Isolation of natural herbicidal compound from <i>Lantana camara</i>

Qureshi, Huma; Anwar, Tauseef; Ali, Shafaqat; Haider, Muhammad Zulqurnain; Habib, Noman; Fatima, Sammer; Waseem, Muhammad; Bibi, Yamin; Arshad, Muhammad; Adkins, Steve W.

doi:10.1080/03067319.2019.1670822

Cited by 16 publications

(11 citation statements)

References 24 publications

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“…parts are used in folk medicine against fever, cancer, influenza, skin sores, chickenpox, measles, asthma, leprosy, rheumatism, and hypertension [3]. Some of these uses were proven by several studies, which reported that the leaf extracts demonstrated anti-inflammatory [4], anticancer [5], antibacterial [6], antifungal, insecticidal [7], and nematocidal activities [2]. Externally, the leaf extract is applied to the skin to heal ulcers [8] and eczema exacerbations.…”

Section: Introductionmentioning

confidence: 99%

Comparative LC–LTQ–MS–MS Analysis of the Leaf Extracts of Lantana camara and Lantana montevidensis Growing in Egypt with Insights into Their Antioxidant, Anti-Inflammatory, and Cytotoxic Activities

El-Din

Fahmy

et al. 2022

Plants

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Lantana camara L. and Lantana montevidensis Briq. (F. Verbenaceae) are invasive ornamental weeds native to the tropical regions of Africa and America. The leaves of both species have been traditionally used as infusions for treating fever, rheumatism, and cancer. LC–MS–MS-guided profiling of the methanolic extracts of the leaves of L. camara and L. montevidensis growing in Egypt led to the putative identification of 59 compounds belonging to terpenoids, flavonoids, iridoid glycosides, phenolic acids, and their derivatives. The in-vitro antioxidants and anti-inflammatory and anticancer activities of the two extracts were investigated. L. camara and L. montevidensis inhibited DPPH• (IC50 = 34.01 ± 1.32 and 47.43 ± 1.74 µg/mL), ABTS+ (IC50 = 30.73 ± 1.42 and 40.37 ± 1.51 µg/mL), and superoxide anion (IC50 = 1.57 ± 0.19 and 1.31 ± 0.14 μg/mL) free radicals. A potent anti-inflammatory effect was observed for both species through the inhibition of elastase release in fMLF/CB-induced human neutrophils (IC50 = 2.40 ± 0.16 and 1.90 ± 0.07 μg/mL). The extracts showed significant cytotoxic activity against a panel of cancer cell lines with the most potent activity against Caco cells (IC50 = 45.65 ± 1.64 and 40.67 ± 1.52 µg/mL for L. camara and L. montevidensis, respectively). Western blotting supported by FACS analysis revealed that the extracts inhibited cancer cell proliferation, reduced metastasis, and induced apoptosis resulting in cell cycle arrest. This was achieved via increasing mRNA and protein expressions of p53 and GSK-3β as well as decreasing the expression of PI3K, Akt, and cyclin D1.

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Section: Introductionmentioning

confidence: 99%

Comparative LC–LTQ–MS–MS Analysis of the Leaf Extracts of Lantana camara and Lantana montevidensis Growing in Egypt with Insights into Their Antioxidant, Anti-Inflammatory, and Cytotoxic Activities

El-Din

Fahmy

et al. 2022

Plants

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“…In the present study, all the annotated metabolites in S. apetala leaves’ methanolic extracts were reported for the first time, except for vitexin (Sa M3), which was found to be a major constituent (along with gallic acid and isorhamnetin) in the branches and leaves of S. apetala collected in China [ 50 ]. A recent study allowed researchers to identify this flavone glucoside as an allelochemical with natural herbicide activities against Phalaris minor , Avena fatua , Chenopodium album and Rumex dentatus growth through the bio-guided fractionation of Lantana camara leaves’ extracts [ 80 ]. Reversely, Kalinova et al [ 81 ] tested the effect of vitexin on eight plant species and showed no effect or a stimulative effect on their growth.…”

Section: Discussionmentioning

confidence: 99%

Allelopathic Potential of Mangroves from the Red River Estuary against the Rice Weed Echinochloa crus-galli and Variation in Their Leaf Metabolome

