Antiplasmodial and Acute Toxicity Studies of Fractions and Cassane-Type Diterpenoids from the Stem Bark of Caesalpinia pulcherrima (L.) Sw.

Ogbeide, Osahon; Dickson, Vincent; Jebba, Randolph; Owhiroro, Dennis; Olaoluwa, Marvelous; Owolabi, Bodunde Joseph; Imieje, Vincent; Falodun, Abiodun; Fasinu, Pius S.

doi:10.26538/tjnpr/v2i4.5

Cited by 16 publications

(25 citation statements)

References 20 publications

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“…Caesalpinia pulcherrima (CP) is a flowering plant in the legume family fabaceae. They are normally grown as ornamental flowers in tropical gardens [18,19]. The plant is known to be a rich source of cassane-type diterpenoids, lupeol, lupeol acetate, carotenoids, quercetin, rutin, beta sitosterol, glycosides, phenols, steroids, flavonoids and alkaloids [19,[20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

“…They are normally grown as ornamental flowers in tropical gardens [18,19]. The plant is known to be a rich source of cassane-type diterpenoids, lupeol, lupeol acetate, carotenoids, quercetin, rutin, beta sitosterol, glycosides, phenols, steroids, flavonoids and alkaloids [19,[20][21][22][23]. Different researchers have reported the antiplasmodial activities of the leaves and stem bark of CP [19,21,22].…”

Section: Introductionmentioning

confidence: 99%

“…The plant is known to be a rich source of cassane-type diterpenoids, lupeol, lupeol acetate, carotenoids, quercetin, rutin, beta sitosterol, glycosides, phenols, steroids, flavonoids and alkaloids [19,[20][21][22][23]. Different researchers have reported the antiplasmodial activities of the leaves and stem bark of CP [19,21,22]. In these studies, the leaves of CP were shown to exhibit moderate antiplasmodial activity against Plasmodium berghei (PB), while the stem bark showed significant antiplasmodial effects [19,21].…”

Section: Introductionmentioning

confidence: 99%

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ANTIMALARIAL, FERRIC REDUCING ANTIOXIDANT POWER AND ELEMENTAL ANALYSIS OF Caesalpinia pulcherrima LEAF EXTRACT

Ogbeide¹,

Okhomina²,

Omoregie³

et al. 2020

JCSN

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The increasing rise of resistance of malaria parasites to established antimalarial drugs have necessitated the continued search for new drug entities especially those with fresh modes of action. Caesalpinia pulcherrima is a plant with many pharmacological and medicinal properties. The leaf extract and fractions were studied for their antimalarial, ferric reducing antioxidant power and elemental composition.Various fractions of the leaf extracts were obtained using vacuum liquid chromatography (VLC). The in vivo antimalarial activity was evaluated against plasmodium berghei parasites. The required dose was given according to the weight of the animal two hours after inoculation of parasites on D1, then once daily for three more days (D2-D4). The antioxidant activity was carried out using UV-Visible spectrometer at 593 nm. The elemental analysis was done using Atomic Absorption Spectrophotometer. There was a dose dependent increase in percentage chemo-suppression of the parasites by the different groups with maximum effect at 800 mg/kg (61.57-34.86 % from day five (5)to day eight (8) respectively). The highest FRAP activity was observed in 100% ethyl acetate with 314.90 ± 3.94 mmol, while the lowest antioxidant power was observed in 50% ethyl acetate:50% n-hexane fraction with 48.50 ± 1.10. 90%methanol:10% distilled water fraction did not indicate any FRAP activity. The results obtained revealed that the phytochemicals with very potent antioxidant power are more present in the ethyl acetate fraction. Elemental compositions (ppm) in the powdered leaf of C. pulcherrima were, sodium (Na); 20.27 ± 0.12, iron (Fe); 13.50 ± 0.08, calcium (Ca); 9.0 ± 0.14, and copper (Cu); 0.30 ± 0.08. Lead (Pb) was not detected. This study has shown that Lead concentration was below detectable limit, while the concentrations of Fe and Cu were within established permissible limits. Appreciable amount of Na and Ca were also indicated. C. pulcherrima leaf extract and fractions contain biologically active principles that are relevant antimalarial and antioxidant agents with acceptable mineral compositions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ANTIMALARIAL, FERRIC REDUCING ANTIOXIDANT POWER AND ELEMENTAL ANALYSIS OF Caesalpinia pulcherrima LEAF EXTRACT

