Isolation of an HIV-1 neutralizing peptide mimicking the CXCR4 and CCR5 surface from the heavy-chain complementary determining region 3 repertoire of a viremic controller

Chevigné, Andy; Delhalle, Sylvie; Counson, Manuel; Beaupain, Nadia; Rybicki, Arkadiusz; Verschueren, Charlène; Staub, Thérèse; Schmit, Jean-Claude; Seguin-Devaux, Carole; Deroo, Sabrina

doi:10.1097/qad.0000000000000925

Cited by 20 publications

(6 citation statements)

References 48 publications

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“…[36]Interventions combining HIV programming with peer education and sensitization training for health providers have been found to be effective in reducing sexual stigma among MSM in several contexts. [37,38] Fear of seeking healthcare was the one stigma indicator that was prevalent across all three stigma classes in this study. Therefore, sensitization training for health providers may have the potential to reach the broadest range of MSM in Nigeria and can have a profound impact in engaging MSM into HIV and STI prevention and care.…”

Section: Discussionmentioning

confidence: 86%

“…This collaboration, along with other “one-stop shop” models, have been successful at improving HIV testing and engagement with care among MSM. [26,37,56] This model could be improved by expanding to explicitly include services that address sexual stigma and other types of trauma experienced by clients. Approaches that are trauma-informed may be a promising method to mitigate sexual stigma and could address the intersectional nature of the issues of violence, gender, and HIV.…”

Section: Discussionmentioning

confidence: 99%

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Sexual Stigma Patterns Among Nigerian Men Who Have Sex with Men and Their Link to HIV and Sexually Transmitted Infection Prevalence

et al. 2017

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Sexual stigma facilitates the spread of HIV and sexually transmitted infections (STIs) but little is known about stigma affecting Nigerian men who have sex with men (MSM). We assessed patterns of sexual stigma across Nigerian MSM and their relationship to HIV and STIs. Data were collected from the TRUST/RV368 Study, a prospective cohort of 1480 Nigerian MSM enrolled from March 2013 to February 2016 using respondent driven sampling. Structural equation modeling was utilized to assess the association between stigma classes and HIV and STI prevalence, adjusting for participants' characteristics. A dose-response association was found between stigma class and HIV prevalence (27, 40, 55%, overall χ p < 0.001) and STI prevalence (15, 21, 24%, overall χ p = 0.011). These data suggest that stigma mitigation strategies, combined with increased engagement of MSM and retention in the HIV care continuum, need to be a component of interventions focused on reducing HIV transmission risks among MSM in Nigeria.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Sexual Stigma Patterns Among Nigerian Men Who Have Sex with Men and Their Link to HIV and Sexually Transmitted Infection Prevalence

et al. 2017

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“…Using a self-assembling peptide hydrogel to present inhibitory signals reduces dosing and costs, which are significant challenges to be solved in HIV microbicide development [261] . Another strategy is conjugating self-assembling peptides with mimetic peptides derived from the viral envelope proteins or receptors that neutralize HIV particles [262] , [263] . Self-assembling peptides conjugated with mimetic peptides in vivo can potentially bind and aggregate HIV particles.…”

Section: Discussionmentioning

confidence: 99%

Development of peptide inhibitors of HIV transmission

Shi

Nguyen

Cabral

et al. 2016

Bioactive Materials

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Treatment of HIV has long faced the challenge of high mutation rates leading to rapid development of resistance, with ongoing need to develop new methods to effectively fight the infection. Traditionally, early HIV medications were designed to inhibit RNA replication and protein production through small molecular drugs. Peptide based therapeutics are a versatile, promising field in HIV therapy, which continues to develop as we expand our understanding of key protein-protein interactions that occur in HIV replication and infection. This review begins with an introduction to HIV, followed by the biological basis of disease, current clinical management of the disease, therapeutics on the market, and finally potential avenues for improved drug development.

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“…These changes then expose gp120’s third variable loop ( i.e. V3 loop), which in turn interacts with CCR5 or CXCR4 [213–215]. The second interaction was suggested to occur in a two-site binding mechanism similar to that initially proposed for chemokines, with common interacting determinants [211].…”

Section: Beyond Canonical Chemokine Receptor Signalingmentioning

confidence: 99%

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model

Kleist

Getschman

Ziarek

et al. 2016

Biochemical Pharmacology

113

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Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions, and dysregulated CKR signaling underpins numerous disease processes of the immune system and beyond. CKRs, which belong to the seven transmembrane domain receptor (7TMR) superfamily, initiate signaling upon binding of endogenous, secreted chemokine ligands. Chemokine-CKR interactions are traditionally described by a two-step/two-site mechanism, in which the CKR N-terminus recognizes the chemokine globular core (i.e. site 1 interaction), followed by activation when the unstructured chemokine N-terminus is inserted into the receptor TM bundle (i.e. site 2 interaction). Several recent studies challenge the structural independence of sites 1 and 2 by demonstrating physical and allosteric links between these supposedly separate sites. Others contest the functional independence of these sites, identifying nuanced roles for site 1 and other interactions in CKR activation. These developments emerge within a rapidly changing landscape in which CKR signaling is influenced by receptor PTMs, chemokine and CKR dimerization, and endogenous non-chemokine ligands. Simultaneous advances in the structural and functional characterization of 7TMR biased signaling have altered how we understand promiscuous chemokine-CKR interactions. In this review, we explore new paradigms in CKR signal transduction by considering studies that depict a more intricate architecture governing the consequences of chemokine-CKR interactions.

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Isolation of an HIV-1 neutralizing peptide mimicking the CXCR4 and CCR5 surface from the heavy-chain complementary determining region 3 repertoire of a viremic controller

Abstract: The study provides evidence of the effectiveness and cost of a CPP along the HIV treatment cascade: access to HIV tests, awareness of HIV status, and antiretroviral therapy initiation.

Cited by 20 publications

References 48 publications

Sexual Stigma Patterns Among Nigerian Men Who Have Sex with Men and Their Link to HIV and Sexually Transmitted Infection Prevalence

Sexual Stigma Patterns Among Nigerian Men Who Have Sex with Men and Their Link to HIV and Sexually Transmitted Infection Prevalence

Development of peptide inhibitors of HIV transmission

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model

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