Isotope ratio mass spectrometry as a tool for source inference in forensic science: A critical review

Gentile, Natacha; Siegwolf, Rolf; Esseiva, Pierre; Doyle, Seán; Zollinger, Kurt; Delémont, Olivier

doi:10.1016/j.forsciint.2015.03.031

Cited by 65 publications

(27 citation statements)

References 189 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[104] However,owing to the KIE, subtle variations in the isotopic composition, also known as isotopic fractionation, [105] can result in the accumulation of heavier isotopes in the residual substrate fraction of biological, chemical, or physical degradation processes.A s ar esult, the relative abundance measured in different materials can provide important environmental information on their origin and history. [106] Accordingly,a nalysis of naturally abundant stable isotope ratios,f or example,b y IRMS (isotope ratio MS), [107] IRIR (isotope ratio IR), [108] or ICP-MS (inductively coupled plasma MS), [109] has been recognized as ap owerful tool in forensic science,g eochemistry,p aleoclimatology,e cology,a nd physiology. [110] Applications are numerous and include,f or example,the origin and/ or counterfeit tracing of food, [111] water, [112] pollutants, [113] or pharmaceuticals, [114] and the isotopic characterization of drugs [115] and explosives, [116] as well as the fate assessment of contaminants in soils and aquifers.…”

Section: Isotope Effects In Non-covalent Interactionsmentioning

confidence: 99%

Deuterium‐ and Tritium‐Labelled Compounds: Applications in the Life Sciences

Atzrodt¹,

Derdau²,

et al. 2018

View full text Add to dashboard Cite

Hydrogen isotopes are unique tools for identifying and understanding biological and chemical processes. Hydrogen isotope labelling allows for the traceless and direct incorporation of an additional mass or radioactive tag into an organic molecule with almost no changes in its chemical structure, physical properties, or biological activity. Using deuterium-labelled isotopologues to study the unique mass-spectrometric patterns generated from mixtures of biologically relevant molecules drastically simplifies analysis. Such methods are now providing unprecedented levels of insight in a wide and continuously growing range of applications in the life sciences and beyond. Tritium ( H), in particular, has seen an increase in utilization, especially in pharmaceutical drug discovery. The efforts and costs associated with the synthesis of labelled compounds are more than compensated for by the enhanced molecular sensitivity during analysis and the high reliability of the data obtained. In this Review, advances in the application of hydrogen isotopes in the life sciences are described.

show abstract

Section: Isotope Effects In Non-covalent Interactionsmentioning

confidence: 99%

Deuterium‐ and Tritium‐Labelled Compounds: Applications in the Life Sciences

Atzrodt¹,

Derdau²,

et al. 2018

View full text Add to dashboard Cite

show abstract

“…[104] Allerdings kçnnen aufgrund des KIE geringste Schwankungen in der Isotopenzusammensetzung,a uch als Isotopenfraktionierung [105] bekannt, zur Anreicherung von schwereren Isotopen in Substratrückständen biologischer, chemischer oder physikalischer Abbauprozesse führen. [106] Entsprechend hat sich die Analyse der natürlichen Isotopenverhältnisse,z.B.durch IRMS (isotope ratio MS), [107] IRIR (isotope ratio IR) [108] oder ICP-MS (MS mit induktiv gekoppeltem Plasma), [109] als eine wirkungsvolle Methode in der Forensik, der Geochemie,der Paläoklimatologie,der Ökologie und der Physiologie etabliert. [106] Entsprechend hat sich die Analyse der natürlichen Isotopenverhältnisse,z.B.durch IRMS (isotope ratio MS), [107] IRIR (isotope ratio IR) [108] oder ICP-MS (MS mit induktiv gekoppeltem Plasma), [109] als eine wirkungsvolle Methode in der Forensik, der Geochemie,der Paläoklimatologie,der Ökologie und der Physiologie etabliert.…”

