Isolation of marine crab (Charybdis natator) leg muscle peptide and its anti-inflammatory effects on macrophage cells

Narayanasamy, Aarthi; Balde, Akshad; Raghavender, Prasanna; Shashanth, D.; Abraham, Joshua; Joshi, Ila; Nazeer, R. A.

doi:10.1016/j.bcab.2020.101577

Cited by 54 publications

(16 citation statements)

References 27 publications

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“…Moreover, crab-derived peptides can restrain the inflammatory process by reducing inflammatory mediators’ levels and modulating the NF-kB pathway, implicated in various inflammatory diseases [ 107 ]. Besides their role as an anti-inflammatory substance, these crustacean-derived peptides can exert antinociceptive effects, consequently playing a role in pain control as potent COX-2 reducers in vitro [ 108 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory activities of arthropod peptides: a systematic review

Santos

Cruz

Baptista

2021

J. Venom. Anim. Toxins incl. Trop. Dis

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Section: Resultsmentioning

confidence: 99%

Anti-inflammatory activities of arthropod peptides: a systematic review

Santos

Cruz

Baptista

2021

J. Venom. Anim. Toxins incl. Trop. Dis

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“…NSAIDs are a common treatment for inflammation, both chronic and acute. While NSAIDs are an invaluable tool in combating inflammation, problems arise when used to treat chronic inflammation over long periods of time, the risk of associated gastric bleeding, ulceration, renal failure, and a myriad of other side effects can occur [ 24 , 25 , 40 ]. Anti-inflammatory BAPs have been proposed as a gentler alternative to NSAIDs [ 29 , 41 ].…”

Section: Chronic Inflammationmentioning

confidence: 99%

“…LMW fish- and shellfish-derived protein products were reported in studies from Ahn et al, Gao et al, Saisavoey et al, Siregar et al, and Subhan et al [ 44 , 59 , 63 , 65 , 70 ]. Studies by Joshi et al, Joshi and Nazeer, Kim et al, Narayanasamy et al [ 24 , 48 , 56 , 61 ] found bioactive products in fractions >5 kDa. The study by Durand et al, 2020 [ 43 ] found two anti-inflammatory BAPs, with one being >5 kDa and one being <5 kDa.…”

Section: Fish and Shellfish-derived Anti-inflammatory Protein Products: Properties And Mechanismsmentioning

confidence: 99%

“…Therefore, fish- and shellfish-derived protein products are an important area of research in the effort to treat inflammation both chronic and acute, and to mitigate damage from inflammation-related diseases. Marine-derived peptides have previously been found to possess anti-oxidant, anti-tumor, anti-hypertensive, angiotensin-converting-enzyme (ACE) inhibitory, immunomodulatory, antidiabetic, antimicrobial, anticoagulant, and anti-inflammatory potential [ 1 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Fish and Shellfish-Derived Anti-Inflammatory Protein Products: Properties and Mechanisms

Kemp

Kwon

2021

Molecules

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The interest in utilizing food-derived compounds therapeutically has been rising. With the growing prevalence of systematic chronic inflammation (SCI), efforts to find treatments that do not result in the side effects of current anti-inflammatory drugs are underway. Bioactive peptides (BAPs) are a particularly promising class of compounds for the treatment of SCI, and the abundance of high-quality seafood processing byproducts (SPB) makes it a favorable material to derive anti-inflammatory BAPs. Recent research into the structural properties of anti-inflammatory BAPs has found a few key tendencies including they tend to be short and of low molecular weight (LMW), have an overall positive charge, contain hydrophobic amino acids (AAs), and be rich in radical scavenging AAs. SPB-derived anti-inflammatory BAPs have been observed to work via inhibition of the NF-κB and MAPK pathways by disrupting the phosphorylation of IκBα and one or more kinases (ERK, JNK, and p38), respectively. Radical scavenging capacity has also been shown to play a significant role in the efficacy of SPB-derived anti-inflammatory BAPs. To determine if SPB-derived BAPs can serve as an effective treatment for SCI it will be important to understand their properties and mechanisms of action, and this review highlights such findings in recent research.

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“…As marine organisms live in a special environment that is hypersaline, high-pressure, hypoxia, and hypothermic, and lacks sunlight, these proteins and peptides have strong bioactivities and a specific structure. There are many effects associated with marine peptides, such as antioxidant, antimicrobial, antitumor, antiviral, cardioprotective, immunomodulatory, and tissue regeneration properties [ 16 , 30 , 31 , 32 ]. Approximately 49 marine-derived active substances or their derivatives have been approved for the market or entered clinical trials globally [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Small Peptides of Marine Origin in Cancer Therapy

et al. 2021

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Cancer is one of the leading causes of death in the world, and antineoplastic drug research continues to be a major field in medicine development. The marine milieu has thousands of biological species that are a valuable source of novel functional proteins and peptides, which have been used in the treatment of many diseases, including cancer. In contrast with proteins and polypeptides, small peptides (with a molecular weight of less than 1000 Da) have overwhelming advantages, such as preferential and fast absorption, which can decrease the burden on human gastrointestinal function. Besides, these peptides are only connected by a few peptide bonds, and their small molecular weight makes it easy to modify and synthesize them. Specifically, small peptides can deliver nutrients and drugs to cells and tissues in the body. These characteristics make them stand out in relation to targeted drug therapy. Nowadays, the anticancer mechanisms of the small marine peptides are still largely not well understood; however, several marine peptides have been applied in preclinical treatment. This paper highlights the anticancer linear and cyclic small peptides in marine resources and presents a review of peptides and the derivatives and their mechanisms.

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Isolation of marine crab (Charybdis natator) leg muscle peptide and its anti-inflammatory effects on macrophage cells

Cited by 54 publications

References 27 publications

Anti-inflammatory activities of arthropod peptides: a systematic review

Anti-inflammatory activities of arthropod peptides: a systematic review

Fish and Shellfish-Derived Anti-Inflammatory Protein Products: Properties and Mechanisms

Recent Advances in Small Peptides of Marine Origin in Cancer Therapy

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