Isolation of meclofenamic acid and two metabolites from equine urine — a comparison between horse and man

Johansson, Ingvar; Anlér, Eva-Lotta; Bondesson, Ulf; Schubert, B.

doi:10.1016/0731-7085(86)80039-5

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…, 1985; Johansson et al. , 1991) and metabolism (Johansson et al. , 1986) have already been studied in the horse.…”

Section: Design Of the Experimentsmentioning

confidence: 99%

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Spurious urine excretion drug profile in the horse due to bedding contamination and drug recycling: the case of meclofenamic acid

Popot¹,

Menaut²,

Boyer³

et al. 2007

Vet Pharm & Therapeutics

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“…, 1985; Johansson et al. , 1991) and metabolism (Johansson et al. , 1986) have already been studied in the horse.…”

Section: Design Of the Experimentsmentioning

confidence: 99%

“…Hence for i.v. application, meclofenamic acid (Sigma, Saint Quentin Fallavier, France) was dissolved at a concentration of 10% in a mixture of PEG 400/water (25/75, v/v solution, as described by Johansson et al. , 1986, 1991).…”

Section: Design Of the Experimentsmentioning

confidence: 99%

Spurious urine excretion drug profile in the horse due to bedding contamination and drug recycling: the case of meclofenamic acid

Popot¹,

Menaut²,

Boyer³

et al. 2007

Vet Pharm & Therapeutics

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“…A reversed-phase high-performance liquid chromatographic method (HPLC) was developed to analyse meclofenamic acid in equine plasma (Johansson & Eklund, 1984). T w o metabolites of meclofenamic acid were found, both in plasma and in urine, and were identified as alcoholic (oxidation of the 3methyl group to the hydroxymethyl) and phenolic (hydroxylation of the B-ring) metabolites (Johansson et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Studies of meclofenamic acid and two metabolites in horses‐pharmacokinetics and effects on exercise tolerance

Johansson

Kallings

Hammarlund‐Udenaes

1991

Vet Pharm & Therapeutics

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The pharmacokinetics and the effects on treadmill exercise of the anti-inflammatory drug meclofenamic acid were studied in seven Standardbred horses after single intravenous and/or oral doses. The decline in plasma concentration after a single intravenous dose of meclofenamic acid (2.2 mg/kg b.wt) was described by a two-compartment open model. The average elimination half-life was 1.4 h, the apparent volume of distribution 0.14 l/kg and the plasma clearance 0.12 l/h kg. Absorption was the rate-limiting step after oral administration. Non-compartmental analysis showed a mean absorption time of 4.3 h. The pharmacokinetics of two metabolites of meclofenamic acid were also studied in two of the horses. The elimination half-lives of the two metabolites were virtually the same in each horse (3.0 h and 3.4 h). The blood lactate response to exercise was significantly decreased after treatment with meclofenamic acid, indicating a lower utilization of the glycolytic ('anaerobic') energy contribution during exercise. Circulatory capacity was apparently unaffected with an unchanged heart rate response to exercise.

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High resolution gas chromatography determination of twelve acidic non‐steroidal antiinflammatory drugs (NSAIDs) as methyl ester derivatives in plasma

Giachetti¹,

Zanolo²,

Poletti³

et al. 1990

J. High Resol. Chromatogr.

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Isolation of meclofenamic acid and two metabolites from equine urine — a comparison between horse and man

Cited by 5 publications

References 8 publications

Spurious urine excretion drug profile in the horse due to bedding contamination and drug recycling: the case of meclofenamic acid

Spurious urine excretion drug profile in the horse due to bedding contamination and drug recycling: the case of meclofenamic acid

Studies of meclofenamic acid and two metabolites in horses‐pharmacokinetics and effects on exercise tolerance

High resolution gas chromatography determination of twelve acidic non‐steroidal antiinflammatory drugs (NSAIDs) as methyl ester derivatives in plasma

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