Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida

Falodun, Abiodun; Imieje, Vincent; Erharuyi, Osayemwenre; Ahomafor, Joy; Langer, Peter; Jacob, Melissa R.; Khan, Shabanna; Abaldry, Mohammed; Hamann, Mark T.

doi:10.12980/apjtb.4.2014c1312

Cited by 34 publications

(24 citation statements)

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“…A clerodane diterpene in L. donovani exhibited caspase-3/-7-like protease activity and genomic DNA fragmentation, induced mitochondrial dysfunction, and caused an oxidative stressmediated apoptotic cell death (Kathuria et al, 2014), while kaurenoic acid triggered the NLRP12/IL-1β/ cNOS/NO mechanism in Leishmania amazonensis (Miranda et al, 2015). A number of promising leishmicidal diterpenes have been reported (Sinha et al, 2000;Sairafianpour et al, 2001;Lala et al, 2003;Habtemariam, 2003;González et al, 2005;Fokialakis et al, 2006;Brito et al, 2006;Suryawanshi et al, 2008;Roy et al, 2010;Dos Santos et al, 2011;Mondal et al, 2013;Soares et al, 2013;Santos et al, 2013;Mothana et al, 2014;Moreira et al, 2014;Mokoka et al, 2014;Falodun et al, 2014;Demarchi et al, 2015;da Silva et al, 2015;Mizuno et al, 2015;Lima et al, 2015; Leprosy. It is also known as Hansen's disease, a longterm infection caused by the bacteria Mycobacterium leprae and Mycobacterium lepromatosis.…”

Section: Resultsmentioning

confidence: 99%

“…In some studies, diterpenes in nanoformulations (Roy et al, 2010;Mondal et al, 2013) as well as their laboratory derivatives have been reported to exhibit promising anti-NTDs activities (Watson and Preedy, 2010;Mander and Liu, 2010). Additionally, a number of diterpenes have been reported to act against multiple strains responsible for a particular NTD (Sanchez et al, 2006;Dea-Ayuela et al, 2016;Johnson et al, 1993;Riel et al, 2002;Clarkson et al, 2003;Kalauni et al, 2006;Ojo-Amaize et al, 2007;Wangchuk et al, 2010;González et al, 2014;Namukobe et al, 2015;Liu et al, 1997;Prabu et al, 2015;Encarnación-Dimayuga et al, 2006;Rijo et al, 2010;Arai et al, 2014;Xu et al, 2014a;Xu et al, 2014b) and NTDs (Schmidt et al, 2011;Al Musayeib et al, 2014;Ramírez-Macías et al, 2012;Mothana et al, 2014;Falodun et al, 2014;Mizuno et al, 2015;Mongkolvisut and Sutthivaiyakit, 2007;Rangkaew et al, 2009;Ospina and Rodríguez, 2009;Lekphrom et al, 2010;Almutairi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

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Diterpenes as lead molecules against neglected tropical diseases

et al. 2016

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Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor and developing areas in the world have received great attention to NTDs. Drug resistance, safety profile, and various challenges stimulate the search for alternative medications. Plant-based drugs are viewed with great interest, as they are believed to be devoid of side effects. Diterpenes, a family of essential oils, have showed attractive biological effects. A systematic review of the literature was carried out to summarize available evidences of diterpenes against NTDs. For this, databases were searched using specific search terms. Among the 2338 collected reports, a total of 181 articles were included in this review. Of them, 148 dealt with investigations using single organisms, and 33 used multiple organisms. No mechanisms of action were reported in the case of 164 reports. A total of 93.92% were related to nonclinical studies, and 4.42% and 1.66% dealt with preclinical and clinical studies, respectively. The review displays that many diterpenes are effective upon Chagas disease, chikungunya, echinococcosis, dengue, leishmaniasis, leprosy, lymphatic filariasis, malaria, schistosomiasis, and tuberculosis. Indeed, diterpenes are amazing drug candidates against NTDs. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diterpenes as lead molecules against neglected tropical diseases

et al. 2016

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“…Majority of the human race, especially from developing countries depend on the traditional system of medicine for the management of various diseases. 1 Thousands of plant species are used medicinally, chiefly as herbal preparations in the indigenous systems of medicine in different countries and are sources of safe, cheap and potent drugs which have continued to be effective, successful, popular and modern chemistry has not been able to substitute a good number of them 1 .Plants are natural reservoirs of medicinal agents which are widely assumed to be safe, but many are potentially toxic. 2 In spite of the millions of chemical compounds currently synthesized in the laboratory, and available for screening for the action of therapeutic value, natural products, *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Antiplasmodial and Acute Toxicity Studies of Fractions and Cassane-Type Diterpenoids from the Stem Bark of Caesalpinia pulcherrima (L.) Sw.

