Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors

Aromatase Inhibitory Activity of Geranylated Coumarins, Mammeasins C and D, Isolated from the Flowers of <i>Mammea siamensis</i>

“…[1][2][3][4][5][6][7][8][9][10] Several coumarins, [1][2][3][4][5][6][7] xanthones, 8,9) triterpenoids, 10) and steroids 10) have been isolated from the flowers, 1,2,6,7,10) seeds, 3,9) twigs, 4,8) and bark 5) of this plant. In the course of our characterization studies on bioactive constituents in Thai natural medicine, 1,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] we reported that the methanol extract of the flowers of M. siamensis and its coumarin constituents showed inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 cells.…”

“…In the course of our characterization studies on bioactive constituents in Thai natural medicine, 1,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] we reported that the methanol extract of the flowers of M. siamensis and its coumarin constituents showed inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 cells. 1) Further studies revealed that the methanol extract inhibited enzymatic activity against aromatase.…”

Synthesis and Biological Activities of 5-Thio-α-GalCers

“…Comparing to the O-glycoside KRN7000, α-C-GalCer showed a stronger Th1 response in vivo, whereas the analogue α-S-GalCer did not activate the murine iNKT cells both in vitro and in vivo, but stimulated human iNKT cells in vitro. 36 Literature search revealed that very few examples have been found for carbohydrates having the ring sulfur structure in natural products, 37 one interesting report is the 5-thio-D-mannopyranose isolated from metabolites of the marine sponge Clathria pyramida (Lendenfled) with antimicrobial activity. 38 In a molecular modeling study, the carbon−sulfur bond is proposed to be more soft with regard to absorb the deviations of bond lengths and bond angles between ethers and thioethers, thereby minimizing structural changes of carbohydrate moieties.…”

Chemical Structures and Hepatoprotective Effects of Constituents from the Leaves of Salacia chinensis

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In the course of our characterization studies on bioactive constituents from Salacia species (Hippocrateaceae), [1][2][3][4][5][6] we have reported the isolation and absolute stereostructure elucidation of 13 megastigmane glycosides, 7 phenolic glycosides, and 11 triterpenes from the leaves of Salacia chinensis collected in Thailand together with 40 known constituents.

7-11)As a continuning study on the leaves of Salacia chinensis, the methanolic (MeOH) extract was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the MeOH extract, eight new glycosides, named foliachinenosides E, F, G, H, and I, and foliasalaciosides J, K, and L, were isolated together with 26 known constituents.

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“…In the course of our characterization studies on bioactive constituents from Salacia species (Hippocrateaceae), [1][2][3][4][5][6] we have reported the isolation and absolute stereostructure elucidation of 13 megastigmane glycosides, 7 phenolic glycosides, and 11 triterpenes from the leaves of Salacia chinensis collected in Thailand together with 40 known constituents.…”