Isolation of lupeol acetate from fruit peels of Artocarpus camansi

Nasution, Rosnani; Muhabbah, Nurul; Helwati, Hira; Bahi, Muhammad; Marianne, Marianne; Amna, Ulil

doi:10.4103/japtr.japtr_6_20

Cited by 7 publications

(8 citation statements)

References 11 publications

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“…Flavonoid compounds that bind to enzymes alter the active site of the enzyme, making it harder to recognize by the substrate and interfering with the enzyme-substrate interaction. Nasution et al (2015) [41] discovered that betasitosterol compounds derived from the bark of the A. camansi plant may decrease blood sugar levels in male Swiss Webster rats. Idris et al (2022) [42] discovered that methanol extract from the leaves of the Rhodomyrtus tomentosa plant has antidiabetic effects of 82.41 ± 2.21% against α-amylase inhibition and 81.91 ± 1.09% against αglucoamylase inhibition.…”

Section: -5-antidiabetic Testmentioning

confidence: 99%

Cycloartobiloxanthone, a Flavonoid with Antidiabetic, Antibacterial and Anticancer Activities from Artocarpus kemando Miq.

Suhartati,

Prihatin,

Kurniati

et al. 2024

Emerg Sci J

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In this present work, a cycloartobiloxanthone compound was isolated from the stem wood and root bark of the Pudau plant (Artocarpus kemando Miq.). The purity of the compound was determined using thin-layer chromatography with three eluent systems and melting point tests. The sample was then analyzed using UV-Vis, IR, and NMR spectroscopy, ensuring that the compound is cycloartobilox-anthone. The cycloartobiloxanthone compound was obtained in a yellow crystalline form with a melting point of 285.1-294°C. The compound was then investigated for antidiabetic, anticancer, and antibacterial properties, showing that the compound has an anti-diabetic effect by reducing the activity of the α-amylase enzyme, with the highest percentage of inhibition of 48.53 ± 1.84% achieved with the use of 1000 ppm of the compound. Cycloartobiloxanthone isolated has an IC50 value of 9.21 µg/mL for anticancer activity against MCF-7 cells, indicating that the compound shows active cytotoxic actions. Staphylococcus aureus was very strongly inhibited by the compound in the antibacterial test at all doses, whereas for Salmonellasp., the activity was categorized as moderate at concentrations of 0.4 and 0.3 mg/disc and strong at 0.5 mg/disc. The anti-diabetic, anti-cancer, and antibacterial bioactivity studies indicated that the cycloartobiloxanthone compound isolated has a broad spectrum of pharmacological actions, indicating that the compound has promising potential. Doi: 10.28991/ESJ-2024-08-01-04 Full Text: PDF

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Section: -5-antidiabetic Testmentioning

confidence: 99%

Cycloartobiloxanthone, a Flavonoid with Antidiabetic, Antibacterial and Anticancer Activities from Artocarpus kemando Miq.

Suhartati,

Prihatin,

Kurniati

et al. 2024

Emerg Sci J

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“…Polyprenol, cycloartenol, cycloartenol acetate were isolated from the stems. The seeds found in the fruit are also a source of lectin while the triterpenoid, lupeol acetate were isolated from the fruit peels [23][24][25][26]. The identified chemical constitutes is shown in Figure 1.…”

Section: Phytochemistrymentioning

confidence: 99%

<em></em><em>Artocarpus Camansi</em> Blanco: A Review on Its Traditional Use, Nutritional Value, Phytochemistry, and Pharmacology

Bicaldo¹

2022

Preprint

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Artocarpus camansi Blanco or breadnut (Family: Moraceae) is primarily found in tropical regions of the world. Different parts of the plant provide potential use in medicine, nutraceutical development, and livelihood. The present review attempts to document literature on the traditional use, nutritional value, phytochemistry, and pharmacological investigation carried out with breadnuts. The included literatures of the plant were collected from various sources and databases like Google scholar, PubMed, ScienceDirect, Crossref, and Scopus. Breadnuts are rich in secondary metabolites. Studies have reported the isolation of several triterpenoid compounds and the broad spectrum of its pharmacological activities such as antidiabetic, antimalarial, antioxidant, anti-tumor, antibacterial, and immunomodulatory properties. The approximate composition of the seed and the fruit also highlights the nutritional importance of this plant. A. camansi Blanco is an underutilized tree that holds significant potential if further research and sustainable conservation is applied. Efforts to mainstream its use as functional food and increase awareness among the locals should also be given attention.

