Isolation of ursolic acid from apple peels by high speed counter-current chromatography

Frighetto, R. T. S.; Welendorf, Rodolfo Max; Nigro, Eduardo N.; Frighetto, Nélson; Siani, Antonio C.

doi:10.1016/j.foodchem.2007.06.003

Cited by 110 publications

(69 citation statements)

References 34 publications

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“…This is perhaps not surprising, as it has been reported that triterpenic compounds such as OA and UA are mainly distributed in the skins of fruits (Orbán et al, 2009;Frighetto et al, 2008), and these 5 kinds of dried fruit had their skins removed during processing (Table). The dried fruits without skin do not contain -or contain very little -OA and UA, which supports previous studies.…”

Section: Resultsmentioning

confidence: 77%

Oleanolic Acid and Ursolic Acid in Commercial Dried Fruits

Zhang¹,

Daimaru²,

Ohnishi³

et al. 2013

FSTR

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Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have preventive properties such as anti-tumor and anti-hepatitis activities. These triterpenes are known to exist in several medicinal plants and fruit skins. Dried fruits are usually eaten without removing the skin; thus, they may be good resources for oral intake of OA and UA. HPLC analysis of OA and UA contents in a variety of dried fruits showed that raisins contained higher levels of OA than the other fruits investigated, with green raisins containing the highest levels (79.0 mg/100 g). While raisins were found to contain only OA, dried cranberries, blueberries and cherries were shown to contain both OA and UA. The highest level of UA (65.9 mg/100 g) was detected in cranberries, which also exhibited relatively high OA levels (17.8 mg/100 g). Thus, raisins and dried cranberries can be used as rich sources of OA and UA.

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Section: Resultsmentioning

confidence: 77%

Oleanolic Acid and Ursolic Acid in Commercial Dried Fruits

Zhang¹,

Daimaru²,

Ohnishi³

et al. 2013

FSTR

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“…Several researchers have also evaluated the cytotoxic effects of ursolic acid and eichlerianic acid [18][19][20][21] isolated from other plant species in several cancer cell lines including MCF-7 breast cancer cells [22,23] and those results are some …”

Section: Discussionmentioning

confidence: 99%

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Samarakoon¹,

Ediriweera²,

Wijayabandara³

et al. 2018

Trop. J. Pharm Res

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and two-dimensional nuclear magnetic resonance (2D-NMR) and electron ionization-mass spectrometry (EI-MS) techniques. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the cytotoxic effects of the compounds on oestrogen receptor positive breast (MCF-7) and non-small cell lung (NCI-H-292) cancer cells. Results: The isolated compounds were identified as oleanolic acid (1), ursolic acid (2) and eichlerianic acid (3). Ursolic acid and eichlerianic acid showed strong cytotoxic effects {IC50-ursolic acid: 8.47 µg/mL (24 h, MCF-7), 7.78 µg/mL (24 h, NCI-H292) and eichlerianic acid: 8.86 µg/mL (24 h, MCF-7), 10.15 µg/mL (24 h, NCI-H292)} in MCF-7 and NCI-H292 cancer cells at 24, 48 and 72 h post-incubation periods. Conclusion: Hexane and chloroform extracts of the leaves of S. hydrophyllacea yielded three compounds namely oleanolic acid, eichlerianic acid and ursolic acid. Ursolic acid and eichlerianic acid have been isolated for the first time from the leaves of S. hydrophyllacea grown in Sri Lanka and demonstrate in-vitro cytotoxic effects in oestrogen receptor positive (MCF-7) and non-small lung cancer (NCI-H-292) cells.Keywords: Scyphiphora hydrophyllacea, eichlerianic acid, ursolic acid, oleanolic acid, This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest

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“…These results indicate that UA is able to sustain resistance exercise-induced mTORC1 activity. exercise; nutrition; supplement; muscle hypertrophy; intracellular signaling URSOLIC ACID (UA) is a natural pentacyclic triterpenoid carboxylic acid that is widely found in apple (a major compound of apple wax) and other fruits; it is known to exhibit a wide range of biological functions such as antioxidative, antimicrobial, anti-inflammatory, and anticancer activities (6,10). A recent study based on microarray analysis identified UA as an inhibitor of skeletal muscle atrophy and also, interestingly, revealed that skeletal muscle hypertrophy occurs by daily UA consumption (13).…”

Section: S6kmentioning

confidence: 99%