Issue Editors’ Notes

Weichold, Karina; Giannotta, Fabrizia

doi:10.1002/yd.20081

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Complementary in vivo experiments knocking out the potential phosphorylation sites in the WOX5 protein may drive phenotypic effects in transformed wox5 mutant plants aiding in the characterization of the functional significance of these phosphorylated residues. However, although WOX5 is deemed to be a key player in root stem cell regulation, it would be presumptuous to ignore the parallel inputs derived from other transcription factors [73] or potential regulation influenced by the combinatorial activity of different transcription factors [74]. …”

Section: Discussionmentioning

confidence: 99%

Evidence for Intermolecular Interactions between the Intracellular Domains of the Arabidopsis Receptor-Like Kinase ACR4, Its Homologs and the Wox5 Transcription Factor

Meyer

Shah

Zhang³

et al. 2015

PLoS ONE

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Arabidopsis CRINKLY4 (ACR4) is a receptor-like kinase (RLK) involved in the global development of the plant. The Arabidopsis genome encodes four homologs of ACR4 that contain sequence similarity and analogous architectural elements to ACR4, termed Arabidopsis CRINKLY4 Related (AtCRRs) proteins. Additionally, a signaling module has been previously proposed including a postulated peptide ligand, CLE40, the ACR4 RLK, and the WOX5 transcription factor that engage in a possible feedback mechanism controlling stem cell differentiation. However, little biochemical evidence is available to ascertain the molecular aspects of receptor heterodimerization and the role of phosphorylation in these interactions. Therefore, we have undertaken an investigation of the in vitro interactions between the intracellular domains (ICD) of ACR4, the CRRs and WOX5. We demonstrate that interaction can occur between ACR4 and all four CRRs in the unphosphorylated state. However, phosphorylation dependency is observed for the interaction between ACR4 and CRR3. Furthermore, sequence analysis of the ACR4 gene family has revealed a conserved ‘KDSAF’ motif that may be involved in protein-protein interactions among the receptor family. We demonstrate that peptides harboring this conserved motif in CRR3 and CRK1are able to bind to the ACR4 kinase domain. Our investigations also indicate that the ACR4 ICD can interact with and phosphorylate the transcription factor WOX5.

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Section: Discussionmentioning

confidence: 99%

Evidence for Intermolecular Interactions between the Intracellular Domains of the Arabidopsis Receptor-Like Kinase ACR4, Its Homologs and the Wox5 Transcription Factor

Meyer

Shah

Zhang³

et al. 2015

PLoS ONE

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Development of prosocial behaviour in children after the improvement of family competences

Socías

Brage

March

et al. 2015

Journal of Children's Services

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Purpose – This research assesses the predictive capacity of key factors in the development of family competences: parent-children relationship, family involvement, family resilience and positive parenting. It also aims to establish which are the most discriminating factors between the groups showing the most and the least prosocial behaviours. Design/methodology/approach – The study involves a longitudinal study of one child from 181 families; 155 families in the experimental group and 26 in the control group. Both boys and girls are included and their ages range from 8 to 14 years. The instruments employed are all validated for use with a Spanish population and include Karol Kumpfer’s questionnaires on family competence and the BASC questionnaire. Findings – All of the factors analysed, with the exception of family involvement, proved to be predictive for prosocial behaviour, and the most discriminating among these were: parent-children relationship, family resilience and positive parenting. Originality/value – One key issue in family prevention programmes is the development of prosocial behaviour. In this sense, the research developed here aims at highlighting protective factors as key to developing a prosocial behaviour.

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Issue Editors’ Notes

Cited by 2 publications

References 5 publications

Evidence for Intermolecular Interactions between the Intracellular Domains of the Arabidopsis Receptor-Like Kinase ACR4, Its Homologs and the Wox5 Transcription Factor

Evidence for Intermolecular Interactions between the Intracellular Domains of the Arabidopsis Receptor-Like Kinase ACR4, Its Homologs and the Wox5 Transcription Factor

Development of prosocial behaviour in children after the improvement of family competences

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