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“…Bagian batang menghasilkan poliprenol dan sikloartenol asetat. Bagian kulit yang diekstrak dengan n-heksan mengandung β-amyrin asetat dan sikloeugenol [29,30].…”

Section: Kluwihunclassified

“…Ekstrak air dari biji dan daun kluwih menunjukkan aktivitas yang kuat (50-100 µg/mL), kulit buah kluwih memiliki aktivitas yang sedang (101-150 µg/mL), dan daging buah kluwih memiliki aktivitas yang rendah (>150 µg/mL) [63]. Senyawa yang berperan sebagai antioksidan antara lain β-sitosterol pada daun, sikloartenol asetat pada batang, β-amyrin asetat dan sikloeugenol pada kulit [29,30].…”

Section: Aktivitas Antioksidanunclassified

Profil Fitokimia dan Aktivitas Antioksidan Beberapa Tumbuhan Genus Artocarpus di Indonesia

et al. 2021

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Artocarpus merupakan tumbuhan genus utama keluarga Moraceae dengan jumlah spesies hampir 1.400. Beberapa spesies dari genus tersebut dapat dimanfaatkan sebagai makanan dan obat tradisional di Asia Tenggara, termasuk Indonesia. Jenis yang banyak tumbuh di Indonesia yaitu Artocarpus altilis (sukun), Artocarpus camansi (kluwih), Artocarpus heterophyllus (nangka), Artocarpus integer (cempedak), dan Artocarpus odoratissimus (tarap). Tumbuhan tersebut memiliki potensi sebagai bahan obat dan punya nilai gizi yang tinggi. Review ini bertujuan untuk mengkaji perbedaan antar spesies, profil fitokimia, dan aktivitasnya sebagai antioksidan dari kelima tumbuhan tersebut. Narrative review ini ditulis berdasarkan penelusuran literatur yang berupa publikasi artikel penelitian yang ada di basis data Google Scholar, PubMed, dan Science Direct. Selain itu digunakan sumber pustaka lain berupa buku dan naskah tugas akhir untuk memperkaya isi artikel. Hasil kajian literatur terhadap 5 tumbuhan tersebut menunjukkan bahwa beberapa tumbuhan memiliki kemiripan morfologi daun walaupun secara fisik masih bisa dibedakan. Profil fitokimianya memiliki keunikan dengan kandungan utama berupa senyawa fenolik termasuk flavonoid, stilbenoid, arilbenzofuron, dan neolignan yang tersebar pada bagian daun, buah, bunga, dan kulit. Keunikan tersebut ditemui dengan adanya senyawa golongan flavonoid terprenilasi dan tergeranilasi. Senyawa fenolik tersebut mempunyai kemampuan sebagai antioksidan pada beberapa model uji dan potensial untuk dikembangakan sebagai antioksidan atau kandidat obat terutama untuk penyakit yang melibatkan mekanisme radikal bebas dalam mekanisme patofisiologinya.

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Isolation of lupeol acetate from fruit peels of Artocarpus camansi

Cited by 7 publications

References 11 publications

Cycloartobiloxanthone, a Flavonoid with Antidiabetic, Antibacterial and Anticancer Activities from Artocarpus kemando Miq.

Cycloartobiloxanthone, a Flavonoid with Antidiabetic, Antibacterial and Anticancer Activities from Artocarpus kemando Miq.

<em></em><em>Artocarpus Camansi</em> Blanco: A Review on Its Traditional Use, Nutritional Value, Phytochemistry, and Pharmacology

Profil Fitokimia dan Aktivitas Antioksidan Beberapa Tumbuhan Genus Artocarpus di Indonesia

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