Isoliquiritin promote angiogenesis by recruiting macrophages to improve the healing of zebrafish wounds

Liu, Yuyang; Wu, Jiaqi; Fan, Ruo-Yue; He, Zhiheng; Li, Chong-Yong; He, Ming-Fang

doi:10.1016/j.fsi.2020.02.071

Cited by 26 publications

(9 citation statements)

References 31 publications

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“…Another active component is isoliquiritin, an isoflavonoid isolated from Glycyrrhizae Radix et Rhizoma. According to Liu’s investigation, isoliquiritin at 100 or 200 μg/ml can accelerate the healing of zebrafish skin wound via promoting inflammation response and facilitating angiogenesis ( Liu et al, 2020 ).…”

Section: Botanical Drugs In Traditional Chinese Medicine With Wound H...mentioning

confidence: 99%

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

et al. 2022

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Chronic and unhealed wound is a serious public problem, which brings severe economic burdens and psychological pressure to patients. Various botanical drugs in traditional Chinese medicine have been used for the treatment of wounds since ancient time. Nowadays, multiple wound healing therapeutics derived from botanical drugs are commercially available worldwide. An increasing number of investigations have been conducted to elucidate the wound healing activities and the potential mechanisms of botanical drugs in recent years. The aim of this review is to summarize the botanical drugs in traditional Chinese medicine with wound healing properties and the underlying mechanisms of them, which can contribute to the research of wound healing and drug development. Taken together, five botanical drugs that have been developed into commercially available products, and 24 botanical drugs with excellent wound healing activities and several multiherbal preparations are reviewed in this article.

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Section: Botanical Drugs In Traditional Chinese Medicine With Wound H...mentioning

confidence: 99%

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

et al. 2022

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“…We failed to investigate the speci c mechanism of ISL in promoting angiogenesis in Choke II zone after ap transplantation. Previous studies have shown that the upregulation of VEGF/VEGFR2 and Ang/Tie signaling pathways by ISL may be associated with the angiogenic activity observed on zebra sh embryos [10]. Therefore, in the future, we will further study the speci c mechanism of ISL in promoting ap survival.…”

Section: Discussionmentioning

confidence: 91%

“…ISL has been reported to exert an additional proangiogenic effect on damaged angiogenesis in zebra sh embryos, which might be potentially used to treat disorders caused by insu cient angiogenesis [9]. Liu YY, et al [10] have investigated the effect and mechanism of ISL on wound healing activity in zebra sh, revealing that ISL can promote in ammatory response and angiogenesis, which plays a key role in promoting wound healing in zebra sh. Therefore, ISL is a promising candidate to promote wound healing.…”

Section: Introductionmentioning

confidence: 99%

Isoliquiritin Pre-Treatment Promotes Multi-Territory Perforator Flap Survival in Rats: An Experimental Study

Wang

Zhang

Wu³

et al. 2020

Preprint

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Background The present study was design to investigate the effect of isoliquiritin (ISL) pretreatment on multi-territory perforator flap survival and blood vessels of Choke II zone in rats.Methods A total of 80 adult Sprague-Dawley (SD) rats were randomly divided into ISL group and normal saline group, and subsequently and subjected to multi-territory perforator flap operations on the left flank. Afterwards, rats in ISL group were intraperitoneally injected with ISL, and rats from normal saline group were intraperitoneally injected with equal amount of normal saline. After seven days, the surviving flap area was calculated, the density of microvessels and (vascular endothelial growth factor,VEGF)were measured in Choke II zone. In addition, blood vessels of the flap were subjected to lead oxide-gelatin radiography.Results The flap survival area was significantly enhanced in rats from the ISL group compared with that from the saline group (P < 0.01). HE staining indicated significantly higher microvascular density in Choke II zone in the ISL group (P < 0.01). Immunohistochemistry and Western blot assays showed that the expression of VEGF in the ISL group was significantly higher than that in the control group (P < 0.01). Moreover, the vascular structure in Choke II zone of the flap was clearer, with more new blood vessels and more complete vascular structure in the potential zone from the ISL group, in comparison with those from the normal saline group.Conclusion ISL is beneficial to the multi-territory perforator flap survival in rats.

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“…The proinflammatory cytokines Il-1β and Tnf-α were controlled by macrophages in zebrafish [ 35 ]. Moreover, macrophages from zebrafish promote the healing of injury such as wounds [ 36 ]. Previous studies have indicated that the anti-inﬂammatory activity of diphlorethohydroxycarmalol against PM-stimulated responses in skin and immune cells [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Fucoxanthin-rich fraction from Sargassum fusiformis alleviates particulate matter-induced inflammation in vitro and in vivo

Dai

Jiang

et al. 2021

Toxicology Reports

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Particulate matter (PM) contributes to air pollution and primarily originates from unregulated industrial emissions and seasonal natural dust emissions. Fucoxanthin (Fx) is a marine natural pigment from brown macroalgae that has been shown to have various beneficial effects on health. However, the effects of Fx on PM-induced toxicities in cells and animals have not been assessed. In this study, we investigated the anti-inﬂammatory potential of the Fx-rich fraction (FxRF) of Sargassum fusiformis against PM-mediated inﬂammatory responses. The FxRF composition was analyzed by rapid-resolution liquid chromatography mass spectrometry. Fx and other main pigments were identified. FxRF attenuated the production of inﬂammatory components, including prostaglandin E2 (PGE 2 ), cyclooxygenase-2, interleukin (IL)-1β, and IL-6 from PM-exposed HaCaT keratinocytes. PM exposure also reduced the levels of nitric oxide (NO), tumor necrosis factor-α, inducible nitric oxide synthase (iNOS), and PGE 2 in PM-exposed RAW264.7 macrophages. Additionally, the culture medium from PM-exposed HaCaT cells induced upregulation of NO, iNOS, PGE 2 , and pro-inﬂammatory cytokines in RAW264.7 macrophages. FxRF also significantly decreased the expression levels of factors involved in inﬂammatory responses, such as NO, reactive oxygen species, and cell death, in PM-exposed zebrafish embryos. These results demonstrated the potential protective effects of FxRF against PM-induced inflammation both in vitro and in a zebrafish model.

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Isoliquiritin promote angiogenesis by recruiting macrophages to improve the healing of zebrafish wounds

Cited by 26 publications

References 31 publications

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

Isoliquiritin Pre-Treatment Promotes Multi-Territory Perforator Flap Survival in Rats: An Experimental Study

Fucoxanthin-rich fraction from Sargassum fusiformis alleviates particulate matter-induced inflammation in vitro and in vivo

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