Isolation, Chemical Transformation, and Antifungal Potential of Sesquiterpene Lactones from Inula Racemosa

Kaur, Ramandeep; Chahal, K. K.; Urvashi, .

doi:10.1007/s10600-020-02989-1

Cited by 14 publications

(9 citation statements)

References 7 publications

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“…The major ketone present in IR is sesquiterpene lactones, such as alantolactone and isoalantolactone. These are the major phytochemicals present in IR roots that are responsible for various pharmacological activities [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells

Yousuf

Shabir²,

Kauts³

et al. 2022

Molecules

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Natural antioxidants derived from plants have played a vital role in preventing a wide range of human chronic conditions and provide novel bioactive leads for investigators in pharmacotherapy discovery. This work was designed to examine the ethnopharmacological role of Urtica dioica (UD), Capsella bursa-pastoris (CBP), and Inula racemosa (IR). The total phenolic and flavonoid contents (TPC and TFC) were illustrated through colorimetric assays, while the antioxidant activity was investigated through DPPH and ABTS assays. The evaluation of phytochemicals by FT-IR of UD and CBP revealed high contents of aliphatic amines, while IR showed a major peak for ketones. The antioxidant activity, TPC and TFC were highest in the ethanol extract of UD, followed by CBP, and IR showed the lowest activity. All of the extracts revealed significant antioxidant capacities along a dosage gradient. Through a HPLC analysis at a wavelength of 280 nm, UD leaves demonstrated an intense peak of quercetin, and the peak for rutin was less intense. CBP (whole plant), instead, demonstrated a major yield of rutin, and a peak for quercetin was not observed in CBP. IR (rhizomes) showed both quercetin and rutin. All of the extracts were significantly cytotoxic to HepG2 cells after 48 h with the trend IR > UD > CBP. The outcomes of this study may be effective in the selection of specific plants as realistic sources of the bioactive components that might be useful in the nutraceutical progression and other biomedical efficacies.

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Section: Discussionmentioning

confidence: 99%

Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells

Yousuf

Shabir²,

Kauts³

et al. 2022

Molecules

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“…Plasmopara viticola, the fungus responsible for downy mildew in grapes, can be inhibited by Ala (Seca et al, 2014). The spore germination of Dreschlera oryzae, Fusarium moniliforme, and Alternaria triticina, the phytopathogenic fungi causing reduced yield and quality in crops, can also be suppressed by Ala (Kaur et al, 2020).…”

Section: Antifungalmentioning

confidence: 99%

Alantolactone: A sesquiterpene lactone with diverse pharmacological effects

et al. 2021

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Alantolactone (Ala) is a sesquiterpene lactone that can be isolated from many herbal plants belonging to Asteraceae. Besides the antimicrobial activities against bacteria, fungi and viruses, Ala has also demonstrated significant antiinflammatory effects in various models by inhibiting NF-κB and MAPKs to decrease the pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α. The antitumor effects of Ala have been demonstrated in vitro and in vivo via inducing intrinsic apoptosis, oxidative stress, ER stress, cell cycle arrest and inhibiting autophagy and STAT3 phosphorylation, which are also involved in its combination or synergy with other antitumor drugs. Ala also has neuroprotective activity through attenuating oxidative stress and inflammation, besides its modulation of glucose and lipid metabolism. This review summarizes the recent advances of the pharmacological effects of Ala, including anti-inflammatory, antitumor, antimicrobial, neuroprotective activities, as well as the underlying mechanisms.Ala might be employed as a potential lead to develop drugs for multiple diseases.

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“…Kaur and co-workers have recently reported a number of semi-synthetic derivatives ( 225 – 228 ) of the natural product and their biological evaluation [ 117 ]. Alantolactone ( 184 ), upon reaction with diazomethane, afforded pyrazoline derivative 228 as a major product ( Scheme 48 ).…”

Section: Biological Activities and Chemistry Of Natural And Synthementioning

confidence: 99%

“…Reagents and conditions: (a) CHBr 3 , 50% aq. KOH, TEBAC, 5 h; (b) NaBH 4 , MeOH, 25 min; (c) Mg, dry MeOH, 3 h; (d) TEA, diazomethane, overnight; (e) CF 3 CO 3 H, Na 2 CO 3 , DCM, 0 °C; (f); (g) Pd(OAc) 2 /(2-MeC 6 H 4 ) 3 , trimethylamine, DMF [ 117 , 119 , 120 ].…”

Section: Figures Schemes and Tablementioning

confidence: 99%

Natural and Synthetic Lactones Possessing Antitumor Activities

Kim

Sengupta

Sim

2021

IJMS

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Cancer is one of the leading causes of death globally, accounting for an estimated 8 million deaths each year. As a result, there have been urgent unmet medical needs to discover novel oncology drugs. Natural and synthetic lactones have a broad spectrum of biological uses including anti-tumor, anti-helminthic, anti-microbial, and anti-inflammatory activities. Particularly, several natural and synthetic lactones have emerged as anti-cancer agents over the past decades. In this review, we address natural and synthetic lactones focusing on their anti-tumor activities and synthetic routes. Moreover, we aim to highlight our journey towards chemical modification and biological evaluation of a resorcylic acid lactone, L-783277 (4). We anticipate that utilization of the natural and synthetic lactones as novel scaffolds would benefit the process of oncology drug discovery campaigns based on natural products.

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Isolation, Chemical Transformation, and Antifungal Potential of Sesquiterpene Lactones from Inula Racemosa

Cited by 14 publications

References 7 publications

Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells

Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells

Alantolactone: A sesquiterpene lactone with diverse pharmacological effects

Natural and Synthetic Lactones Possessing Antitumor Activities

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