Isolation of Galegine From Verbesina enceloiodes

Eudesmane Derivatives from Verbesina turbacensis

“…Compound 5 + ) and 13 C-NMR (BB and DEPT) spectral data, the molecular formula of 5 was deduced to be C 24 H 34 O 4 . These data, as well as 2D-NMR experiments, revealed that 5 is a 6β-[cinnamoyloxy]-eudesmane sesquiterpene similar to 1, with an additional secondary hydroxyl group (δ H 3.10 (-OH) and 3.44 (H-C-O-); δ C 78.84), but in which, the C-15 carboxyl group was replaced by a methyl (δ H 1.14; δ C 17.92) located on a carbon that supports a tertiary hydroxyl group (δ C 75.18).…”

“…IR spectra were taken on a PerkinElmer FT-1725X spectrophotometer as film or KBr pellets. 1 H, 13 C and two-dimensional NMR spectra were measured on a Bruker-Avance DRX400 instrument, using CDCl 3 as solvent with TMS as internal standard. EI-MS and HREI-MS were run on a Hewlett-Packard 5930A and on an Autospec VG spectrometer, respectively; direct inlet, 70 eV.…”

“…1,8 Several species also afforded elemanolides, 9,10 diterpenes, 11 flavonoids, 12 and biological active guanidines as Galegine, the toxic principle of V. enceloides Benth. 13,14 As a continuation of our phytochemical investigation on Venezuelan Compositae, [15][16][17] in this paper we describe the results of our study of Verbesina turbacensis H.B.K., a previously uninvestigated species, which is widely distributed throughout of Central America from Mexico to Colombia and Venezuela. 18 V. turbacensis as well as V. caracasana Fries, a plant which contains the dosedependent hypotensive agent Caracasanamide, 19 are frequently used in Venezuela as medicinal plants against a variety of diseases.…”

Pharmacological evaluation of Verbesina encelioides

“…A. Grey, has been least investigated for the biological effects of its extracts. Apart from some work concerning toxicity (Kingsbury, 1964;Oelrichs et al, 1981;Eichholzer et al, 1982), and several chemical analysis, e.g., primary metabolites (Jain and Purohit, 1985), sesquiterpenes (Joshi et al, 1983), flavonol glycosides (Glennie and Jain, 1980) and triterpenoids (Tiwari et al, 1978;Jain et al, 1980), little work has been published on the pharmacological effects of extracts from this species.…”

“…Each of these was tested for antitumour activity. Dry powdered flowers, its ethanolic extract and isolated galegine, i.e., (3-methylbut-2-en-l-yl) guanidine following the method of Oelrichs et al (1981) and ethanolic extract fraction enriched in P-cyanins obtained from roots were tested 7 Author to whom correspondence should be addressed.…”