Isolation rearing of mice induces deficits in prepulse inhibition of the startle response

Varty, Geoffrey B.; Powell, Susan B.; Lehmann-Masten, Virginia; Buell, Mahalah R.; Geyer, Mark A.

doi:10.1016/j.bbr.2005.11.025

Cited by 62 publications

(54 citation statements)

References 14 publications

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“…Intrahippocampal injection in rats of 4-carboxy-3-hydroxyphenylglycine, 4-CPG, CPCCOEt, AIDA, and LY456236 evokes anxiolytic-like effects in the conflict drinking Vogel test (Chojnacka-Wójcik et al, 1997;Tatarczynska et al, 2001;Kłodziń ska et al, 2004;Varty et al, 2006). Furthermore, in rats AIDA increases the entries and time spent in open arms in the elevated plus-maze test, a widely used model based on the rodent's natural aversion to height and open space, but fails to exert anxiolytic-like activity in mice in the fourplate test (Kłodziń ska et al, 2004).…”

Section: Fear and Anxietymentioning

confidence: 99%

Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives

Ferraguti

Crepaldi

Nicoletti³

2008

Pharmacol Rev

193

205

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Almost 25 years after the first report that glutamate can activate receptors coupled to heterotrimeric G-proteins, tremendous progress has been made in the field of metabotropic glutamate receptors. Now, eight members of this family of glutamate receptors, encoded by eight different genes that share distinctive structural features have been identified. The first cloned receptor, the metabotropic glutamate ( mGlu) receptor mGlu1 has probably been the most extensively studied mGlu receptor, and in many respects it represents a prototypical subtype for this family of receptors. Its biochemical, anatomical, physiological, and pharmacological characteristics have been intensely investigated. Together with subtype 5, mGlu1 receptors constitute a subgroup of receptors that couple to phospholipase C and mobilize Ca(2+) from intracellular stores. Several alternatively spliced variants of mGlu1 receptors, which differ primarily in the length of their C-terminal domain and anatomical localization, have been reported. Use of a number of genetic approaches and the recent development of selective antagonists have provided a means for clarifying the role played by this receptor in a number of neuronal systems. In this article we discuss recent advancements in the pharmacology and concepts about the intracellular transduction and pathophysiological role of mGlu1 receptors and review earlier data in view of these novel findings. The impact that this new and better understanding of the specific role of these receptors may have on novel treatment strategies for a variety of neurological and psychiatric disorders is considered

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Section: Fear and Anxietymentioning

confidence: 99%

Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives

Ferraguti

Crepaldi

Nicoletti³

2008

Pharmacol Rev

193

205

View full text Add to dashboard Cite

show abstract

“…In particular, the finding of sensorimotor gating deficits in the paradigm of prepulse inhibition (PPI) is controversial, although it has been reported in both rats (Varty and Geyer 1998;Varty et al 2000;Weiss et al 2001b;Wilkinson et al 1994) and mice (Dai et al 2004(Dai et al , 2005Sakaue et al 2003;Varty et al 2006). This concerns most directly the face validity of the social isolation model, as PPI deficiency is a robust (although not specific) endophenotype of schizophrenia (Turetsky et al 2007).…”

Section: Introductionmentioning

confidence: 97%

The postweaning social isolation in C57BL/6 mice: preferential vulnerability in the male sex

et al. 2008

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“…In this procedure, rats or mice are housed in single cages from the time of weaning (about 21 days after birth) until adulthood (Bakshi & Geyer, 1999;Varty et al, 1999;Varty et al, 2006;Pietropaolo et al, 2008), and thereby deprived of social contact with their peers during (neuro)development (Einon & Morgan, 1977). In comparison to grouphoused controls, postweaning-isolated rodents exhibit a range of brain and behavioral changes, reminiscent to schizophrenia (Powell et al, 2003;Van den Buuse et al, 2003;Harte et al, 2007).…”

Section: Isolation Rearingmentioning

confidence: 99%

“…In comparison to grouphoused controls, postweaning-isolated rodents exhibit a range of brain and behavioral changes, reminiscent to schizophrenia (Powell et al, 2003;Van den Buuse et al, 2003;Harte et al, 2007). Several studies have reported PPI deficits in isolation-reared rats ) and mice (Varty et al, 2006;Pietropaolo et al, 2008), which could be reversed by pretreatment with typical and atypical antipsychotics (Varty & Higgins, 1995). However, subsequent studies have indicated that the effect of isolation rearing is strain dependent (Weiss et al, 2000), sensitive to housing conditions (Weiss et al, 1999), developmental timing (Wilkinson et al, 1994), and could be prevented by handling the isolated rats (Krebs- .…”

Section: Isolation Rearingmentioning

confidence: 99%