Ogbeide¹,

Okhomina²,

Omoregie³

et al. 2020

JCSN

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show abstract

“…It has also been found to possess antioxidant, antiinflammatory and analgesic properties as well as prevention of chronic rheumatic disorder [8,9]. Many compounds have been isolated from different parts of the plant, including pulcherrin A, pulcherrin B, pulcherrimin A, pulcherrimin B, pulcherrimin C and many other cassane-type diterpenoids [10].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Assessment of Total Phenolic and Flavonoid Contents of Caesalpinia pulcherrima leaf Extract and Fractions

Ighodaro¹,

Ogbeide²

2020

JCSN

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Oxidative stress has been shown to play an important role in the development of many diseases. Indeed, the increase in total antioxidant status is imperative in the recuperation from these diseases. The antioxidant activity, total phenolic and flavonoid contents of Caesalpinia pulcherrima leaves were determined in this study. The powdered dried leaves of C. pulcherrima were screened for their effect on 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). Total phenolic and flavonoid contents of the extract and fractions were estimated using established methods. Concentrations of the plant extracts required for 50% inhibition of DPPH radical scavenging effect (IC50) were recorded as 3.20, 48.11, 33.12, 9.15, 27.26, 17.90, 272.18 and 55.51μg/ml for Ascorbic acid, 100% n-hexane, 50% n-hexane: 50% ethyl acetate, 100% ethyl acetate, 50% ethyl acetate:50% methanol, 100% methanol, 90% methanol:10% water fractions and crude extract, respectively. Total phenolic and flavonoid contents were highest for 100% ethyl acetate fraction. The leaf extract and fractions of C. pulcherrima exhibited notable radical scavenging activity and therefore corroborate its use as a natural plant antioxidant by preventing free radical damage.

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“…12 As a result, the discovery of new antimalarial drugs from the natural product can be a potential source to open new ways in the field of antimalaria therapy. [13][14][15][16][17] In addition, such compounds can be modified to get potential and safe antimalarial drugs. Some of the antimalarial © 2020 the authors.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antimalarial and Cytotoxic Activities of Sauropus androgynus Leaves Extracts

2020

TJNPR

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compounds from plants are alkaloids, terpenes, flavonoids, and xanthones. 14 The leaves of Sauropus androgynus from Euphorbiaceae family have been consumed as a highly nutritive food. S. androgynus leaves have been known to enhance breast milk production. They are also reported to function as antibacterial, analgesic, anti-inflammatory, antihypertensive, and wound healer. 18 Preliminary phytochemical analysis showed the presence of components such as tannins, flavonoids, alkaloids, and phenols in Sauropus androgynus. 19 Despite that, the antimalarial compound from the leaves of S. androgynus has not been reported before. This study focuses on the investigation of the in vitro antimalarial and cytotoxic activities of n-hexane, chloroform, and 96% ethanol extracts of S. androgynus leaves. Furthermore, the various extracts were screened for the presence of plant secondary metabolites. Materials and Methods Plant materials Leaves of S. androgynus were collected by Dr. Husin Rayesh Mallaleng in January 2018 and identified by Materia Medica Batu, East Java. The voucher specimen was deposited at Faculty of Pharmacy, Universitas Airlangga with herbarium number 074/68/102.7/2018. Extraction Dried leaves of S. androgynus (960 g) were extracted with 4.8 L nhexane by maceration (3x 24 hours) at room temperature. Subsequently, the marc was successively extracted with 4.8 L chloroform, and 4.8 L 96% ethanol. All filtrates from each solvent were evaporated separately with a rotary evaporator to obtain the crude extracts and the yields were calculated. 20,21

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Antiplasmodial and Acute Toxicity Studies of Fractions and Cassane-Type Diterpenoids from the Stem Bark of Caesalpinia pulcherrima (L.) Sw.

Cited by 16 publications

References 20 publications

ANTIMALARIAL, FERRIC REDUCING ANTIOXIDANT POWER AND ELEMENTAL ANALYSIS OF Caesalpinia pulcherrima LEAF EXTRACT

ANTIMALARIAL, FERRIC REDUCING ANTIOXIDANT POWER AND ELEMENTAL ANALYSIS OF Caesalpinia pulcherrima LEAF EXTRACT

Antioxidant Activity and Assessment of Total Phenolic and Flavonoid Contents of Caesalpinia pulcherrima leaf Extract and Fractions

In Vitro Antimalarial and Cytotoxic Activities of Sauropus androgynus Leaves Extracts

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