Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties

Samarakoon, Sameera Ranganath; Fernando, Narmada; Ediriweera, Meran Keshawa; Adhikari, Achyut; Wijayabandara, Lakshan; Silva, E; Tennekoon, Kamani Hemamala

doi:10.9734/bjpr/2016/23317

Cited by 3 publications

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“…Several flavonoids, terpenoids and iridoids have been isolated from S. hydrophyllacea by previous researchers [9]. Cytotoxic and apoptotic properties of leaf and bark extracts of S. hydrophyllacea and isolation of hopenone-I from the hexane leaf extract of S. hydrophyllacea have reported in our previous studies [10,11]. The present study was aimed at to isolate cytotoxic compound/s in the active hexane and chloroform extracts of S. hydrophyllacea leaves and to evaluate their cytotoxic effects in nonsmall cell lung (NCI-H292) and breast cancer (MCF-7) cells.…”

Section: Introductionmentioning

confidence: 92%

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Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Samarakoon¹,

Ediriweera²,

Wijayabandara³

et al. 2018

Trop. J. Pharm Res

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and two-dimensional nuclear magnetic resonance (2D-NMR) and electron ionization-mass spectrometry (EI-MS) techniques. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the cytotoxic effects of the compounds on oestrogen receptor positive breast (MCF-7) and non-small cell lung (NCI-H-292) cancer cells. Results: The isolated compounds were identified as oleanolic acid (1), ursolic acid (2) and eichlerianic acid (3). Ursolic acid and eichlerianic acid showed strong cytotoxic effects {IC50-ursolic acid: 8.47 µg/mL (24 h, MCF-7), 7.78 µg/mL (24 h, NCI-H292) and eichlerianic acid: 8.86 µg/mL (24 h, MCF-7), 10.15 µg/mL (24 h, NCI-H292)} in MCF-7 and NCI-H292 cancer cells at 24, 48 and 72 h post-incubation periods. Conclusion: Hexane and chloroform extracts of the leaves of S. hydrophyllacea yielded three compounds namely oleanolic acid, eichlerianic acid and ursolic acid. Ursolic acid and eichlerianic acid have been isolated for the first time from the leaves of S. hydrophyllacea grown in Sri Lanka and demonstrate in-vitro cytotoxic effects in oestrogen receptor positive (MCF-7) and non-small lung cancer (NCI-H-292) cells.Keywords: Scyphiphora hydrophyllacea, eichlerianic acid, ursolic acid, oleanolic acid, This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest

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Section: Introductionmentioning

confidence: 92%

“…Leaves of S. hydrophyllacea were collected from the same plant used for our previous studies [10,11]. Leaves of the plant were collected from the National Aquatic Resources Research and Development Agency (NARA) Negombo, Sri Lanka and the plant material was identified by Mr. W.A.…”

Section: Collection Of Plant Materialsmentioning

confidence: 99%

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Samarakoon¹,

Ediriweera²,

Wijayabandara³

et al. 2018

Trop. J. Pharm Res

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“…Amongst the most relevant are: cardiovascular protection, immune system modulation, the prevention of some types of cancer and rheumatoid arthritis, and the prevention of hair loss [88]. Hopenone is an uncommon triterpenoid ketone with an anti-proliferative action, which is deemed potentially useful for cancer prevention [90,91]. Amongst steroids, ecdysone septanoside-derivatives showed antioxidant activity, the inhibition of cholinesterase (potentially functional for preventing hypertension and related heart disease) and a mild inhibiting activity against some bacteria strains of interest [49].…”

Section: Human Nutritionmentioning

confidence: 99%

Functional Food from Endangered Ecosystems: Atriplex portulacoides as a Case Study

Zanella

Vianello

2020

Foods

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Biodiversity is a reservoir of potential sources of novel food and feed ingredients with suitable compositions for the improvement of the diet and well-being of humans and farmed animals. The halophyte Atriplex portulacoides occurs in habitats that are exposed to seawater inundations, and shows biochemical adaptations to saline and oxidative stresses. Its composition includes long chain lipids, sterols, phenolic compounds, glutathione and carotenoids. These organic compounds and micronutrients, such as Fe, Zn, Co and Cu, make this plant suitable as an optimal functional food that is potentially able to reduce oxidative stress and inflammatory processes in humans and animals. Indeed, many of these compounds have a protective activity in humans against cardiovascular pathologies, cancer, and degenerative processes related to aging. The analysis of its history as food and forage, which dates back thousands of years, attests that it can be safely consumed. Here, the limits of its chemical and microbiological contamination are suggested in order to comply with the European regulations. The productivity of A. portulacoides in natural environments, and its adaptability to non-saline soils, make it a potential crop of high economic interest.

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Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells

Samarakoon¹,

Shanmuganathan²,

Ediriweera³

et al. 2016

EJMP

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Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties

Cited by 3 publications

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Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Functional Food from Endangered Ecosystems: Atriplex portulacoides as a Case Study

Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells

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