Isolation, identification and characterization of a novel antioxidant protein from the nematocyst of the jellyfish Stomolophus meleagris

Li, Rongfeng; Yu, Huan; Xing, Ronge; Liu, Song; Qing, Yukun; Li, Kecheng; Li, Bing; Meng, Xiangtao; Cui, Jinhui; Li, Pengcheng

doi:10.1016/j.ijbiomac.2012.05.015

Cited by 33 publications

(27 citation statements)

References 25 publications

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“…The NA has been incorporated into topical ointments targeted for a wide range of dermatological disorders [22,23,24]. Although there are concerns regarding the worldwide increase of the gelatinous biomass of jellyfish, an increasing number of results also showed that the jellyfish could be used as a new source of marine drugs [25,26]. In this regard, we isolated a peptide, isoleucine–valine–histidine (IVH), from a jellyfish and synthesized a novel molecule, NA–IVH, by conjugating NA to IVH, in orer to enhance the cellular-protective effects of NA.…”

Section: Introductionmentioning

confidence: 99%

A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells

et al. 2018

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Nicotinamide (NA), a water-soluble vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl–isoleucine–valine–histidine (NA–IVH), by combining NA with jellyfish peptides’ IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA–IVH. We found that NA–IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA–IVH protected the cells from hydrogen peroxide (H2O2)-induced cell death. Interestingly, NA–IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA–IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS.

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Section: Introductionmentioning

confidence: 99%

A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells

et al. 2018

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“…Superoxide anion radical-scavenging activity of GAYT was assessed by the method reported by Li et al [34] .The absorbance of the mixture was read at 560nm (As), mixture without GAYT samples was used as blank control (A0). Vit.C was considered as a positive control.…”

Section: Superoxide Anion Radical-scavenging Assaymentioning

confidence: 99%

Anti-fatigue Effects of Ginseng Antler Yam Tang Modulation of Oxidative Stress Signaling in a Mice Model

Miao

Zhang

Shao³

et al. 2020

Preprint

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Abstract Background: Ginseng Antler Yam Tang (GAYT), believe to invigorate “Qi” (vital energy), nourish “Blood” (body circulation) and engender “liquid” (body fluid), is a traditional Chinese medicine formula derived from the traditional prescription and Chinese traditional medicine partner theory. Methods: In this study, we aimed to evaluate the anti-fatigue effects of GAYT and its mechanisms are related to oxidative stress signaling using GAYT composition, in vitro and in vivo antioxidant, and biochemical index detection. Chemical components analysis of GAYT was performed by high performance liquid chromatography (HPLC) and ultraviolet spectrophotometry (UV). Results: The results show that the GAYT is rich in protein, total flavonoids, total polysaccharide and saponin. The mice model was treatment by GAYT (0.9, 1.8 and 3.6g/kg) for 4 weeks. GAYT treatment enhanced antioxidant activities. GAYT significantly enhances the exercise performance in weight-loaded swimming, rotating rod, and forced running test. Biochemical index levels showed that these effects were closely correlated with inhibiting the depletion of glycogen, blood lactic acid (LD) and adenosine triphosphate (ATP) stores, regulating oxidative stress-related parameters (superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and malonaldehyde (MDA)) in serum and liver of mice. Moreover, the results show that the effects of GAYT may be related with its regulation on the activations of AMP-activated protein kinase and protein kinase B in liver of mice.Conclusions: GAYT can induce recovery from fatigue in mice via the activation of the AMPK and AKT/mTOR pathways. Provide a theoretical basis for the study of GAYT's anti-fatigue effect

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“…Amino acid sequences are available for some purified toxins (Brinkman et al, 2014;Lassen et al, 2011Lassen et al, , 2012Li et al, 2012). DNA and RNA sequencing have been conducted for Carukia barnesi, Malo kingi (Avila Soria, 2009), and Aurelia aurita.…”

Section: Venomicsmentioning

confidence: 99%

Bioactive toxins from stinging jellyfish

Badré

2014

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Isolation, identification and characterization of a novel antioxidant protein from the nematocyst of the jellyfish Stomolophus meleagris

Cited by 33 publications

References 25 publications

A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells

A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells

Anti-fatigue Effects of Ginseng Antler Yam Tang Modulation of Oxidative Stress Signaling in a Mice Model

Bioactive toxins from stinging jellyfish

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