Isolation Compound Anti-Obesity from the Bark Ara (Ficus Racemosa) of Aceh

Nasution, Rosnani; Mustanir,; Marianne,; Marzuki, Iswani

doi:10.13005/ojc/320542

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…Terjadinya inflamasi ditandai dengan migrasi sel leukosit dari sirkulasi darah pada bagian peradangan. Oleh karena itu untuk mengetahui aktivitas efek anti-inflamasi dengan mengamati jumlah sel leukosit yang berkurang pada bagian peradangan (Nasution et al, 2016).…”

Section: Pendahuluanunclassified

ANTI INFLAMMATORY ACTIVITY OF SUNGKAI LEAVES (Peronema canescens JACK) ETHANOL EXTRACT IN CARRAGEENAN INDUCED MICE

Latief

Fisesa

Sari

et al. 2021

JFSP

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Anti-inflammatory compounds play a role by inhibiting the formation of prostaglandin mediators, inhibiting the migration of leukocytes to the area of inflammation, and inhibiting the release of prostaglandins from the cells where they are located. Several plant-derived compounds that can act as anti-inflammatory candidates are flavonoids, saponins, alkaloids, and phenols. This study aims to determine the anti-inflammatory activity of the ethanol extract of Sungkai leaves and to determine the effect of the concentration given on the level of anti-inflammatory activity. The method used was the formation of granuloma pockets and edema on the mice's backs by inducing subcutaneous carrageenan using ethanol extract of Sungkai leaves with various concentrations of 5%, 10%, and 15%, respectively. The results of anti-inflammatory activity showed that the ethanol extract of Sungkai leaves had a significant effect on the average exudate volume and the percentage of inflammation inhibition. At a concentration of 15%, the extract was able to reduce the volume of exudate by 46,67 ± 5,506 µl and inhibition of inflammation by 87.78%. In addition, the ethanol extract of Sungkai leaves significantly affected lymphocytes, stem neutrophils, and segment neutrophils, but did not significantly affect the number of monocyte cells. At a concentration of 15%, the ethanol extract of Sungkai leaves showed the smallest number of leukocyte cell types, namely 50.11 ± 2.389 lymphocyte cells; stem neutrophil cells 10,44 ± 0,475; segmented neutrophil cells were 19.78 ± 0.596 and monocyte cells 2,0 ± 0,236. It can be concluded that the ethanol extract of Sungkai leaves has anti-inflammatory activity but has not approached the effect of anti-inflammatory drugs in general.

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Section: Pendahuluanunclassified

ANTI INFLAMMATORY ACTIVITY OF SUNGKAI LEAVES (Peronema canescens JACK) ETHANOL EXTRACT IN CARRAGEENAN INDUCED MICE

Latief

Fisesa

Sari

et al. 2021

JFSP

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“…Semi-solid preparations that are comfortable when used in the skin are formulation preparations that have a spreading power diameter ranging from 5-7 cm or equivalent to 19. 6 . It is assumed that the 16% formulation, which has very low dispersion, can cause discomfort when used on the skin because it causes stickiness.…”

Section: Spreadability Of the Lotionmentioning

confidence: 99%

“…Aceh is a tropical region that is very many overgrown by various plants that have medicinal properties, such as Artocarpus camansi, which is efficacious as an antidiabetic drug [1], [2], [3], [4] and also Ficus racemosa and Morus alba which can lose weight [5], [6]. Mimusops elengi plants were also found, which are very easy to find in various regions of Aceh.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Hand Lotion of Flower Mimusops elengi

