Isopenicins A–C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus <i>Penicillium</i> sp. sh18

Tang, Jianwei; Kong, Lingmei; Zu, Wen-Yu; Hu, Kun; Li, Xiaonian; Yan, Bing‐Chao; Wang, Weiguang; Sun, Han‐Dong; Li, Yan; Puno, Pema‐Tenzin

doi:10.1021/acs.orglett.8b04020

Cited by 54 publications

(33 citation statements)

References 17 publications

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“…2009 ), penicilliols ( Kimura et al. 2009 ), isopenicins ( Tang et al. 2019b ), andrastin A, antarone A, curvulic acid, gregatins, penicillifuranone A, viomellein, vioxanthin, and xanthomegnin.…”

Section: Resultsmentioning

confidence: 99%

Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species

Houbraken¹,

Kocsubé²,

Visagie³

et al. 2020

Studies in Mycology

402

458

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The Eurotiales is a relatively large order of Ascomycetes with members frequently having positive and negative impact on human activities. Species within this order gain attention from various research fields such as food, indoor and medical mycology and biotechnology. In this article we give an overview of families and genera present in the Eurotiales and introduce an updated subgeneric, sectional and series classification for Aspergillus and Penicillium . Finally, a comprehensive list of accepted species in the Eurotiales is given. The classification of the Eurotiales at family and genus level is traditionally based on phenotypic characters, and this classification has since been challenged using sequence-based approaches. Here, we re-evaluated the relationships between families and genera of the Eurotiales using a nine-gene sequence dataset. Based on this analysis, the new family Penicillaginaceae is introduced and four known families are accepted: Aspergillaceae , Elaphomycetaceae , Thermoascaceae and Trichocomaceae . The Eurotiales includes 28 genera: 15 genera are accommodated in the Aspergillaceae ( Aspergillago , Aspergillus , Evansstolkia , Hamigera , Leiothecium , Monascus , Penicilliopsis , Penicillium , Phialomyces , Pseudohamigera , Pseudopenicillium , Sclerocleista , Warcupiella , Xerochrysium and Xeromyces ), eight in the Trichocomaceae ( Acidotalaromyces , Ascospirella , Dendrosphaera , Rasamsonia , Sagenomella , Talaromyces , Thermomyces , Trichocoma ), two in the Thermoascaceae ( Paecilomyces , Thermoascus ) and one in the Penicillaginaceae ( Penicillago ). The classification of the Elaphomycetaceae was not part of this study, but according to literature two genera are present in this family ( Elaphomyces and Pseudotulostoma ). The use of an infrageneric classification system has a long tradition in Aspergillus and Penicillium . Most recent taxonomic studies focused on the sectional l...

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Section: Resultsmentioning

confidence: 99%

Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species

Houbraken¹,

Kocsubé²,

Visagie³

et al. 2020

Studies in Mycology

402

458

View full text Add to dashboard Cite

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“…Over the past several years, our groups have made great efforts to study the secondary metabolites from endophytic fungi inhabiting the Isodon species. As a result, isopenicin A, a potent inhibitor of Wnt signaling [ 18 ], as well as several antineoplastic compounds like phomopchalasins A and B [ 19 ] have been successfully obtained. In the present research, an endophytic fungus colonizing in the stems of Isodon xerophilus was discovered and identified as Arthrinium sp.…”

Section: Introductionmentioning

confidence: 99%

Arthrinins E–G, Three Botryane Sesquiterpenoids from the Plant Endophytic Fungus Arthrinium sp. HS66

Tang

et al. 2020

Nat. Prod. Bioprospect.

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Arthrinins E-G (1-3), three new sesquiterpenoids possessing non-isoprenoid botryane skeleton, were isolated from the fermentation of an endophytic fungus named Arthrinium sp. HS66 which colonized in the stems of Isodon xerophilus. Their structures were determined by extensive spectroscopic methods. Furthermore, the structure of 1 was unambiguously confirmed by X-ray diffraction, while those of 2 and 3 were verified through quantum chemical calculation of NMR data and ECD spectra.

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“…Fungal secondary metabolites have always been considered an important source for drug discovery due to their diverse chemical structures and bioactivities [1]. Among them, Penicillium are recognized as important producers of structurally unusual natural products, especially of terpenes with pharmaceutical potential as illustrated with chrysogenester, an anti-inflammatory meroterpenoid-type derivative [2], shearilicine, a cytotoxic indole-diterpenoid possessing a rare carbazole unit [3,4], and the penerpenes, unusual indole-terpenoids which have shown potent protein tyrosine phosphatase inhibitory activity [5].…”

Section: Introductionmentioning

confidence: 99%

“…The EtOAc extract of the fermentation broth showed significant activity against newly hatched larvae of Helicoverpa armigera Hubner. Chemical investigation of the fungus fermentation's organic extract resulted in the isolation of four new xanthene derivatives (1)(2)(3)(4), along with one known compound 5 (Figure 1). Herein, the isolation, structure elucidation, and insecticidal activity of these compounds are described.…”

Section: Introductionmentioning

confidence: 99%

Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246

et al. 2019

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Four new xanthene derivatives, penicixanthenes A–D (1–4), and one known compound 5 were isolated from a marine mangrove endophytic fungus Penicillium sp. JY246 that was obtained from the stem of Ceriops tagal. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher’s method, and calculated electronic circular dichroism data. All of the isolated compounds were examined for insecticidal activity. Compounds 2 and 3 showed growth inhibition activity against newly hatched larvae of Helicoverpa armigera Hubner with the IC50 values 100 and 200 μg/mL, respectively, and compounds 1, 3, and 4 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with LC50 values of 38.5 (±1.16), 11.6 (±0.58), and 20.5 (±1) μg/mL, respectively. The four xanthene derivatives have the potential to be developed as new biopesticides.

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Isopenicins A–C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18

Cited by 54 publications

References 17 publications

Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species

Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species

Arthrinins E–G, Three Botryane Sesquiterpenoids from the Plant Endophytic Fungus Arthrinium sp. HS66

Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246

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