Ogbeide¹,

Dickson²,

Jebba³

et al. 2018

TJNPR

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Malaria is a major public health disease affecting millions of people worldwide especially in sub-Saharan Africa, with annual deaths of over 4 million. The emergence of resistant strains of Plasmodium parasite to currently used drugs necessitates the search for newer and affordable cure for malaria from medicinal plants sources. Caesalpinia pulcherrima (L) Sw. is used in traditional medicine for the treatment of various diseases including malaria. Phytochemical, acute toxicity studies and antiplasmodial activities were carried out on the stem bark extracts of the plant. Fraction (HEEA) was fractionated over silica gel column to obtain pure compounds (characterized by IR, UV, 1D and 2D spectroscopy) which were subjected to antiplasmodial investigations. Phytochemical studies revealed the presence of saponins, flavonoids, phenols, terpenoids, tannins, and alkaloids. The LD50 was established at 5656.85 mg/kg body weight in Swiss albino mice. Of all the fractions, HEEA exhibited the highest antiplasmodial activities against both the D6 and W2 Plasmodium falciparum clones at IC50 3.7 and 5.3µg /mL, respectively. Two known compounds; Pulcherrin J (1) and 6β-cinnamoyloxy-7β-hydroxyvouacapen-5α-ol (2) were isolated from HEEA and investigated for antiplasmodial activities. They showed significant inhibition of parasites growth in the D6 and W2 clones with IC50 values 10.25-˃10.62 µM and 10.25-˃10.62 µM, for compound 1 and 2, respectively, as against those of the standard antimalarial drugs (Chloroquine and Artemisinin) with IC50 values <0.0937 and <0.1062, respectively. These findings revealed that C. pulcherrima stem bark possess significant antiplasmodial activities and could be a promising source of newer antiplasmodial agents.

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“…Flavonoids of JML [46,47] or PIW [48] are potential for the conductive organic polymer. Initially, the conductive polymer is in/below the semiconductor range after oxidizing or reducing process [49].…”

Section: The Influence Of Agnps On Crystal Size and Conductivity Of Jmentioning

confidence: 99%

Modification of Electrical Properties of Silver Nanoparticle

Diantoro¹,

Suprayogi²,

Sa'adah³

et al. 2018

Silver Nanoparticles - Fabrication, Characterization and Applications

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This chapter focuses on the synthesis of silver nanoparticles (AgNPs), AgNP composites, and its role in the structure and electrical properties modification. The research and its various applications of nanoparticles are interesting among others. Silver nanoparticles (AgNPs) are now becoming to take an essential role in the diverse field of application.Establishing the simple and inexpensive of AgNPs is greatly required, since it will also influence it used. Many different methods to obtain AgNPs have been reported. The inducing AgNPs on a various number of other materials has been investigating. We report a brief review of simple AgNP fabrication method at different MSA, PEG, and ultrasonic irradiations regarding its structure and conductivity. We also report the influence of AgNPs on the electrical conductivity of conducting polymers, i.e., PANI, flavonoids of Jatropha multifida L. (JML) and Pterocarpus indicus W. (PIW). It is found that in general, the increase of AgNP concentration gives rise to increase of its electrical conductivity. The conductivity of the AgNPs doped of polymers does not directly reflect by its crystallinity or crystal size. Some exciting aspect of crystal structure and its conductivity are discussed.

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Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida

Abstract: The research lends support to the ethnomedicinal use of the plant in combating microbial infections, leishmaniasis and malarial infections.

Cited by 34 publications

References 12 publications

Diterpenes as lead molecules against neglected tropical diseases

Diterpenes as lead molecules against neglected tropical diseases

Antiplasmodial and Acute Toxicity Studies of Fractions and Cassane-Type Diterpenoids from the Stem Bark of Caesalpinia pulcherrima (L.) Sw.

Modification of Electrical Properties of Silver Nanoparticle

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