Isolation, characterization and DFT studies of epoxy ring containing new withanolides from Withania coagulans Dunal

Khan, Shahid Ali; Adhikari, Achyut; Ayub, Khurshid; Farooq, Aliya; Mahar, Saima; Qureshi, Muhammad Nasimullah; Khan, Sher Bahadar; Ludwig, Ralf; Mahmood, Tariq

doi:10.1016/j.saa.2019.03.046

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…The presence of an α-oriented ether bridge between C-14 and C-20 is the most remarkable feature of 14α,20α-epoxywithanolides. Only two 14α,20α-epoxywithanolides, namely withacoagulin J ( 456 ) 137 and withacogulanoside-B ( 457 ), 138 were found in the coverage period. Both 456 and 457 were isolated from Withania coagulans Dunal, and 457 is a 27- O -glycoside.…”

Section: Phytochemical Investigationsmentioning

confidence: 99%

Natural withanolides, an update

et al. 2022

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Section: Phytochemical Investigationsmentioning

confidence: 99%

Natural withanolides, an update

et al. 2022

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“…Coagulansin B and coagulanolide are also amongst the metabolites of W. coagulans [51,52]. Withacoagulin J was identified as well as isolated along with already known withanolide H [53]. Withanolide named as (20R,22R)-14α,17,20β,27trihydroxy-1-oxowitha-5,24-dienolide-27β-(O-β-D-glucopyranoside was also discovered latterly [53,54].…”

Section: Novel Isolated Compounds Of W Coagulansmentioning

confidence: 85%

“…Withacoagulin J was identified as well as isolated along with already known withanolide H [53]. Withanolide named as (20R,22R)-14α,17,20β,27trihydroxy-1-oxowitha-5,24-dienolide-27β-(O-β-D-glucopyranoside was also discovered latterly [53,54]. Furthermore, withacogulanoside-B along with five known withanolides was isolated [55].…”

Section: Novel Isolated Compounds Of W Coagulansmentioning

confidence: 87%

Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review

et al. 2021

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Herbal plants have been utilized to treat and cure various health-related problems since ancient times. The use of Ayurvedic medicine is very significant because of its least reported side effects and host of advantages. Withania coagulans (Family; Solanaceae), a valuable medicinal plant, has been used to cure abnormal cell growth, wasting disorders, neural as well as physical problems, diabetes mellitus, insomnia, acute and chronic hepatic ailments. This review provides critical insight regarding the phytochemistry, biological activities, and pharmacognostic properties of W. coagulans. It has been known to possess diuretic, anti-inflammatory, anti-bacterial, anti-fungal, cardio-protective, hepato-protective, hypoglycemic, anti-oxidative, and anti-mutagenic properties owing to the existence of withanolides, an active compound present in it. Apart from withanolides, W. coagulans also contains many phytochemicals such as flavonoids, tannins, and β-sterols. Several studies indicate that various parts of W. coagulans and their active constituents have numerous pharmacological and therapeutic properties and thus can be considered as a new drug therapy against multiple diseases.

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