In order to obtain the maximum relative density of γ-Ti-46.6Al-1.4Mn-2Mo alloy, the effects of the sintering temperature, heating preservation time and compacting force prepared by hot pressing were studied using Back Propagation (BP) Neural Network. The process parameters were optimized by Genetic Algorithm (GA) contributed by the use of Matlab. The results show that the optimum preparation process for Ti-46.6Al-1.4Mn-2Mo alloy are hot-pressing sintering temperature of 1374oC, heating preservation time of 291 min, compacting force of 37Mpa. The relative density of Ti-46.6Al-1.4Mn-2Mo alloy prepared under the condition is 96.11% (predicted value is 96.87%) with the relative error was only 0.78%. The microstructures of Ti-46.6Al-1.4Mn-2Mo alloy are studied by X-ray, optical microscope and SEM.