Isolation of a Crystalline Protein Possessing the Properties of Tobacco-Mosaic Virus

Stanley, W. M.

doi:10.1126/science.81.2113.644

Cited by 454 publications

(98 citation statements)

References 2 publications

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“…Due to the large size of the particles, a rich variety of experiments can be easily performed. Optical measurements show that some suspensions, such as the opals [1] and the viruses [2], form regular lattices that can, in principle, exhibit melting and structural phase transitions [3,4]. The elastic rigidity of these ordered structures leads to unusual viscoelastic properties.…”

Section: Introductionmentioning

confidence: 99%

Donnan equilibrium and the osmotic pressure of charged colloidal lattices

1998

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We consider a system composed of a monodisperse charge-stabilized colloidal suspension in the presence of monovalent salt, separated from the pure electrolyte by a semipermeable membrane, which allows the crossing of solvent, counterions, and salt particles, but prevents the passage of polyions. The colloidal suspension, that is in a crystalline phase, is considered using a spherical Wigner-Seitz cell. After the Donnan equilibrium is achieved, there will be a difference in pressure between the two sides of the membrane. Using the functional density theory, we obtained the expression for the osmotic pressure as a function of the concentration of added salt, the colloidal volume fraction, and the size and charge of the colloidal particles. The results are compared with the experimental measurements for ordered polystyrene lattices of two different particle sizes over a range of ionic strengths and colloidal volume fractions.

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Section: Introductionmentioning

confidence: 99%

Donnan equilibrium and the osmotic pressure of charged colloidal lattices

1998

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“…The crystallization of a virus, the tobacco mosaic virus, was first reported by Stanley (1935). Soon thereafter a number of small spherical plant viruses were crystallized and in 1944 X-ray diffraction patterns were obtained from dried crystals of a very small virus-like particle then called 'derivative' or 'protein' of the tobacco necrosis virus (TNV, Crowfoot & Schmidt, 1945).…”

Section: Introductionmentioning

confidence: 99%

Interpretation of the 10 Å rotation function of the satellite tobacco necrosis virus

Lentz¹,

Strandberg²

1974

Acta Cryst Sect A

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The rotation function calculated with 10 A three-dimensional data from monoclinic crystals of the satellite tobacco necrosis virus was fitted numerically to an icosahedral axis set. The r.m.s, angular deviation of the observed peak maxima from the calculated model axis set was 0.67 ° and the largest deviation was 1.4 °. Thus, there is no significant deviation from icosahedral symmetry at 10 A resolution. An investigation of the effects of the data inclusion limits and the radius of integration on the resolution of neighboring peaks in the rotation function showed that the best resolution was obtained by using only a thin shell of the highest-resolution data available and a radius of integration no larger than the estimated diameter of the virus protein subunit.

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“…Two decades later the reports by Gierer and Schramm (1956) [1] and Fraenkel-Conrat et al (1957) [2] demonstrated that the TMV infectivity resides in its RNA, i.e., that genetic information could be stored in RNA. The small size of viruses and their apparent simplicity, combined with the demonstration that they could be crystallized [3] led many to theorize that they represented a missing link between the mineral and living worlds and to the hypothesis that RNA was a primitive genetic polymer.…”

Section: Rna Is Older Than Dnamentioning

confidence: 99%

The RNA World and the origin of life: A short history of a tidy evolutionary narrative

Lazcano

2015

BIO Web of Conferences

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Isolation of a Crystalline Protein Possessing the Properties of Tobacco-Mosaic Virus

Cited by 454 publications

References 2 publications

Donnan equilibrium and the osmotic pressure of charged colloidal lattices

Donnan equilibrium and the osmotic pressure of charged colloidal lattices

Interpretation of the 10 Å rotation function of the satellite tobacco necrosis virus

The RNA World and the origin of life: A short history of a tidy evolutionary narrative

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