Isotretinoin improves the appearance of photodamaged skin: Results of a 36-week, multicenter, double-blind, placebo-controlled trial

Treatment of photoaged skin with a cream containing 0.05% isotretinoin and sunscreens

“…Tretinoin was the first of the topical retinoids that was shown to be able to reduce skin photoaging (2,5). Subsequently, isotretinoin (9,15,16), tazarotene (17,18) and adapalene have been reported to improve photoaged skin. The present study confirms and expands the observations on the effects of topical isotretinoin.…”

Reversal of Skin Aging with Topical Retinoids

“…Three groups have performed large (n = 776, n = 326, and n = 800) double-blind, vehicle-controlled, randomized trials using 0.1% cream for 9 months. [47][48][49] All demonstrated statistically significant clinical improvement in wrinkling pigmentation, sallowness, and texture compared with controls starting at 12 weeks. However, no significant changes were found in the dermis in terms of elastosis reduction or fibroblast density.…”

Vitamins and photoaging: Do scientific data support their use?

“…40,41 Three subsequent studies found that a once-daily application of 0.1% isotretinoin (an isomer of retinoic acid) cream for 36 weeks was effective in reducing fine wrinkles; in two of these studies a 0.05% cream had similar efficacy. [42][43][44] Three large-scale clinical trials investigating the efficacy of topical 0.1% tazarotene cream have uniformly supported its effectiveness in minimizing fine wrinkles and mottled hyperpigmentation. [45][46][47] One of these trials compared 4 different concentrations (0.1%, 0.05%, 0.025%, 0.01%) of tazarotene cream with 0.05% tretinoin cream.…”