Isolation of 2-Pyridone Alkaloids from a New Zealand Marine-Derived Penicillium species

Abstract

Fermentation of a Penicillium sp. isolated from a surface-sterilized thallus segment of the brown alga Xiphophora gladiata, collected from Macrocarpa Point, Otago, New Zealand, in half-strength potato dextrose broth led to the isolation and characterization of three alkaloids: the known N-hydroxy-2-pyridone, PF1140 (1), and two new 2-pyridones, 2 and 3.

Marine natural products

“…Examination of the culture broth of Paecilomyces lilacinus, [sponge, Petrosia sp., (Jeju Is., S. Korea)] led to the This journal is ª The Royal Society of Chemistry 2011 HeLa cells, with brevione F 174 also inhibiting HIV-1 replication in C8166 cells. This represents the first isolation as a natural product 177. A Penicillium sp.…”

Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen

“…8A). The fungal pyridone alkaloids, such as PF1140, have a wide range of known biological activities, including antifungal and antibacterial activities (36–38). Asperphenamate is a peptidic natural product with anticancer activities and had been previously isolated from Penicillium sp.…”

Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106

“…Since marine fungi live in a biologically competitive environment with unique physical and chemical parameters, such as pH, temperature, pressure, oxygen, light, nutrients and salinity, the chemical diversity of the secondary metabolites and their range of applications from marine fungi is high [1,2,3,4,5,6,7]. Pyridone alkaloids characterized by a pyridine and a mono sesquiterpene in their structures are important microbial secondary metabolites [8]. Pyridoxatin 3 , a potent free radical scavenger with activity 20 times as active as vitamin E, was first reported by Teshima et al .…”