Isolation of Flavonoids and Triterpenoids from the Fruits of <i>Alphitonia Neocaledonica</i> and Evaluation of their Anti‐oxidant, Anti‐tyrosinase and Cytotoxic Activities

Muhammad, Dima; Hubert, Jane; Lalun, Nathalie; Renault, Jean‐Hugues; Bobichon, Hélène; Nour, Mohammed; Voutquenne-Nazabadioko, Laurence

doi:10.1002/pca.2545

Cited by 32 publications

(37 citation statements)

References 27 publications

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“…BP-4, a soluble UVB filter, can stabilise EGCG to produce effective anti-oxidants. Catechin preparations made with lipid ingredients are less stable in heat, so it is necessary to Gallego et al 2017, Spizzirri et al 2009, Nadim et al 2014, Feng et al 2014, Feng et al 2013, Zhong and Shahidi 2011, Muhammad et al 2014, Li and Seeram 2018, Choi et al 2018, Shoko et al 2018, Lima et al 2016 UV protection Improve the stability of catechins in sunlight and increase the UV protection effect Zhang et al 2016, Yoshino et al 2013, Niu et al 2017, Huang et al 2007, Martincigh and Ollengo 2016, Parisi et al 2012, Kim et al 2012, Xia et al 2005 Anti-microbial activities Demonstrates anti-microbial activity and develops pharmaceuticals and functional cosmetics de Oliveira et al 2017, Aoshima et al 2009, Goyal et al 2017 Anti-allergenic and antiinflammatory activities…”

Section: Discussionmentioning

confidence: 99%

“…Lipophilized EGCG derivatives show increased anti-oxidant activity (Zhong and Shahidi 2011). Flavonoids and triterpenoids from the fruit of Alphitonia neocaledonica have cytotoxicity, anti-oxidant, and anti-tyrosinase activities and are useful cosmetic ingredients (Muhammad et al 2014). Approximately 106 phenolic compounds have been found using liquid chromatography assays coupled with electrospray ionisation for rapid profiling of phenolic compounds from red maple (Acer rubrum) leaves (Li and Seeram 2018).…”

Section: Introductionmentioning

confidence: 99%

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Activity of catechins and their applications

et al. 2020

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Background: Catechins, which are polyphenol compounds found in many plants and are an important component of tea leaves, are strong anti-oxidants. Research: Many studies seek to enhance the effects of catechins on the human body and boost their protective power against UV radiation. There are many examples of the positive anti-microbial, anti-viral, anti-inflammatory, anti-allergenic, and anti-cancer effects of catechins. Catechins increase the penetration and absorption of healthy functional foods and bio cosmetics into the body and the skin, thus improving their utility. High value-added antioxidant substances have been extracted from food and plant sludge, and experiments have shown that catechins are safe when applied to the human body. The stability of catechins is very important for their absorption into the human body and the effectiveness of their anti-oxidant properties.Conclusion: Continued research on the strong anti-oxidant effects of catechins is expected to result in many advances in the food, cosmetics, and pharmaceutical industries.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Activity of catechins and their applications

et al. 2020

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“…13 Thus, increased attention is now turned to natural antioxidants such as those of phytochemicals which are relatively safer, more abundant and have the stronger efficiency to scavenge free radicals compared to synthetic antioxidants. 14 prostaglandin biosynthesis and replication on herpes simplex virus type-1. 14,[16][17][18][19][20] Alphitonia philippinensis Braid is vernacularly known by the Malays in Brunei Darussalam as "balik angin".…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant Activity and Phytochemical Screening of Leaves, Barks, Stems and Fruits of Alphitonia philippinensis (Rhamnaceae) From Brunei Darussalam

Ahmed¹,

Salim²,

Lim³

et al. 2019

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Alphitonia, a genus of the Rhamnaceae family with, approximately 20 species, are available in the tropical regions of Southeast Asia, Polynesia and Oceania. 15,16 This genus is mainly used in traditional medicine by the inhabitants of Samoa, Fiji, Tahiti, Vanuatu, Tonga, Northern Australia and Brunei Darussalam for coughs, constipation, headaches, stomachaches, menstrual pain, prolapsed rectum after postpartum woman, facilitate childbirth, swelling, fever, earache, cancer, skin diseases (eczema, ecthyma, pityriasis), inflammation, rheumatic pains, ulcer, gastrointestinal and urogenital disorders. 16-19 Isolation of a range of bioactive compounds were reported from this genus having antioxidant, antimicrobial, cytotoxic, antiulcer, antityrosinase, inhibitions of ABSTRACT Phytochemical screening of Alphitonia philippinensis extracts revealed the presence of cardiac glycosides, tannins, saponins and steroids in different plant parts. Total phenolic content (TPC), total flavonoid content (TFC) and total flavonol content (TFlC) were measured using spectrophotometric methods where gallic acid and quercetin were the standards. Antioxidant activity of extracts was assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azino-bis(3ethylbenzothiazoline-6-sulfonic acid) (ABTS), free radical scavenging and ferric reducing antioxidant power (FRAP) assays using ascorbic acid and trolox were used as standards. Among the four different crude methanol extracts studies, leaves showed highest antioxidant capacity. EC 50 values of the leaves extract from DPPH and ABTS method found 32 and 45 µg/mL respectively. The higher antioxidant activity of the leaves extract could be correlated with the presence of higher total phenolic content, total flavonoid, and total flavonol contents. According to antioxidant contents and assay results leaves extract possesses highest antioxidant property following fruits, barks and stems.

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“…The antioxidant activities of some compounds were measured in the DPPH radical scavenging assay with a slight modification of the reported method (Muhammad et al 2015). Briefly, 150 mL of 0.2 mM DPPH prepared in MeOH were added to 96-well dishes with compounds at different concentrations.…”

Section: Acid Hydrolysis Of Compound 1and Determination Of Sugarmentioning

confidence: 99%

A new phenolic compound with antioxidant activity from the branches and leaves of Pyrus pashia

Zheng

Wan

et al. 2015

Natural Product Research

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The branches and leaves of Pyrus pashia are used to cure abdominal pain and diarrhoea in Chinese folk medicine. A new phenilic compound, 4-O-β-d-glucopyranosylbenzyl-benzoate ester (1), along with 21 known ones (2-22) were isolated from the branches and leaves of this plant. Compounds 2 and 3 displayed remarkable antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl radical (IC50 = 13.26 ± 0.04 μM, 13.28 ± 0.11 μM, respectively), which were at the same grade as positive control rutin. The caffeoyl group in compounds 2 and 3 was supposed to play an important role in the antioxidant activities.

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Isolation of Flavonoids and Triterpenoids from the Fruits of Alphitonia Neocaledonica and Evaluation of their Anti‐oxidant, Anti‐tyrosinase and Cytotoxic Activities

Cited by 32 publications

References 27 publications

Activity of catechins and their applications

Activity of catechins and their applications

Evaluation of Antioxidant Activity and Phytochemical Screening of Leaves, Barks, Stems and Fruits of Alphitonia philippinensis (Rhamnaceae) From Brunei Darussalam

A new phenolic compound with antioxidant activity from the branches and leaves of Pyrus pashia

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