Isolation of Outer Membrane Vesicles from Helicobacter pylori

Windle, Henry J.

doi:10.1007/978-1-0716-1302-3_13

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…It was seen that multi-serotype OMVs produce a higher immune response than single-serotype OMVs [ 45 ]. Thus, OMVs can stimulate a strong immune response yet save bacteria by protecting them with anti-inflammatory molecules [ 46 ]. Meningococcal OMVs stimulate dendritic cells via high expression of CD40, CF83, CD80, CD86, and IL-6 1L1-beta [ 47 ].…”

Section: Uptake Of Omvs By Host Cellsmentioning

confidence: 99%

“…In addition, CD4+T and CD8+T cell responses are also triggered by OMVs [ 55 ]. OMVs can also suppress T cell response, Neisseria meningitides can negatively impact T cell production by changing the receptors [ 46 ]. Proteins on the OMVs bind to human carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) on CD4+ T cells and inhibit them.…”

Section: Uptake Of Omvs By Host Cellsmentioning

confidence: 99%

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Outer Membrane Vesicles: An Emerging Vaccine Platform

et al. 2022

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Vaccine adjuvants are substances that improve the immune capacity of a recombinant vaccine to a great extent and have been in use since the early 1900s; they are primarily short-lived and initiate antigen activity, mainly an inflammatory response. With the developing technologies and innovation, early options such as alum were modified, yet the inorganic nature of major vaccine adjuvants caused several side effects. Outer membrane vesicles, which respond to the stressed environment, are small nano-sized particles secreted by gram-negative bacteria. The secretory nature of OMV gives us many benefits in terms of infection bioengineering. This article aims to provide a detailed overview of bacteria’s outer membrane vesicles (OMV) and their potential usage as adjuvants in making OMV-based vaccines. The OMV adjuvant-based vaccines can be a great benefactor, and there are ongoing trials for formulating OMV adjuvant-based vaccines for SARS-CoV-2. This study emphasizes engineering the OMVs to develop better versions for safety purposes. This article will also provide a gist about the advantages and disadvantages of such vaccines, along with other aspects.

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Section: Uptake Of Omvs By Host Cellsmentioning

confidence: 99%

Section: Uptake Of Omvs By Host Cellsmentioning

confidence: 99%