Isolation, Identification and Study of Antimicrobial Property of a Bioactive Compound in an Indian Medicinal Plant Acalypha indica (Indian-Nettle)

Solomon, Robinson David Jebakumar; Subramaniam, Kalidass; Jayaraj, Vimalan

doi:10.1007/s11274-005-1479-6

Cited by 18 publications

(9 citation statements)

References 24 publications

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“…Methanol was not considered because of its limited supply and Indian government has banned this solvent in ordinary use. The utilization of this diethyl ether and hexane for these plant species have been studied for the first time and the results obtained with these solvents are more significant in most of the cases against other methods (Jeevan Ram 2004;Jebakumar Solomon et al 2005). The reason for these results are not clear, but according to Nostro et al 2000, who has demonstrated that species such as Helichrysum italicum or Phytolocca dodecandra showed moderate activity against Escherichia coli when the diethyl extract obtained after extraction of the aqueous suspension of the drug powder was used, but that there were no active extracts or fractions against this bacteria when a sequential extraction with petroleum ether, dichloromethane, dichloromethane-methanol (9:1) and methanol were used supports our findings and suggests that the solvent and extraction system may both modify the final results.…”

Section: Discussionmentioning

confidence: 99%

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Studies on the efficiency of different extraction procedures on the anti microbial activity of selected medicinal plants

Muthuvelan

Raja

2008

World J Microbiol Biotechnol

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Many doubts still persist even today when it comes to selection of the solvents for extracting the active constituents from various Indian medicinal plants. This study was aimed at assessing and establishing the best solvent for extracting the active constituents from 10 plant extracts. Thin layer chromatography (TLC) was used to separate and establish the active constituents present in each of the medicinal plants. Active constituents from each plant were extracted by using three different solvent systems namely diethyl ether, chloroform and hexane and were tested against three species of gram negative and three species of gram positive bacteria (Escherichia coli, Pseudomonas aureginosa, Streptococcus pneumoniae, Aeromonas hydrophila, Staphylococcus aereus, Bacillus cereus) by means of agar well diffusion assay. Studies on the antioxidant activity studies were also carried out for these plant extracts by using Diphenylpicryl-hydrazyl (DPPH) method. For the antimicrobial activity, the study revealed that among the selected plants, Azadiracta indica, Pongamia pinnata, Aloe barbadensis had the maximum antibacterial activity. Among the extraction procedures diethyl ether was found to be the best solvent that could be used for the extraction procedure. On the antioxidant activity part, Coleus amboinicus and Calotropis procera were found to have high antioxidant activity of 91.64% and 88.72% respectively and the further results are reported and discussed.

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Section: Discussionmentioning

confidence: 99%

“…This was done to determine which solvent's extract had the maximum antibacterial activity. Only one spot that gave the best resolution was considered for further studies (Jebakumar Solomon et al 2005).…”

Section: Preparation Of Different Solvent Extractsmentioning

confidence: 99%

Studies on the efficiency of different extraction procedures on the anti microbial activity of selected medicinal plants

Muthuvelan

Raja

2008

World J Microbiol Biotechnol

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“…However, their studies involve the use of the whole plant and not a specific part of the plant. Another study from [10] has also showed that the methanol leaves extract of A. indica is most active against C. albicans compared to other extracts tested as it resulted in the highest inhibition zones against fungi. C. albicans was also proven to be susceptible towards chloroform and ethanol extracts compared to other fungi in a study conducted by [11].…”

Section: Antimicrobial Activitymentioning

confidence: 96%

In Vitro Study of Antimicrobial Activity of Acalypha Indica Linn. Extract

Ishak

So’ad²,

Jauhari³

et al. 2013

TOPROCJ

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The objective for this research undertaken was to evaluate Acalypha indica extracts for their antimicrobial potential. Fresh plant samples were extracted via maceration in increasing polarity using petroleum ether, chloroform and methanol. Antimicrobial activity of the extracts was assessed using disc diffusion assay and minimum inhibitory concentration. It was observed that the crude methanol leaves, stembark and chloroform stembark extracts exhibit antimicrobial activity towards both Staphylococcus aureus bacteria and Candida albicans fungi. The inhibition zones recorded in milimeters by the chloroform stembark extracts were 9.57±0.51 (200 mg/mL), 8.33±0.58 (100 mg/mL) and 7.33±0.58 (50 mg/mL) while methanol stembark extract recorded inhibition zones at 13.67±0.58 (200 mg/mL), 10.00±1.00 (100 mg/mL) and 9.33±0.58 (50 mg/mL) against S. aureus. Antifungal activity was also detected against C. albicans as the chloroform stembark extract produced inhibition zones of 14.33±0.58 (200 mg/mL), 13.33±0.58 (100 mg/mL) and 12.67±0.58 (50 mg/mL) while the methanol stembark extract resulted in inhibition zones of 15.33±0.58 (200 mg/mL), 14.33±0.58 (100 mg/mL) and 13.0±0.00 (50 mg/mL). In the case of crude methanol leaves extract, the extract produced inhibition zones of 19±0.58 (200 mg/mL), 13±1.00 (100 mg/mL) and 10±1.00 (50 mg/mL) against S. aureus while against C. albicans, the extract recorded inhibition zones of 15±0.58 (200 mg/mL), 14±0.00 (100 mg/mL) and 13±0.00 (50 mg/mL). The chloroform stembark crude extract developed a medium MIC value of 0.938 mg/mL while both methanol crude extracts produced a strong MIC value of 0.469 mg/mL during the minimum inhibition concentration screening against Candida albicans.

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“…Plants provide a wide range of secondary metabolites and essential oils that have an array of properties, including antimicrobial, allelopathical, bioregulatory, and antioxidative properties [142][143][144]. This class of plant derivatives is collectively referred to as biopesticides and includes the botanical fungicides [145].…”

Section: Botanical Fungicidesmentioning

confidence: 99%

Peach Brown Rot: Still in Search of an Ideal Management Option

2018

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Abstract:The peach is one of the most important global tree crops within the economically important Rosaceae family. The crop is threatened by numerous pests and diseases, especially fungal pathogens, in the field, in transit, and in the store. More than 50% of the global post-harvest loss has been ascribed to brown rot disease, especially in peach late-ripening varieties. In recent years, the disease has been so manifest in the orchards that some stone fruits were abandoned before harvest. In Spain, particularly, the disease has been associated with well over 60% of fruit loss after harvest. The most common management options available for the control of this disease involve agronomical, chemical, biological, and physical approaches. However, the effects of biochemical fungicides (biological and conventional fungicides), on the environment, human health, and strain fungicide resistance, tend to revise these control strategies. This review aims to comprehensively compile the information currently available on the species of the fungus Monilinia, which causes brown rot in peach, and the available options to control the disease. The breeding for brown rot-resistant varieties remains an ideal management option for brown rot disease control, considering the uniqueness of its sustainability in the chain of crop production.

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Isolation, Identification and Study of Antimicrobial Property of a Bioactive Compound in an Indian Medicinal Plant Acalypha indica (Indian-Nettle)

Cited by 18 publications

References 24 publications

Studies on the efficiency of different extraction procedures on the anti microbial activity of selected medicinal plants

Studies on the efficiency of different extraction procedures on the anti microbial activity of selected medicinal plants

In Vitro Study of Antimicrobial Activity of Acalypha Indica Linn. Extract

Peach Brown Rot: Still in Search of an Ideal Management Option

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