Isolation, characterization of syringin, phenylpropanoid glycoside from Musa paradisiaca tepal extract and evaluation of its antidiabetic effect in streptozotocin-induced diabetic rats

Krishnan, Shanmuga Sundaram Chinna; Subramanian, Iyyam Pillai; Subramanian, S.

doi:10.1016/j.bionut.2013.12.009

Cited by 39 publications

(30 citation statements)

References 27 publications

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“…consider this effect to be dose dependent. In addition, oral administration of syringin, umbelliferone and lupeol also demonstrated hypoglycaemic effects. These results are in accordance with other studies that have evaluated these isolated compounds.…”

Section: Resultsmentioning

confidence: 98%

“…Borah and Das, Dhanabal et al ., Jawla, Kumar, and Khan, Nisha and Mini, Ramu et al ., Sundaram and Subramian, and Sundaram et al . performed in vivo hypoglycaemic evaluation.…”

Section: Resultsmentioning

confidence: 99%

“…For the animal model tests, Wistar rats were separated into different groups: normal control group (nondiabetic rats treated only with the vehicle), diabetic control rats (treated only with vehicle or untreated), diabetic rats (animals that received an antidiabetic drug – positive control) and diabetic animals treated with extract or with isolated compounds of M. paradisiaca (syringin, umbelliferone and lupeol). The dose of extracts administered varied between 100 and 500 mg/kg body weight, and the antidiabetic drugs used in the positive control group were insulin, glibenclamide, gliclazide and metformin . The diabetic state was induced via a single intraperitoneal injection of streptozotocin or alloxan monohydrate .…”

Section: Resultsmentioning

confidence: 99%

“…The diabetic state was induced via a single intraperitoneal injection of streptozotocin or alloxan monohydrate . The animals were considered as diabetic when blood glucose values were above 200 mg/dl or 250 mg/dl …”

Section: Resultsmentioning

confidence: 99%

“…Another complication caused by chronic hyperglycaemia is the acceleration of protein catabolism and excess lipolysis, leading to total protein reduction, increased lipid profile and weight loss . Treatment with the extract and the isolated compounds enhanced total protein and haemoglobin levels . Furthermore, at the end of the studies of Borah and Das and Ramu et al ., the treated diabetic groups exhibited a significant reduction in total blood cholesterol, serum triglycerides and serum low‐density‐lipoprotein, while there were significant increases in serum high‐density‐lipoprotein and body weight.…”

Section: Resultsmentioning

confidence: 99%

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Antidiabetic potential of Musa spp. inflorescence: a systematic review

Vilhena

Fachi

Marson

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives Extracts of parts Musa spp. have been used for the treatment of various diseases in traditional medicine. Studies have shown that these extracts have hypoglycaemic properties. The aim of this work was to gather evidence on the antidiabetic effects of Musa spp. inflorescence. Methods A systematic review was conducted with searches in three electronic databases, along with manual searches. Studies evaluating the antidiabetic properties of extracts of flower or bract of the genus Musa (in vitro or in vivo) were included. Key findings Overall, 16 studies were found. The reported assays were of hypoglycaemic effects, oral glucose tolerance, inhibitory activities in carbohydrate metabolism and digestive enzymes, enhanced glucose uptake activity and popular use of the extract in patients with diabetes type 2. In vitro studies showed that use of the extract was associated with antidiabetic effects (e.g. increased glucose uptake and inhibition of carbohydrate digestion enzymes). In induced diabetic models, Musa spp. extracts showed dose‐dependent glycaemic level reductions compared with pharmacological drugs (P < 0.05). Summary In general, promising results regarding antidiabetic activity were found for inflorescence of Musa spp., suggesting that this plant could represent a natural alternative therapy for treating diabetes mellitus type 2.

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Section: Resultsmentioning

confidence: 98%

“…Borah and Das, Dhanabal et al ., Jawla, Kumar, and Khan, Nisha and Mini, Ramu et al ., Sundaram and Subramian, and Sundaram et al . performed in vivo hypoglycaemic evaluation.…”

Section: Resultsmentioning

confidence: 99%