Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway

Shui, Liyan; Wang, Weina; Xie, Mingjie; Ye, Bingjue; Li, Xian; Liu, Yanning; Zheng, Min

doi:10.18632/aging.202237

Cited by 58 publications

(33 citation statements)

References 57 publications

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“…Notably, it was demonstrated that Emodin, a Chinese herb, induced apoptosis in colon cancer cells through stimulation of autophagy [ 113 ]. The same observation was noted in hepatocellular carcinoma cells (HepG2 and Huh7) where autophagy inhibition via 3-methyladenin inhibited apoptosis was caused by isoquercitrin (ISO) exposure [ 114 ]. Collectively, these findings reflect a potential role of autophagy in regulation of apoptosis during tumor progression.…”

Section: Autophagy and Cancersupporting

confidence: 57%

Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma

El-Aziz

Leck

Jansson

et al. 2021

Cancers

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Autophagy is a cellular catabolic process, which is characterized by degradation of damaged proteins and organelles needed to supply the cell with essential nutrients. At basal levels, autophagy is important to maintain cellular homeostasis and development. It is also a stress responsive process that allows the cells to survive when subjected to stressful conditions such as nutrient deprivation. Autophagy has been implicated in many pathologies including cancer. It is well established that autophagy plays a dual role in different cancer types. There is emerging role of autophagy in oral squamous cell carcinoma (OSCC) development and progression. This review will focus on the role played by autophagy in relation to different aspects of cancer progression and discuss recent studies exploring the role of autophagy in OSCC. It will further discuss potential therapeutic approaches to target autophagy in OSCC.

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Section: Autophagy and Cancersupporting

confidence: 57%

Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma

El-Aziz

Leck

Jansson

et al. 2021

Cancers

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“…For instance, isoquercitrin promotes autophagy and subsequently activates mitochondrial‐dependent pathway leading to increase in the level of active caspase‐3 in liver cancer. 13 Mitochondrial pathway of apoptosis induced by hyperoside in colorectal cancer is triggered by p53. 14 Apigenin suppress cell cycle progression through G2/M arrest and promotes p53‐dependent mitochondrial pathway of apoptosis in gastrointestinal cancers.…”

Section: Introductionmentioning

confidence: 99%

Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Szoka

Nazaruk

Stocki

et al. 2021

J Cellular Molecular Medi

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Numerous studies provide evidence for the potential beneficial effect of flavonoids in cancer chemoprevention and inducing cancer cell death. 1,2 Flavonoids are low molecular weight, secondary plant metabolites characterized by a benzoγ-pyrone core. This broad class of phenolics contains over 4000 compounds. 3 Due to their wide distribution in the leaves, flowers, fruits, bark and seeds of plants, flavonoids are part of human diet and herbal medicine. Flavonoids occur in plant cells primarily as glycosides and polymers that need to be degraded before absorption. 4 Hydrolysis of flavonoid glycosides is catalysed by small intestine hydrolases and human intestinal microflora. Absorbed aglycones are metabolized by glucuronidation, sulfation and O-methylation in enterocytes, or transported with subsequent conjugation in the liver. Consequently, orally administered flavonoids reach the highest concentration and thus exert the most potent effect in the digestive tract and liver. Downy birch (Betula pubescens Ehrh.) and silver birch (Betula pendula Roth) are deciduous trees characterized by their silver-white bark.Downy birch commonly grows in Europe and northern Asia, particularly in damp soils, while silver birch prefers less moist soils. 5 Dried fresh leaves of both birch species are used in Polish traditional medicine as a diuretic. 6 The major constituents of the leaves that probably cause the diuretic effect are flavonoids, hyperoside and other

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“…Also, it can inhibit apoptosis by activating the PI3K/Akt signaling pathway to increase Bcl-2 protein expression and decrease Bax protein expression ( 161 ). In addition, quercetin activates autophagy through the AMPK signaling pathway ( 162 ).…”

Section: Quercetin Regulates the Mtor Signaling Pathway To Improve Scimentioning

confidence: 99%

Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway

Wang

Botchway

et al. 2022

Front. Neurol.

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The pathogenesis of spinal cord injury (SCI) is complex. At present, there is no effective treatment for SCI, with most current interventions focused on improving the symptoms. Inflammation, apoptosis, autophagy, and oxidative stress caused by secondary SCI may instigate serious consequences in the event of SCI. The mammalian target of rapamycin (mTOR), as a key signaling molecule, participates in the regulation of inflammation, apoptosis, and autophagy in several processes associated with SCI. Quercetin can reduce the loss of myelin sheath, enhance the ability of antioxidant stress, and promote axonal regeneration. Moreover, quercetin is also a significant player in regulating the mTOR signaling pathway that improves pathological alterations following neuronal injury. Herein, we review the therapeutic effects of quercetin in SCI through its modulation of the mTOR signaling pathway and elaborate on how it can be a potential interventional agent for SCI.

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Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway

Cited by 58 publications

References 57 publications

Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma

Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma

Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway

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