Section: Isotopeneffekte Bei Nicht-kovalenten Wechselwirkungenunclassified

“…Daraus resultiert, dass die relative Isotopenhäufigkeit, die in einem Material gemessen wird, wichtige Hinweise über dessen Herkunft und Geschichte liefern kann. [106] Entsprechend hat sich die Analyse der natürlichen Isotopenverhältnisse,z.B.durch IRMS (isotope ratio MS), [107] IRIR (isotope ratio IR) [108] oder ICP-MS (MS mit induktiv gekoppeltem Plasma), [109] als eine wirkungsvolle Methode in der Forensik, der Geochemie,der Paläoklimatologie,der Ökologie und der Physiologie etabliert. [110] Die Anwendungsmçglichkeiten sind zahlreich und umfassen z.…”

Section: Isotopeneffekte Bei Nicht-kovalenten Wechselwirkungenunclassified

Deuterium‐ und tritiummarkierte Verbindungen: Anwendungen in den modernen Biowissenschaften

Atzrodt¹,

Derdau²,

Kerr

et al. 2018

Angewandte Chemie

108

View full text Add to dashboard Cite

Wasserstoffisotope sind einzigartige Werkzeuge zur Identifizierung und Erforschung biologischer oder chemischer Vorgänge. Wasserstoffisotopenmarkierungen erlauben den spurlosen und direkten Einbau einer zusätzlichen Masseneinheit oder eines radioaktiven Markers in ein organisches Molekül, und dies praktisch ohne Änderungen der chemischen Struktur, der physikalischen Eigenschaften oder der biologischen Aktivität. Die Verwendung von deuteriummarkierten Isotopologen zur Untersuchung der spezifischen massenspektrometrischen (MS) Muster, die von Gemischen biologisch relevanter Moleküle hervorgerufen werden, ermöglicht eine drastische Vereinfachung der Analyse. Solche Methoden ermöglichen nun tiefe Einblicke in einen großen, kontinuierlich anwachsenden Bereich von Anwendungen in den Biowissenschaften und darüber hinaus. Speziell Tritium (3H) wird zunehmend eingesetzt, insbesondere in der pharmazeutischen Wirkstoffsuche. Aufwand und Kosten der Synthese markierter Verbindungen werden durch die hohe Empfindlichkeit der Analyse und hohe Zuverlässigkeit der erhaltenen Daten mehr als ausgeglichen. In diesem Aufsatz werden Fortschritte bei der Verwendung von Wasserstoffisotopen in den Biowissenschaften beschrieben.

show abstract

“…As phenacetin is thought to originate from pharmaceutical production sites, profiling methods [10] classically used by forensic scientists to map trafficking networks, such as synthetic impurities or residual solvents, can hardly be applied. Isotope ratio mass spectrometry (IRMS) [11] therefore appears as a promising alternative to trace, and possibly source our molecule of interest.…”

Section: Introductionmentioning

confidence: 99%

IRMS to study a common cocaine cutting agent: phenacetin

Ladroue

Dujourdy

Besacier

et al. 2017

Drug Testing and Analysis

View full text Add to dashboard Cite

Phenacetin is a pharmaceutical closely related to acetaminophen that has been banned in France for a long time due to its nephritic and carcinogenic adverse effects. It frequently appears in cocaine seizures as a cutting agent. Following both sanitary and intelligence motivations, this molecule was chosen for this study, and stable isotopes seemed to be the most appropriate tool. A total of 228 seized samples were collected over a 6-year period, and 8 standards of known origin were purchased. They were submitted to gas chromatography (GC) or elemental analysis - isotope ratio mass spectrometry (EA-IRMS) measurements, depending on their complexity. Stable isotope ratios of carbon, hydrogen, and nitrogen for a part of the sample set, were acquired. The isotopic values of phenacetin standards acquired from various providers located worldwide are quite spread, which indicates that stable isotopes could be used to discriminate manufacturers. However, the measured values of most of the seized samples are concentrated in a narrow range, tending to demonstrate that phenacetin is smuggled from a single source or similar ones. Consequently, stable isotopes could only be used to exclude that several samples come from a common source. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Isotope ratio mass spectrometry as a tool for source inference in forensic science: A critical review

Cited by 65 publications

References 189 publications

Deuterium‐ and Tritium‐Labelled Compounds: Applications in the Life Sciences

Deuterium‐ and Tritium‐Labelled Compounds: Applications in the Life Sciences

Deuterium‐ und tritiummarkierte Verbindungen: Anwendungen in den modernen Biowissenschaften

IRMS to study a common cocaine cutting agent: phenacetin

Contact Info

Product

Resources

About