Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities

Strobel, Gary A.; Ford, Eugene; Worapong, Jeerepun; Harper, James K.; Arif, Atta M.; Grant, David M.; Fung, P. C. W.; Chau, Raymond Ming Wah

doi:10.1016/s0031-9422(02)00062-6

Cited by 311 publications

(157 citation statements)

References 14 publications

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“…In 1993, a novel anticancer compound taxol was produced from fungus Taxomyces andreanae, isolated from the yew Taxus brevifolia (Huang et al, 2008). In the same way anti-inflammatory compounds pestacin and isopestacin were isolated from Pestalotiopsis microspora of the plant Terminalia morobensis (Strobel et al, 2002). An antimicrobial compound clavatol was obtained from endophytic fungi Aspergillus clavatonanicus isolated from Torreya mairei .…”

Section: Bioactive Compounds From Endophytic Fungimentioning

confidence: 99%

Biosynthesis of silver nanoparticles by endophytic fungi: Its mechanism, characterization techniques and antimicrobial potential

Sandhu¹,

Shukla²,

Shukla³

2017

Afr. J. Biotechnol.

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Nanotechnology has rapidly developed as an important field of modern research, generating most promising applications in electronics and medicine. It involves different approaches for the synthesis and application of nanoparticles having dimension smaller than 100 nm. Nanoparticles are the fundamental building blocks for preparing many nanostructured materials and devices. Therefore, there is an enormous interest in developing safe, cost effective and ecofriendly techniques for synthesis of nanoparticles. Biological synthesis has emerged as an attractive alternative to overcome the side effects accompanied with physical and chemical methods of synthesis. This led to the development of new branch of nanotechnology called "green nanotechnology" or "nanobiotechnology" which combines biological principles with physical and chemical procedures to generate eco-friendly nanosized particles with specific functions. Various biological entities could be employed for the biosynthesis of nanoparticles including plant, algae, fungi, yeast, bacteria and viruses. Recently, much attention has been given on exploring fungi as potent biofactories for synthesis of silver nanoparticles since they possess numerous bioactive properties which find variety of applications in the field of biomedicine. Its use in the form of effective antimicrobial agent and disinfectant is known since time immemorial. The present chapter emphasize on the richness of endophytic fungal diversity and their role in biosynthesis of silver nanoparticles. It gives detailed overview about the mechanism of synthesis, characterization techniques involved in analysis of silver nanoparticles and biomedical application of silver nanoparticles with special reference to their antimicrobial potential.

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Section: Bioactive Compounds From Endophytic Fungimentioning

confidence: 99%

Biosynthesis of silver nanoparticles by endophytic fungi: Its mechanism, characterization techniques and antimicrobial potential

Sandhu¹,

Shukla²,

Shukla³

2017

Afr. J. Biotechnol.

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“…These new potent antioxidants were obtained from Pestalotiopsis microspora, an endophyte of Terminalia morobensis inhabiting the Sepik River drainage of Papua New Guinea (Strobel et al 2002;Harper et al 2003).…”

Section: Endophytic Natural Products As Drugs and Novel Drug Leadsmentioning

confidence: 99%

Endophytes: exploiting biodiversity for the improvement of natural product-based drug discovery

Staniek

Woerdenbag

Kayser

2008

Journal of Plant Interactions

132

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Endophytes, microorganisms that colonize internal tissues of all plant species, create a huge biodiversity with yet unknown novel natural products, presumed to push forward the frontiers of drug discovery. Next to the clinically acknowledged antineoplastic agent, paclitaxel, endophyte research has yielded potential drug lead compounds with antibacterial, antiviral, antioxidant, insulin mimetic, anti-neurodegenerative and immunosuppressant properties. Furthermore, while being implicated in livestock neurotoxicosis, some endophyte-produced alkaloids have been shown to display insecticidal activity. The endophyte-host relationship is postulated to be a 'balanced antagonism'. Moreover, the plausibility of horizontal gene transfer (HGT) hypothesis is taken into account. Knowledge of the genetic background of endophytic natural product biosynthesis is discussed on the basis of loline alkaloids, ergopeptines, lolitrems and maytansinoids. The current dynamic progress in genomics will contribute to a better understanding of endophytic microbes and to further exploiting them as a source of pharmaceutically relevant compounds.

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“…Various degenerative human diseases including Alzheimer's disease, diabetes mellitus, neurodegenerative disorders, Parkinson's disease, inflammation, atherosclerosis, cancer, and aging are associated with uncontrolled generation of free radicals [9]. Several medicinal plants are known for their antioxidant capacity since antiquity [10]. The genus Terminalia (Combretaceae) comprises nearly 200 species distributed around the world.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, Antioxidant, Chemical Constituents, and Cytotoxicity Evaluation of Terminalia Arjuna (Roxb. Ex Dc.) Wight and Arn

Khatri¹,

Phougat²,

Dangi³

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this study is to evaluate the in vitro antibacterial and antioxidant prospective of Terminalia arjuna (leaves). The most active extracts were examined for their chemical composition and cytotoxicity.Methods: The antibacterial activity of five different extracts were examined against 8 bacterial strains (5 Gram-positive and 3 Gram-negative) using resazurin-based microtiter dilution assay (RMDA) and disk-diffusion assay. The antioxidant potential of five extracts was demonstrated using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay and superoxide radical scavenging assay. Chemical composition and cytotoxicity were assessed using gas chromatography-mass spectrometry (GC-MS) and hemolytic assay, respectively.Results: According to RMDA, the acetone extract (AE) exhibited highest antibacterial activity. The AE showed highest activity against Salmonella enterica ser. typhi and Bacillus cereus with minimum inhibitory concentration, i.e., 195.31 μg/ml. In DPPH assay, AE showed the highest radical scavenging activity with inhibition concentration 50 23.09 μg/ml. In GC-MS analysis, the principal compound in AE was celidoniol (8.72 %). According to the results of hemolytic assay, the AE showed non-toxic behavior upto 500 μg/ml. Conclusion:The present investigation represents T. arjuna as an incredible herb. The AE was found to possess promising antibacterial and antioxidant properties.

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Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities

Cited by 311 publications

References 14 publications

Biosynthesis of silver nanoparticles by endophytic fungi: Its mechanism, characterization techniques and antimicrobial potential

Biosynthesis of silver nanoparticles by endophytic fungi: Its mechanism, characterization techniques and antimicrobial potential

Endophytes: exploiting biodiversity for the improvement of natural product-based drug discovery

Antibacterial, Antioxidant, Chemical Constituents, and Cytotoxicity Evaluation of Terminalia Arjuna (Roxb. Ex Dc.) Wight and Arn

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