Arifin¹,

Nasution²,

Desrianti³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Aceh is a tropical region that is very many overgrown by various plants that have medicinal properties; one of them is M. elengi. M. elengi flower extract has the main content of triterpene and alcohol, that have antibacterial, antifungal, antioxidant and antineoplastic activity. Extraction of chemical compounds containing essential oils generally uses distillation, and get the small amounts of chemical compounds, while the maceration with n-hexane solvent, producing less active nonpolar compounds against S. aureus bacteria. AIM: Isolating the methanol extract from M. elengi flowers and test its antibacterial and antifungal activity. Furthermore, extracts with active concentrations are made into a lotion. METHODS: Methanol extract from M. elengi flower was characterised by gas chromatography-mass spectrometry, then tested for antibacterial and antifungal, then made into the lotion. The lotion was tested again for its antimicrobial activity, physical and organoleptic properties. RESULTS: The most abundant chemical compounds in an extract of M. elengi based on characterisation with GC-MS is Borneol L; (Bicyclo [2.2.1] heptane-2-ol, 1,7,7-trimethyl, as much as 82%). The methanol extract of M. elengi flower can inhibit the growth of S. aureus bacteria and C. albicans fungi, and also the lotion from methanol extract can inhibit the growth of S. aureus bacteria, but the M. elengi flower extract lotion cannot inhibit the growth of C. albicans fungi. The lotion inhibits the growth of S. aureus bacteria, from a concentration of methanol extract of 8% and 16%. Lotion with 16% methanol extract has 81.33% in activity power compared with positive control. The results of physical and organoleptic properties test, with the concentration of methanol extract of M. elengi 1, 2, 8, and 16%, have pH in the range of 6.6-8 (still in a safe range, 4.5-9 according to SNI 16-4399-1997). The lotion type is m/a, the spreading capacity of the lotion is 18.8 - 39.5 cm2. The power of adhesive at skin ranges from 1 minute 27 seconds to 3 minutes 7 seconds. The viscosity of the lotion ranges from 23,670-24,400 cP, this range is in the range based on SNI 16-4399-1996 (2000-50,000 cP), so the lotion is in a good category. The preferred lotion is at a concentration of 2%, in fragrance. CONCLUSION: Antibacterial activity of the lotion of methanol extract of M. elengi flower against S. aureus bacteria was the best at 16%, but could not inhibit the growth of C. albicans fungi. The most abundant compounds in methanol extract are Borneol L compounds; (Bicyclo [2.2.1] heptane-2-ol, 1,7,7-trimethyl. In general, the physical properties of this lotion meet the requirements of SNI16-4399-1996, SNI 16-4399-1997, and lotions which are preferred at a concentration of 2% in fragrance.

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“…Aceh is a tropical region in Indonesia overgrown by various medicinal plants, like Artocarpus camansi [1-3], Ficus racemosa, Morus alba [4][5], and Azadirachta indica A. Juss. A. indica A. Juss or Meliaceae, known as Neem trees, originally came from India, Bangladesh, Thailand, Nepal, and Pakistan.…”

Section: ■ Introductionmentioning

confidence: 99%

Isolation of Ethyl p-Methoxycinnamate from Azadirachta indica Root Bark as Hong Kong Caterpillar (Tenebrio molitor) Antifeedant

et al. 2021

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This study aims to identify the antifeedant activity of Azadirachta indica A. Juss root bark against Hong Kong caterpillar (Tenebrio molitor). A. indica A. root was macerated in n-hexane, ethyl acetate, and methanol. The investigation of antifeedant activity was conducted by using the no choice leaf disk method. The antifeedant activity (%AI) tests showed that the extracts of n-hexane, ethyl acetate, and methanol with each concentration of 0.5% were 6.71, 71.78, and 40.14%, respectively. The ethyl acetate extract demonstrated the most active antifeedant activity. Ethyl acetate extract was fractionated to obtain five subfractions (A-E). Each subfraction with each concentration of 0.5% showed the %AI of 70.55, 85.29; 67.40, 82.70 and 82.22%, respectively. Furthermore, GC-MS results demonstrated that ethyl acetate extract contained 19 compounds. The main compounds are methyl hexadecanoate and methyl 8-octadecenoate. Further purification of fraction A, which has the highest amount, was then carried out. The obtained isolate, i.e., A32, was determined as ethyl p-methoxycinnamate confirmed by 13C- and 1H-NMR, FTIR, and MS spectra. The presence of ethyl p-methoxycinnamate makes A. indica A. root is potential as T. molitor antifeedant. The implication of these findings is to reference herbal antifeedants and reduce the use of synthetic pesticides.

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Isolation Compound Anti-Obesity from the Bark Ara (Ficus Racemosa) of Aceh

Abstract: The extract n-hexane and ethyl acetate obtained from plants Ficus racemosa, respectively of 68.50 g (2.28%) and 50

Cited by 7 publications

References 2 publications

ANTI INFLAMMATORY ACTIVITY OF SUNGKAI LEAVES (Peronema canescens JACK) ETHANOL EXTRACT IN CARRAGEENAN INDUCED MICE

ANTI INFLAMMATORY ACTIVITY OF SUNGKAI LEAVES (Peronema canescens JACK) ETHANOL EXTRACT IN CARRAGEENAN INDUCED MICE

Antimicrobial Activity of Hand Lotion of Flower Mimusops elengi

Isolation of Ethyl <i>p</i>-Methoxycinnamate from <i>Azadirachta indica</i> Root Bark as Hong Kong Caterpillar (<i>Tenebrio molitor</i>) Antifeedant

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