Isolation of flavonoids from the aerial parts of Polygala tenuifolia Willd. and their antioxidant activities

Shi, Tianxing; Li, Yuguang; Jiang, Yong; Tu, Pengfei

doi:10.5246/jcps.2013.01.004

Cited by 11 publications

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“…The Clinical Manual of Traditional Chinese Medicine indicated that the medicinal sections of APT are the stem and leaves, which are prescribed using the name 'Xiaocao' (13). APT contains various active ingredients, including flavonoids and phenolic glycosides, which were reported to serve anti-inflammatory and anti-oxidative effects (14,15). However, whether APT improves learning and memory in AD animal models is yet to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of the aerial parts of <em>Polygala tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice

et al. 2020

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Alzheimer's disease is a common neurodegenerative disease characterized by progressive cognitive dysfunction and behavioral impairment. Aerial parts of Polygala tenuifolia Willd (APT) is a traditional Chinese medicine used for the treatment of amnesia. The present study aimed to investigate the protective effects of APT on scopolamine-induced learning and memory impairments in mice. Scopolamine-induced mice were used to determine the effects of APT on learning and memory impairment. Mice were orally administered with APT (25, 50 and 100 mg/kg) and piracetam (750 mg/kg) for 14 days, and intraperitoneally injected with scopolamine (2 mg/kg) from days 8 to 14. Morris water maze and step-down tests were performed to evaluate learning and memory. Levels of acetylcholine (ACh), choline acetyltransferase (ChAT), acetylcholinesterase (AChE), interleukin (IL)-1β, IL-10 and brain-derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex were measured by ELISA. Superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione (GSH) were measured via biochemical detection. The results demonstrated that APT ameliorated learning and memory impairment in scopolamine-induced mice. Correspondingly, APT significantly increased ACh and ChAT levels in the hippocampus and prefrontal cortex of scopolamine-induced mice. Additionally, treatment with APT significantly increased BDNF and IL-10 levels, and decreased IL-1β and AChE levels in the same mice. Furthermore, APT significantly increased SOD activity and GSH content, and decreased MDA levels in brain tissue. These results indicated that APT may ameliorate learning and memory impairment by regulating cholinergic activity, promoting BDNF and inhibiting neuroinflammation and oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of the aerial parts of <em>Polygala tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice

et al. 2020

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“…However, there are differences in the structure of ginsenosides and polygalasaponin (senegenin): the basic nucleus of the polygala saponin is an oleanolic acid-type pentacyclic triterpenoid, and the two types are the dammaranetype tetracyclic triterpenoid saponin and the oleanolic acidtype pentacyclic triterpenoid saponin, respectively (14), such as the protopanaxadiol saponin Rb1 (15,16) and the original ginseng triol-type saponin Rg1 (17,18) (Figures 1I,J). Senegenin (Figure 1C) is treated as the mother nucleus of the polygala saponins and can be linked to different sites, including sugars (12,17,19,20) such as onjisaponin B (Figure 1D) and tenuifolin (Figure 1E), as reported in the previous studies (21,22).…”

Section: Polygala Saponinsmentioning

confidence: 71%

Protective Effects and Mechanism of Radix Polygalae Against Neurological Diseases as Well as Effective Substance

et al. 2021

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Radix Polygalae (also known as Yuanzhi in China) is the dried rhizome of Polygala tenuifolia Willd. or Polygala sibirica L., which is a famous Chinese herb and has been widely used for centuries in traditional medicines including expectorants, tonics, tranquilizers, antipsychotic, and so on. This article reviews the neuroprotective effects of Radix Polygalae in preclinical models of central nervous system (CNS) disorders, especially anxiety, depression, declining cognition, Alzheimer's disease (AD), and Parkinson's disease (PD). The chemical composition of Radix Polygalae as well as the underlying mechanisms of action were also reviewed. We found that Radix Polygalae possesses a broad range of beneficial effects on the abovementioned conditions. The multifold mechanisms of action include several properties such as antioxidant and associated apoptotic effects; anti-inflammatory and associated apoptotic effects; neurogenesis, regeneration, differentiation, and neuronal plasticity improvement; hypothalamic–pituitary–adrenal axis (HPA) regulation; neurotransmitter release; and receptor activation (A2AR, NMDA-R, and GluR). Nevertheless, the detailed mechanisms underlying this array of pharmacological effects observed in vitro and in vivo still need further investigation to attain a coherent neuroprotective profile.

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“…By comparison of the physical and spectral data with those reported in the literature, the six known compounds (2 -7) were identified: quercetin-3-O-b-D-xyloside (2) (Seto et al 1992;Yin et al 2005), quercetin-3 0 -O-a-L-rhamnoside (3) (Dong & Jia 2005), quercetin (4) (Shi et al 2013), pinocembrin-7-O-b-D-glucoside (5) (Zhao et al 2012), pinocembrin (6) (Zhou et al 2002) and gallic acid (7) (Yang et al 1999) (Figure 1). …”

Section: Resultsmentioning

confidence: 99%

A new flavanone from the aerial parts of Penthorum chinense

Wang

Jiang²,

Liu

et al. 2014

Natural Product Research

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Isolation of flavonoids from the aerial parts of Polygala tenuifolia Willd. and their antioxidant activities

Cited by 11 publications

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Neuroprotective effects of the aerial parts of <em>Polygala tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice

Neuroprotective effects of the aerial parts of <em>Polygala tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice

Protective Effects and Mechanism of Radix Polygalae Against Neurological Diseases as Well as Effective Substance

A new flavanone from the aerial parts of Penthorum chinense

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Isolation of flavonoids from the aerial parts of Polygala tenuifolia Willd. and their antioxidant activities

Cited by 11 publications

References 0 publications

Neuroprotective effects of the aerial parts of <em>Polygala&nbsp;tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice

Neuroprotective effects of the aerial parts of <em>Polygala&nbsp;tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice

Protective Effects and Mechanism of Radix Polygalae Against Neurological Diseases as Well as Effective Substance

A new flavanone from the aerial parts of Penthorum chinense

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Neuroprotective effects of the aerial parts of <em>Polygala tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice

Neuroprotective effects of the aerial parts of <em>Polygala tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice