Isolation of natural compounds from Phlomis stewartii showing α-glucosidase inhibitory activity

Jabeen, Bushra; Riaz, Naheed; Saleem, Muhammad; Naveed, Muhammad Akram; Ashraf, Muhammad; Alam, Umber; Rafiq, Hafiza Mehwish; Tareen, Rasool Bakhsh; Jabbar, Abdul

doi:10.1016/j.phytochem.2013.09.015

Cited by 59 publications

(32 citation statements)

References 20 publications

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“…The a-glucosidase inhibitory activity of compound 3 was higher than those of compounds 1 and 2 possibly because it consisted of more hydroxyl groups and the removal of hydroxyls in flavonoids has been shown to decrease a-glucosidase inhibitory activity [31] . The higher a-glucosidase inhibitory activity of compound 3 was also in accordance with tiliroside isolated from Phlomis stewartii [32] . This result showed that Q. gilva is a potential source for a supplement to replace pharmaceutical antidiabetic drugs in the future because it contains active compounds that act as a-glucosidase inhibitors.…”

Section: Discussionsupporting

confidence: 73%

Antioxidant and α-glucosidase inhibitor activities of natural compounds isolated from Quercus gilva Blume leaves

Indrianingsih

Tachibana

Dewi

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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Objective: To isolate and investigate antioxidant and a-glucosidase inhibitor compounds in the leaves of Quercus gilva Blume (Q. gilva). Methods: Dry leaves of Q. gilva were extracted with methanol and the methanolic extract was further separated by silica gel column chromatography using several solvents with increasing polarity. The antioxidant activities of the isolated compounds were evaluated using various in vitro assays: 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, hydrogen peroxide radical scavenging activity, b-carotene bleaching assay, and reducing power assay. The a-glucosidase inhibitory assay was conducted against aglucosidase from Saccharomyces cerevisiae. Results: Three compounds were isolated and their structures were identified as catechin (1), epicatechin (2), and tiliroside (3) using an instrumental analysis. Compound 2 had higher antioxidant activity with inhibitory concentrations (IC 50 ) of (22.55 ± 2.23) mmol/L than that of quercetin, which was used as the standard, with an IC 50 of (28.08 ± 2.39) mmol/L, followed by compound 1 with IC 50 of (40.86 ± 3.45) mmol/L. On the other hand, compound 3 had the lowest antioxidant activity with an IC 50 of (160.24 ± 8.15) mmol/L. However, compound 3 had the highest a-glucosidase inhibitory activity with an IC 50 of (28.36 ± 0.11) mmol/L, followed by compounds 1 and 2 with (168.60 ± 5.15) and (920.60 ± 10.10) mmol/L, respectively. Conclusions: The results obtained for the antioxidant activities and a-glucosidase inhibitory activities in a methanolic extract from the leaves of Q. gilva confirmed the potential of this plant as a source of natural antioxidants and antidiabetic medicine.

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Section: Discussionsupporting

confidence: 73%

Antioxidant and α-glucosidase inhibitor activities of natural compounds isolated from Quercus gilva Blume leaves

Indrianingsih

Tachibana

Dewi

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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“…The activity of stewartiiside (314) (IC 50 = 26.1 ± 0.3 mol/L) was comparable with that of lunariifolioside (315) (IC 50 = 26.6 ± 0.2 mol/L). This means that the glycone part did not played an important role in enzyme inhibition [14].…”

Section: Phenylpropanoidsmentioning

confidence: 93%

“…Three abietane diterpenoids (14)(15)(16) were isolated from methanol extract of Plectranthus madagascariensis and exhibited α-glucosidase inhibitory activity with IC 50 values of 274.9 ± 12.3, 108.2 ± 1.3, and 142.7 ± 1.4 mol/L, respectively [9].…”

Section: Terpenesmentioning

confidence: 99%

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α-Glucosidase inhibitors isolated from medicinal plants

Yin

Zhang

Feng

et al. 2014

Food Science and Human Wellness

366

233

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Objective: α-Glucosidase inhibitors can be used as a new class of antidiabetic drug. By competitively inhibiting glycosidase activity, these inhibitors help to prevent the fast breakdown of sugars and thereby control the blood sugar level. This study provides a wealth of information about α-glucosidase inhibitors isolated from medicinal plants; this knowledge will be useful in finding more potent antidiabetic candidates from the natural resources for the clinical development of antidiabetic therapeutics. Results: 411 compounds exhibiting α-glucosidase inhibitory activity were summarized and isolated them from medicinal plants. The compound classes isolated include: terpenes (61) from 14 genus, alkaloids (37) from 11 genus, quinines (49) from 4 genus, flavonoids (103) from 24 genus, phenols (37) from 9 genus, phenylpropanoids (73) from 20 genus, sterides (8) from 5 genus, and other types of compounds (43). Conclusion: Compounds with α-glucosidase inhibitory activity are abundant in nature and can be obtained from several sources. They have high α-glucosidase inhibitory potential, and can be clinically developed for treating diabetes mellitus.

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“…They have various uses that differ from one country to another. [12] [13] According to our knowledge, no documented reports on the antibacterial activity and chemical composition of essential oils from different populations of P. olivieri growing in Western provinces of Iran are available. [6] The genus Phlomis is represented by 17 species in flora Iranica.…”

Section: Introductionmentioning

confidence: 99%

Variation in Chemical Composition and Antibacterial Activity of the Essential Oil of Wild Populations of Phlomis olivieri

Bajalan

Rouzbahani

Pirbalouti

et al. 2017

Chemistry & Biodiversity

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Various species of the genus Phlomis have been reported to produce metabolites demonstrating significant pharmacological efficiency. In this study, the essential oils from twelve populations of Phlomis olivieri collected from natural habitats were investigated for their chemical components. The hydrodistillated essential oil analyzed by GC-FID and GC/MS. Analyses revealed 27 compounds, constituting 90.52 - 98.51% of the essential oils. Results indicated that the major components of the essential oils from various populations of P. olivieri were germacrene D (26.54 - 56.41%), bicyclogermacrene (6.38 - 30.55%), β-caryophyllene (5.32 - 24.52%) and α-pinene (1.29 - 15.53%). Principal component analyses (PCA) was used to identify any geographical variations in essential oil composition. Notably, three groups of Iranian P. olivieri populations were determined according to the major compounds. Results of the in vitro antibacterial activity indicated that P. olivieri essential oils showed good inhibitory activities against bacteria, especially Bacillus subtilis. The results of this study gave new insights for cultivation and industrial uses of P. olivieri in Iran.

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Isolation of natural compounds from Phlomis stewartii showing α-glucosidase inhibitory activity

Cited by 59 publications

References 20 publications

Antioxidant and α-glucosidase inhibitor activities of natural compounds isolated from Quercus gilva Blume leaves

Antioxidant and α-glucosidase inhibitor activities of natural compounds isolated from Quercus gilva Blume leaves

α-Glucosidase inhibitors isolated from medicinal plants

Variation in Chemical Composition and Antibacterial Activity of the Essential Oil of Wild Populations of Phlomis olivieri

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