Intra- and postoperative complications in the surgical treatment of nodular and multinodular euthyroid goiter make up from 0.3 to 8.0% of the number of operated patients. Depending on the clinical picture, data of morphological, radiation, laboratory studies, various types of surgical interventions are used. The objective was to analyze the causes and search for ways to prevent and treat the ntraoperative and postoperative complications in the surgical treatment of patients with nodular and multinodular euthyroid goiter. Methods and materials. There was conducted the analysis of the techniques and results of surgical treatment of 303 patients with nodular euthyroid goiter and 377 patients with multinodular euthyroid goiter, divided into two groups: the main group (352 patients) and comparison (328 patients). Results. The immediate and long-term results of the treatment of patients were studied with the detailing of specific and nonspecific complications by groups. Methods for optimizing diagnostic and treatment technologies have been developed, immediate and long-term results of treatment have been evaluated. Conclusion. The use of improved technologies has reduced the number of intraoperative and postoperative complications and improved treatment results.