Isolation of Erythroidine, an Alkaloid of Curare Action, From Erythrina Americana Mill.

Folkers, Karl; Major, Randolph T.

doi:10.1021/ja01287a509

Cited by 65 publications

(29 citation statements)

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“…Erythrina americana ( Fig. 1) are containing the typical alkaloids exhibiting the same curare-like activity reported before (Folkers & Unna, 1939;Folkers & Major, 1937). Moreover, his group succeeded in isolation the first erythrinane alkaloid named erythroidine (14, Fig.…”

Section: Introductionsupporting

confidence: 60%

“…Thus, the natives of South America used concentrated extracts of these species as arrow poisons as antidote against strychnine or as an hypnotic and antiepileptic (Folkers & Unna, 1938). Also was observed that when is applied to dogs at different doses an alcoholic extract of seeds of E. americana provoked a similar activity to that of tubocurarine, this action was confirmed later on (Lozoya & Lozoya, 1982) The first crystalline alkaloid pharmacologically active was isolated from E. americana (Folkers & Major, 1937) called erythroidine. Altamirano used this name but he related it as a unknown constituent of the plant.…”

Section: Pharmacologymentioning

confidence: 89%

See 1 more Smart Citation

Erythrina, a Potential Source of Chemicals from the Neotropics

Soto-Hernández¹,

García-Mateos²,

Miguel-Chávez³

et al. 2012

Bioactive Compounds in Phytomedicine

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Section: Introductionsupporting

confidence: 60%

Section: Pharmacologymentioning

confidence: 89%

Erythrina, a Potential Source of Chemicals from the Neotropics

Soto-Hernández¹,

García-Mateos²,

Miguel-Chávez³

et al. 2012

Bioactive Compounds in Phytomedicine

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“…Later, van Romburgh and Barger (1911) proved hypaphorine to be a betaine of tryptophan. Hypaphorine has also been isolated from other species of Erythrina (Maranon, Santos, 1932;Folkers, Major, 1937), during attempts to isolate substances with curare-like action, known to be present in some species of Erythrina. Hypaphorine, however, does not possess curare-like action but produces hyperactivity in frogs (Plugge, 1893).…”

Section: Introductionmentioning

confidence: 99%

Crystal and molecular structure of l-hypaphorine hydroiodide

Jones¹,

Tiekink²

1997

Zeitschrift Für Kristallographie - Crystalline Materials

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The crystal and molecular structure of L-hypaphorine hydroiodide, C14H19IN2O2, has been determined at room temperature. The colorless crystals are tetragonal, space group P4\, with unit cell dimensions a = 7.168(2) A, c = 30.497(9) A, Z = 4 and Dx = 1.586 Mg m~3. The structure was solved by direct methods and refined by a full-matrix least-squares procedure on F to final R = 0.029 using 877 reflections. The structure determination shows that the indole ring is almost perpendicular to the roughly planar Cy-G3-C"-N" chain. The lattice is stabilised by I... H hydrogen bonding interactions.

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“…These include the Erythrina alkaloids isolated from the Coral Tree (Erythrina crista-galli) and other members of the genus (Folkers and Major, 1937;Tsuda and Sano, 1996). β-Dihydroerythroidine, erysodine, and erythraline are shown in Fig.…”

Section: Competitive Antagonistsmentioning

confidence: 99%

Nicotinic Agonists, Antagonists, and Modulators From Natural Sources

2005

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1. Acetylcholine receptors were initially defined as nicotinic or muscarinic, based on selective activation by two natural products, nicotine and muscarine. Several further nicotinic agonists have been discovered from natural sources, including cytisine, anatoxin, ferruginine, anabaseine, epibatidine, and epiquinamide. These have provided lead structures for the design of a wide range of synthetic agents. 2. Natural sources have also provided competitive nicotinic antagonists, such as the Erythrina alkaloids, the tubocurarines, and methyllycaconitine. Noncompetitive antagonists, such as the histrionicotoxins, various izidines, decahydroquinolines, spiropyrrolizidine oximes, pseudophrynamines, ibogaine, strychnine, cocaine, and sparteine have come from natural sources. Finally, galanthamine, codeine, and ivermectin represent positive modulators of nicotinic function, derived from natural sources. 3. Clearly, research on acetylcholine receptors and functions has been dependent on key natural products and the synthetic agents that they inspired.

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Isolation of Erythroidine, an Alkaloid of Curare Action, From Erythrina Americana Mill.

Cited by 65 publications

References 0 publications

Erythrina, a Potential Source of Chemicals from the Neotropics

Erythrina, a Potential Source of Chemicals from the Neotropics

Crystal and molecular structure of l-hypaphorine hydroiodide

Nicotinic Agonists, Antagonists, and Modulators From Natural Sources

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