Dhaou

Baldy

Tan

et al. 2022

Plants

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Mangroves are the only forests located at the sea–land interface in tropical and subtropical regions. They are key elements of tropical coastal ecosystems, providing numerous ecosystem services. Among them is the production of specialized metabolites by mangroves and their potential use in agriculture to limit weed growth in cultures. We explored the in vitro allelopathic potential of eight mangrove species’ aqueous leaf extracts (Avicennia marina, Kandelia obovata, Bruguiera gymnorhiza, Sonneratia apetala, Sonneratia caseolaris, Aegiceras corniculatum, Lumnitzera racemosa and Rhizophora stylosa) on the germination and growth of Echinochloa crus-galli, a weed species associated with rice, Oryza sativa. Leaf methanolic extracts of mangrove species were also studied via UHPLC-ESI/qToF to compare their metabolite fingerprints. Our results highlight that A. corniculatum and S. apetala negatively affected E. crus-galli development with a stimulating effect or no effect on O. sativa. Phytochemical investigations of A. corniculatum allowed us to putatively annotate three flavonoids and two saponins. For S. apetala, three flavonoids, a tannin and two unusual sulfated ellagic acid derivatives were found. Some of these compounds are described for the first time in these species. Overall, A. corniculatum and S. apetala leaves are proposed as promising natural alternatives against E. crus-galli and should be further assessed under field conditions.

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“…However, no phytotoxic activity of methyl palmitate from L.camara flowers has ever been identified. These compounds may have inhibitory effects on ATP generation and electron transport in chloroplasts and mitochondria, similar to other phytotoxins ( Qureshi et al, 2021 ). Allelochemicals usually work through pathways that synthetic compounds don't, making natural compounds a potential source of new herbicide leads.…”

Section: Discussionmentioning

confidence: 99%

Bioherbicidal ability and weed management of allelopathic methyl esters from Lantana camara

Anwar

Qureshi

Mahnashi

et al. 2021

Saudi Journal of Biological Sciences

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Allelochemicals are secondary metabolites which are not edible and can be used as growth regulators and bio-herbicides. The goal of current study was to assess allelopathic ability of Lantana camara (Sage-plant) flowers against weeds viz. Avena fatua (Wild oat), Euphorbia helioscopia (Sun-spurge), Chenopodium album (Goosefoot), Phalaris minor (Canary-grass), and Rumex dentatus (Knotweed). Bioassay analysis of three methanolic fractions of the Combi flash from L. camara was performed at 50%, 75% and 100% concentration using germination percentage parameters, inhibition of plumule and radicle size. The fraction II of Combi flash strongly suppressed all weeds with negligible effect on T. aestivum . Gas chromatography-mass spectroscopy was conducted for the fraction, and isolated compounds were used to perform bioassays. From fraction II GC–MS detected four methyl esters of allelopathic fatty acid viz. Methyl oleate, methyl palmitate, methyl stearate and methyl linoleate. The evaluation of physiological effects of the bioassay revealed substantial suppression of chlorophyll, antioxidant enzymes (superoxide, dismutase peroxidase) and protein material in all weeds by methyl palmitate. Bioassay activity and study of physiological parameters revealed that the effective bio-herbicidal compound in Lantana camara flowers is methyl palmitate. This is the first time that methyl palmitate (a fatty acid methyl ester) has been related to herbicidal activity in L. camara flowers. It is proposed that field studies based on hormesis research and the mechanism of action of this compound be carried out.

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Isolation of natural herbicidal compound from Lantana camara

Cited by 16 publications

References 24 publications

Comparative LC–LTQ–MS–MS Analysis of the Leaf Extracts of Lantana camara and Lantana montevidensis Growing in Egypt with Insights into Their Antioxidant, Anti-Inflammatory, and Cytotoxic Activities

Comparative LC–LTQ–MS–MS Analysis of the Leaf Extracts of Lantana camara and Lantana montevidensis Growing in Egypt with Insights into Their Antioxidant, Anti-Inflammatory, and Cytotoxic Activities

Allelopathic Potential of Mangroves from the Red River Estuary against the Rice Weed Echinochloa crus-galli and Variation in Their Leaf Metabolome

Bioherbicidal ability and weed management of allelopathic methyl esters from Lantana camara

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