Isolation and Synthesis of Biologically Active Carbazole Alkaloids

Characterization of Merbau Extractives as a Potential Wood-Impregnating Material

“…The flavonoids found in ME were as abundant as the phenolic compounds. The absence of alkaloid, steroid, and saponin secondary metabolites from the stem extract can be explained by their typically limited presence in leaves (Knölker and Reddy 2002). On the other hand, flavonoid and phenolic compounds are abundant in the stems as they (particularly the phenolic compounds) are the precursors for the biosynthesis of primary wood components such as lignin and cellulose (Harborne 1984;Obst 1998;Umezawa 2001).…”

Synthesis and biological evaluation of novel series of aminopyrimidine derivatives as urease inhibitors and antimicrobial agents

“…Like pyrimidines, carbazole compounds also exhibits diverse biological properties. Carbazole and its derivatives are the important class of heterocyclic compounds endowed with various pharmacological activities such as anticancer, antimicrobial, antiviral, anti-inflammatory and antioxidant activity 29 . Carbazole scaffold is present in many drugs such as carvedilol and carprofen ( Figure 1).…”

A new scaffold of topoisomerase I inhibitors: Design, synthesis and biological evaluation

“…The interest in topoisomerase I as a therapeutic target promoted various efforts to identify other chemotypes effective as topoisomerase inhibitors and chemical/modelling efforts to rationally design specific analogs among known inhibitors [8,9,10,11] . During the last years several tetra-and pentacyclic structures containing the indoline fragment has received much attention due to the structural correlation with natural compounds belonging to the alkaloids class endowed with biological activity as cyclooxygenase/5-lipooxygenase inhibitors, characterized by the presence of the pyrrolo[3,2-de]acridine subunit [12] , indolocarbazoles non-CPT topo I inhibitors [13,14,15,16] and analogues of physostigmine alkaloids [17,18,19,20] .…”