐NMR (CD 3 OD, 75 MHz) data are comparable to published data (Huneck and Yoshimura, ; Pettit et al ., ); [ α ] D : +40.3 (c = 1, CH 3 OH); HREIMS: m/z 375.17820 [M + Na] + (calculated for C 19 H 28 O 6 Na: 375.17836).…”

Naturally-Occurring Xanthones: Recent Developments

“…Meanwhile, an increasing number of bioactive xanthones has been isolated by bioassay-guided fractionation methods. Among the biological activities used to monitor the isolation of bioactive xanthones are antibacterial [15], antifungal [16], antiviral [17,18] trypanocidal [19,20] activities and cytotoxicity against human carcinoma cell lines [21][22][23][24]. Some specific activities such as potentiation of nerve growth factor (NGF) action in the PC12D cell [25] and secreted aspartic protease (SAP) of Candida albicans [26] have also been used to monitor the isolation of several bioactive prenylated xanthones.…”