Israeli Spotted Fever Rickettsia (<i>Rickettsia conorii</i> Complex) Associated with Human Disease in Portugal

Bacellar, Fátima; Béati, Lorenza; França, Ana; Poças, José; Regnery, Russell L.; Filipe, Armindo R.

doi:10.3201/eid0506.990620

Cited by 51 publications

(45 citation statements)

References 6 publications

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“…In 1999, the disease fatality rate was 2.8%. 7,10 The malign form of the Mediterranean spotted fever has increased in Portugal in the last three years and has been identified in some hospital services. Several bacteria have been isolated and it was possible to identify a strain of the R. conorii complex, previously found only in Israel.…”

Section: Occurrence and Distribution Of Rickettsial Diseases In Brazimentioning

confidence: 99%

“…Multiorgan failure is a common finding. 1,7,37 The Center for Vector and Infectious Diseases Studies of Dr. Ricardo Jorge National Health Institute is the national reference rickettsial laboratory in Portugal. Over the last eight years (1995-2002) around 4,868 tests for R. conorii were performed using indirect immunofluorescence, of which 10% were positive.…”

Section: Occurrence and Distribution Of Rickettsial Diseases In Brazimentioning

confidence: 99%

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Riquetsioses no Brasil e Portugal: ocorrência, distribuição e diagnóstico

et al. 2005

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The present study is an update review on the occurrence and diagnosis of rickettsial diseases in Brazil and Portugal, aiming at promoting their epidemiological surveillance in both countries. A literature review was carried out and unpublished data of laboratories and surveillance systems were presented. The results described the occurrence of rickettsial diseases and infections in Brazil and Portugal, including other new and still poorly understood rickettsial infections. Current diagnostic methods were discussed. As in many other countries, rickettsial diseases and infections seem to be an emerging public health problem. Treated as a minor problem for many decades, the interest in these infections has increased in both countries but further studies are needed to establish their role as a public health problem.

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Section: Occurrence and Distribution Of Rickettsial Diseases In Brazimentioning

confidence: 99%

Section: Occurrence and Distribution Of Rickettsial Diseases In Brazimentioning

confidence: 99%

Riquetsioses no Brasil e Portugal: ocorrência, distribuição e diagnóstico

et al. 2005

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“…MSF is caused by two strains: R. conorii Malish, which is endemic in the Mediterranean area, and Israeli tick typhus (ITT). The latter strain was believed to be restricted to Israel, but was isolated from a patient in Portugal for the first time in 1997 (Bacellar et al, 1999). In Portugal, MSF is endemic and is an obligatory reported disease, with an incidence rate of 9 .…”

Section: Introductionmentioning

confidence: 99%

Characterization of a tandem repeat polymorphism in Rickettsia strains

Vitorino

Sousa

Bacellar

et al. 2005

Journal of Medical Microbiology

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Mediterranean spotted fever (MSF) is a tick-borne rickettsiosis caused by 'Rickettsia conorii complex' strains. In Portugal, R. conorii and Israeli tick typhus (ITT) are the aetiological agents of this disease. A novel 65 bp tandem repeat was identified by the analysis of the R. conorii Malish 7 whole genome sequence with an appropriate algorithm for searching for repeated sequences. The variable number tandem repeat (VNTR) was named VNTR Rc-65 and this locus was amplified by PCR and sequenced in order to characterize the repeat diversity within different rickettsial strains including Portuguese strains isolated from clinical and vector samples. The VNTR Rc-65 has seven alleles within the rickettsial strains studied and a diversity index value of 0 . 71, meaning that this locus has a great discriminatory capacity and therefore can be used for identification of closely related strains. PCR amplification of the Rc-65 locus can be used to differentiate between the Portuguese R. conorii Malish-like and Israeli tick typhus strains, enabling a more accurate and rapid identification of these rickettsial isolates.

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“…4 As manifestações clínicas e laboratoriais são resultado de uma vasculite sistémica de pequenos e médios vasos 5 consequente ao angiotropismo próprio do agente. Classicamente a doença caracteriza-se pela tríade febre alta, escara de inoculação e exantema maculopapular.…”

Section: 2unclassified

“…4 Nos últimos 20 anos têm surgido, por toda a Europa, novas espécies de Rickettsia, algumas das quais já descritas em Portugal. 10,13,14 Questiona-se se estas estirpes emergentes serão mais virulentas.…”

Section: 2unclassified

Febre Escaro-Nodular: Revisão Retrospetiva de Casos Hospitalizados e Fatores Preditores de Doença Severa

2015

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Results:We reviewed 71 cases of Mediterranean spotted fever. The mean age was 63.3 ± 16.7 years and 52.1% were male. The eschar was observed in 62.0%. Fever and rash were the most common clinical findings. Forty five percent of patients developed complications and 22.5% were admitted to intermediate and/or intensive care units. Apyrexia, dyspnea, renal failure and elevated lactic dehydrogenase levels at admission were predictors of severe disease development (p < 0.034). Alcoholism was related with prolonged hospitalization (p = 0.020). Absence of fever (p = 0.019) and elevated serum creatinine levels (p = 0.028) were identified as independent factors associated with severe outcome. The mortality rate was 2.8%. Discussion: Although Mediterranean spotted fever is usually assumed to be benign, severe cases are emerging. Conclusion: Early identification of the infection and continuous patient surveillance are crucial, particularly in those with greater risk of developing severe or fatal disease.

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Israeli Spotted Fever Rickettsia (Rickettsia conorii Complex) Associated with Human Disease in Portugal

Cited by 51 publications

References 6 publications

Riquetsioses no Brasil e Portugal: ocorrência, distribuição e diagnóstico

Riquetsioses no Brasil e Portugal: ocorrência, distribuição e diagnóstico

Characterization of a tandem repeat polymorphism in Rickettsia strains

Febre Escaro-Nodular: Revisão Retrospetiva de Casos Hospitalizados e Fatores Preditores de Doença Severa

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