Isovolumic relaxation period as an index of left ventricular relaxation under different afterload conditions. Comparison with the time constant of left ventricular pressure decay in the dog.

Ochi, Hiroshi; Ikuma, Isao; Toda, H; Shimada, Tetsuya; Morioka, S; Moriyama, Kiyoshi

doi:10.1253/jcj.53.1521

Cited by 3 publications

(1 citation statement)

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“…Because subjects in this study did not have valvular disease and left ventricular dysfunction, we thought that the effect of left atrial pressure on IRP was slight. In a previous publication we reported that IRP reflects left ventricular relaxation under various afterload condi tions in anesthetized open-chest dogs [27]. We believed that in the present study the change of IRP partly reflects a change in the left ventricular relaxation, although the influence of a change in aortic dicrotic notch pressure cannot be ignored.…”

Section: Effects Of Increased Agementioning

confidence: 54%

Effect of a Decrease in Aortic Compliance on the Isovolumic Relaxation Period of the Left Ventricle in Man

Ochi¹,

Shimada²,

Ikuma³

et al. 1991

Am J Noninvas Cardiol

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A decrease in aortic compliance can modify the loading sequence to the left ventricular ejection in the elderly. To determine whether a decreased aortic compliance influences the left ventricular relaxation in man, 83 healthy volunteers, aged 34-87 years, were studied. The left ventricular relaxation was characterized by the isovolumic relaxation period (IRP) of the left ventricle. The aortic compliance was characterized by the aortic pulse wave velocity (AoPWV). The loading sequence to left ventricular ejection was classified into three groups by carotid pulse contour; type A, dominant tidal wave; type B, percussion wave almost equal to the tidal wave; type C, dominant percussion wave. IRP and AoPWV increased with age. The mean arterial pressure was unrelated to age. IRP was significantly related to AoPWV and mean arterial pressures. Multiple regression analysis, correlating IRP with AoPWV and mean arterial pressure, demonstrated that only AoPWV was an independent factor to explain IRP. IRP was longer in type A than in type C, and AoPWV was faster in type A than in type C volunteers. The prominent tidal wave in type A may reflect a more rapid transmission of arterial wave reflection which can result in a change of the loading sequence to the left ventricular ejection. These results reveal that a decrease in aortic compliance with aging can affect left ventricular relaxation through the change of the loading sequence in man.

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Section: Effects Of Increased Agementioning

confidence: 54%