Isomorphic phenomenon of Koebner: Facts and controversies

Camargo, Cláudia Medeiros; Brotas, Arles Martins; Ramos‐e‐Silva, Márcia; Carneiro, Sueli

doi:10.1016/j.clindermatol.2013.05.012

Cited by 76 publications

(51 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9 The Koebner phenomenon, fi rst described in 1872, refers to the appearance of psoriatic lesions after physical trauma to the surrounding tissue. 10 …”

Section: Management Of Patients With Psoriatic Arthritismentioning

confidence: 97%

Management of patients with psoriatic arthritis

Dewing¹

2015

The Nurse Practitioner

View full text Add to dashboard Cite

show abstract

“…9 The Koebner phenomenon, fi rst described in 1872, refers to the appearance of psoriatic lesions after physical trauma to the surrounding tissue. 10 …”

Section: Management Of Patients With Psoriatic Arthritismentioning

confidence: 97%

Management of patients with psoriatic arthritis

Dewing¹

2015

The Nurse Practitioner

View full text Add to dashboard Cite

show abstract

“…). There are likely to be many explanations including complex interactions between genetic background, gender or an accompanying photodermatosis such as PLE which may trigger psoriasis via Koebner‐related Wolf's isotopic phenomenon . With regard to genetics in PP, besides a reported potential link to HLA‐Cw*0602, more clues are coming from work in pityriasis rubra pilaris, a photosensitive condition with inconsistent response to UVB phototherapy .…”

Section: Genetics Of Photosensitive Psoriasismentioning

confidence: 99%

“…porphyria, chronic actinic dermatitis, systemic lupus erythematosus or polymorphic light eruption (PLE)] . Psoriasis induced by the so‐called Koebner response (or isomorphic phenomenon of Koebner) has been known for a long time . It refers to the appearance of isomorphic psoriatic lesions following a local trauma that may be caused, among other triggers, by (the sunburning effect of) UV radiation (Fig.…”

Section: Introductionmentioning

confidence: 99%

Desired response to phototherapy vs photoaggravation in psoriasis: what makes the difference?

Wolf

Weger

Patra

et al. 2016

Experimental Dermatology

View full text Add to dashboard Cite

Psoriasis commonly responds beneficially to UV radiation from natural sunlight or artificial sources. Therapeutic mechanisms include the proapoptotic and immunomodulating effects of UV, affecting many cells and involving a variety of pro-and anti-inflammatory cytokines, downregulating the Th17/IL-23 response with simultaneous induction of regulatory immune cells. However, exposure to UV radiation in a subset of psoriasis patients leads to exacerbation of the disease. We herein shed light on the predisposing factors of photosensitive psoriasis, including genetics (such as HLACw*0602 or CARD14), gender and coexisting photodermatoses such as polymorphic light eruption (PLE) in the context of potential molecular mechanisms behind therapeutic photoresponsiveness or photoaggravation. UV-induced damage/pathogenassociated molecular patterns, damage to self-coding RNA (signalling through Toll-like receptors), certain antimicrobial peptides and/or inflammasome activation may induce innate immunity, leading to psoriasis at the site of UV exposure when there is concomitant, predisposing resistance against UV-induced suppression of the adaptive immune response (like in PLE) that otherwise would act to reduce psoriasis. K E Y W O R D S

show abstract

“…Known exogenous triggers are skin aggression (35), infections (36-38), alcohol and tobacco (39-45), stress (43-46), drugs (lithium, beta-blockers, antimalarials, ACE-inhibitors, NSAIDs). (47-54) Endogenous triggers are hormonal changes (55,56) and allergies (57, 58).…”

Section: Introductionmentioning

confidence: 99%

An Epidemiological Study on Trigger Factors and Quality of Life in Psoriatic Patients

Xhaja¹,

Shkodrani²,

Frangaj³

et al. 2014

Mater Sociomed

View full text Add to dashboard Cite

Objective:to evaluate the role of stress, tobacco, drugs, infections, allergies, heredity, alcohol, hormones and skin aggressions as trigger factors and the impact on quality of life in a sample of psoriasis patients.Methods:a transversal study performed in 90 patients affected by psoriasis between January and November 2012 at the “Nene Tereza” University Hospital, Tirane, Albania, based on two scored questionnaires.Results:more than 70 % of patients reported that stressful events caused a flare- up of their psoriasis (p< 0.05). More than 60% of males and 20% of females were smokers (p< 0.05). About 20% of our patients were taking one or more of the medications listed in the questionnaire (p> 0.05). About 20% of patients reported having had recurrent infections (p<0,05). About 80% of males patients consumed alcohol (p<0,05). More than 40% reported a relative with psoriasis. Statistical comparison of the group that reported skin aggressions with the group that did not revealed a significant difference (p<0,05). Only a few of them reported to have allergies (p>0,05). About 36% of females reported that hormonal changes (puberty and menopause) exacerbated their psoriasis (p<0,05). More than 40% of patients reported that psoriasis seriously affects their quality of life.Conclusion:stress, tobacco, infections, heredity, alcohol, hormonal changes and skin aggressions were confirmed as trigger factors for psoriasis in the present sample. Allergies and the investigated drugs seemed not to have any influence in flare-ups. We found that psoriasis had a serious impact in the quality of life in over of 40% of the patients interviewed.

show abstract

Isomorphic phenomenon of Koebner: Facts and controversies

Cited by 76 publications

References 47 publications

Management of patients with psoriatic arthritis

Management of patients with psoriatic arthritis

Desired response to phototherapy vs photoaggravation in psoriasis: what makes the difference?

An Epidemiological Study on Trigger Factors and Quality of Life in Psoriatic Patients

Contact Info

Product

Resources

About